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The University of Southampton
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Dr Tristan Clark BM, MRCP, DTM&H, MD

Associate Professor, Honorary Consultant in Infectious Diseases

Dr Tristan Clark's photo

Dr Tristan Clark is an Associate Professor and Honorary Consultant in Infectious Diseases and was appointed in 2013. His research background includes pandemic influenza vaccine trials and the assessment of Point-of-Care diagnostics for acute respiratory infection.

Respiratory viruses represent the commonest infections of humans and so the burden of disease in the community and in hospitals is huge. My work aims to improve the diagnosis and care of patients with respiratory virus infection'

Dr Clark qualified as a doctor from Southampton University in 1998 and undertook his early clinical training in Poole, Southampton , Portsmouth and Bristol. He subsequently spent time working abroad, firstly in Sudan running TB and Visceral Leishmaniasis programmes, and then in Darwin, Northern Australia doing clinical infectious diseases. He completed his Specialist registrar training in Infectious diseases and general internal medicine in Leicester where he gained a wealth of experience in the clinical management of TB (including MDRTB), HIV and viral hepatitis.

Whilst training in Leicester Dr Clark developed research interests in Influenza and other respiratory viruses and completed an MD thesis. He ran several pandemic influenza vaccine trials including avian H5 and swine origin H1 influenza. Other themes from his research have included; the utility of rapid diagnostic tests for influenza and pneumococcus, the clinical application of biomarkers (Procalcitonin and CRP) in acute respiratory illness, the burden of respiratory virus infection in hospitalised adults and the molecular epidemiology of human rhinovirus.


BM, University of Southampton (1998)
DTM&H, University of Liverpool (2000)
MRCP, Royal College of Physicians London (2001)
MD, University of Leicester (2013)

Appointments held

House Officer Medicine, Poole general Hospital (1998)
House Officer Surgery , Portsmouth Hospitals (1999)
Senior House Officer A+E, Southampton General Hospital (2000)
Senior House Officer Medical Rotation, Portsmouth Hospitals (2000-2002)
Senior House Officer ITU, Portsmouth Hospitals (2002)
Clinical Fellow Infectious diseases, University of Bristol (2003)
Field Doctor, Medecins Sans Frontieres (MSF), Sudan (2003-4)
Registrar Infectious Diseases and GIM, Darwin Hospital, Australia (2005)
Specialist Registrar Infectious Diseases and GIM, Leicester Royal Infirmary (2006-2011)
Consultant Physician, Royal Cornwall Hospital (2012-13)
Senior Lecturer and Honorary Consultant Infectious diseases, University of Southampton (2013-present)

Research interests

Pandemic Influenza vaccines

Dr Clark was part of a team that evaluated the safety and immunogenicity of pandemic influenza vaccines against swine origin H1N1, the results of which have been published in high impact international journals. He has also evaluated a prime-boost vaccination strategy against avian H5 influenza. Potential ongoing projects include vaccine evaluation against the newly emerging H7N9 influenza virus in China, which has pandemic potential.

Respiratory viruses in hospitalised adults

Dr Clark is currently running clinical trials at UHS examining the use of point-of-care diagnostics for respiratory virus infection in hospitalised adults.
Dr Clark has examined the role of respiratory viruses in adults hospitalised with acute respiratory illness and found a high burden of viruses, particularly Human Rhinovirus. Potential ongoing projects include prospective studies in hospitalised adults using universal screening.

Rapid diagnostic tests and biomarkers

Dr Clark has explored the role of biomarkers such as CRP and Procalcitonin and rapid diagnostic tests for influenza and pneumococcus in improving the clinical management of hospitalised adults with acute respiratory disease. Potential ongoing projects include evaluating the use of novel rapid molecular diagnostic tests for influenza.

Research project(s)

CERAbTc-19 (Clinical Evaluation of Rapid Antibody Test for Covid-19)


Regular peer reviewer for NIHR grant applications and scientific journal including; Clinical Infectious Diseases, Thorax, European Infectious Diseases, Journal of Infection and Vaccine.

Specialist advisor to the National Institute of Health and Care Excellence on neuraminidase inhibitors


Member of Scientific Advisory Committee, British Infection Association


NIHR Clinical Research Network speciality group lead for Infectious Diseases and Microbiology, Wessex

Deputy Training Programme Director, Infectious Diseases and Microbiology, Wessex

Educational supervisor for Specialist registrars in Infectious Diseases and clinical research fellows


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Dr Clark teaches Infectious Disease and Clinical Microbiology to undergraduates and postgraduate clinicians

Dr Tristan Clark
Faculty of Medicine, University of Southampton, Building 85, Life Sciences Building, Highfield Campus, Southampton, SO171BJ

Room Number: SGH/LF101

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