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The University of Southampton
Medicine

Dr Michael Ardern-Jones BSc, MBBS, DPhil, FRCP

Associate Professor of Dermatology, Consultant Dermatologist

Dr Michael Ardern-Jones's photo

Michael Ardern-Jones is a leader in UK dermatology. He is an internationally recognised expert on inflammation in the skin with a particular focus on atopic dermatitis and drug hypersensitivity reactions.

Michael Ardern-Jones is a leader in UK dermatology. He is an internationally recognised expert on inflammation in the skin with a particular focus on atopic dermatitis and drug hypersensitivity reactions.
Michael Ardern-Jones (MAJ) trained in Dermatology at St John’s Institute of Dermatology, London and Churchill Hospital, Oxford. His DPhil (PhD) at Christ Church, Oxford explored the immunology of atopic dermatitis. He was appointed to University Hospitals Southampton NHS Trust and to the Faculty of Medicine, University of Southampton in 2007.

He has a specific academic interest in inflammatory skin disease and leads the clinical service for eczema, and drug hypersensitivity reactions. His clinical unit undertakes clinical trials in atopic eczema and other skin diseases. MAJ has long-standing research interest in all aspects of atopic eczema including immunological mechanisms, immunotherapy, and the skin microbiome. His research lab comprises post-doctoral scientists, PhD students, clinical fellows and technicians.

Michael Ardern-Jones previously served as President of the British Society for Medical Dermatology and Chair of the British Society for Investigative Dermatology. He also chairs The Skin Investigation Society. He is lead author on the Atopic eczema chapters and co-author for Drug allergy in Rook’s Textbook of Dermatology. He is an expert advisor to NICE and the MHRA on dermatology.

 

Qualifications

B.Sc, Biochemistry, University of London, 1993

MB.BS, Medicine and Surgery, University of London, 1996

MRCP, Royal College of Physicians, 1999

DPhil, University of Oxford, 2007

 

Work history

Associate Professor in Dermatology / Honorary Consultant, University of Southampton, 2014 - onwards

Senior Lecturer in Dermatology / Honorary Consultant University of Southampton, 2007-14

Wellcome Trust Research Training Fellow /Senior Clinical RTF, University of Oxford, 2004-07

Specialist Registrar Dermatology, Oxford deanery, 1999-2004

Research interests

  • Cutaneous immunology
  • Atopic dermatitis / Atopic eczema
  • Skin microbiome
  • Skin allergy
  • Drug hypersensitivity
  • Stevens-Johnson syndrome (SJS)
  • Toxic epidermal necrolysis (TEN)
  • Drug reaction with eosinophilia and systemic symptoms (DRESS)

Together with Dr Polak (Post Doctoral Research Scientist), Dr Ardern-Jones has developed a 3D in vitro model of the skin which can be used to further investigate cutaneous immunology without the need for human tissue samples. Skin research has a distinct advantage over other organ systems in that there is good access to skin biopsies if needed. Using the latest immunological tools (Fig1 novel MHC class II tetramers..) Dr Ardern-Jones aims to address key questions in cutaneous immunology. The group has 4 main areas of interest within the field:

1) The role of microbial regulation of immune responses in atopic dermatitis

Infections are well recognised causes of flares in eczema. Using laboratory cultured Staphylococcus aureus, Dr Ardern-Jones is investigating how this bacteria can redirect the cutaneous immune response towards allergic responses.

2) The interaction between cutaneous DCs and adaptive immunity

It has long been established that certain cytokine profiles correspond with allergic reactions, yet why some individuals and not others should programme their immune responses in this way is not well understood. Testing cells outside of the tissue microenvironment fails to reproduce the signals that coordinate an individual immune response. Using 3D models of the skin, Dr Ardern-Jones’ group can test the molecular pathways involved in this immune programming.

3) Development of novel in vitro diagnostic tests for drug hypersensitivity

Allergic reactions to drugs are mediated by immune responses in the blood and frequently manifest as rashes on the skin. Although many are mild, some can be fatal. To date we have no reliable methods of identification of the culprit medication and therefore clinical management of these cases is often based on bets guess and is less than satisfactory. Using his experience in working with immunological tests for other projects, Dr Ardern-Jones’ group is recognised as the leading group in the UK working on assay optimisation for clinical use.

4) Mathematical modelling of the regulation of Th polarisation

Complexity in biological systems has driven a reductionist approach, whereby favourite molecules or pathways are examined in depth. New technologies such as microarray analysis of encoded RNA, allows researchers to study complexity in a non-hypothesis driven way. As part of Dr Ardern-Jones’ group, Dr Polak is using microarray analysis and novel bioinformatics systems to model the whole cellular processing that regulates a dendritic cell to at one time choose to induce immunity and at other times allergy.

 

PhD - 4 Completed; 2 Ongoing; 2 in start up

MD - 2 Ongoing

Using novel NHC class II tetramers to track human T cell immune responses to house dust mite protein
Arden-Jones et al. PNAS USA

Research group

Clinical and Experimental Sciences

Affiliate research group

Respiratory and allergy Research group

2020-   BAD Research Subcommittee Chair

2018-   Wessex CRN Dermatology lead

2018-   MHRA Chair – Paraffin emollient working group

2018-   British Journal of Dermatology Editorial Board

2017-   Chair, Steering committee. UK-Irish Atopic Eczema Systemic Therapy Register (A*STAR)

2017-   NIHR Dissemination Centre panel of expert commentators

2016-20  APRICOT trial data monitoring committee (NIHR)

2016-   TREAT Trial Deputy Chair of Steering Committee (EME-MRC-NIHR)

2015-   Commission on Human Medicines (MHRA) Dermatology Expert Advisor (GRID EAG)

2015-   National Institute of Health and Care Excellence (NICE) Scientific Advisor

2015-   International Eczema Council Regional Councilor

2015-20   University of Oxford – Clinical Immunology MSc External examiner

2014-6 Chairman, British Society for Investigative Dermatology

2014-5 Member, NICE Quality Standard Advisory Committee (QSAC) -drug allergy

2014-   UKTREND (UK Translational Research in Dermatology) Steering Committee

2011-   Chairman, The Skin Investigation Society (THESIS)

2009-   Member, RCP Dermatology Specialty Curriculum Examination Exam Board

2009-16   Member, RCP Dermatology Specialty Curriculum Examination Standard Setting Group

2005-10   Member, RCP Dermatology Specialty Curriculum Examination Question writing Group

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Articles

Book Chapters

  • Ardern-Jones, M., & Friedmann, P. (2009). Eczema. In A. Custovic, & T. A. E. Platt-Mills (Eds.), Managing Allergy Clinical Publishing.
  • Friedmann, P. S., Ardern-Jones, M., & Holden, C. A. (2008). Atopic dermatitis. In T. Burns, S. M. Breathnach, N. H. Cox, & C. Griffiths (Eds.), Rook's Textbook of Dermatology (8th revised edition) John Wiley.

Conference

Letters/Editorials

Review

  • Module leader MSc Allergy: Eczema
  • Module leader MSc Allergy: Drug allergy
  • Medical Student teacher
Dr Michael Ardern-Jones
Dermatology
CES Academic Unit
Level F, South Block MP825
Southampton General Hospital
Tremona Road
Southampton SO16 6YD


Room Number NNN: SGH/LF76/MP825

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