Eugen Stulz is Associate Professor in Bioorganic and Materials Chemistry. His research interests are interdisciplinary, spanning chemistry, biology, medicine and chemical engineering. The main aims are to tackle diseases such as cancer, and addressing environmental issues such as energy conversion.
You can update this in Pure (opens in a new tab). Select ‘Edit profile’. Under the heading and then ‘Curriculum and research description’, select ‘Add profile information’. In the dropdown menu, select - ‘About’.
Write about yourself in the third person. Aim for 100 to 150 words covering the main points about who you are and what you currently do. Clear, simple language is best. You can include specialist or technical terms.
You’ll be able to add details about your research, publications, career and academic history to other sections of your staff profile.
- DNA chemistry
- Chemical Biology
- Medicinal chemistry
- Gene expression
The general research interests in the Stulz group are concerned with supramolecular chemistry, bio-nanotechnology, medicinal chemistry, nanoparticles and microfluidics.
We are mainly exploring the use of modified DNA in a number of applications, ranging from electronics over gene expression to novel platform technologies in health care. The research is highly interdisciplinary, and reaches into materials science, nanotechnology, analytical science, and into biological / medicinal sciences. We have reviewed the progress in the use of modified DNA in Chem. Soc. Rev. 2011, in Chem. Eur. J. 2012 and in Acc Chem Res 2017. We have also contributed to books and book chapters: Bio-inspired Functional DNA Architectures (Springer 2021); DNA in Supramolecular Chemistry and Nanotechnology (Wiley 2014).
In addition, we are investigating in the synthesis of silver nanoprisms for energy applications. We have shown that Ag-NPs can successfully be embedded in a polymer matrix and coated onto glass windows, thus forming an IR-light blocking layer to create more energy efficient windows. One of our main themes is now to develop 3D-printed flow-through reactors for continuous flow synthesis of Ag-NPs, which can also be applied to other nanoparticles (e.g. liposomes). The costs of a device is now as low as £5.
DNA in the chemistry - biology - medicine interface
We use modified nucleotides and oligonucleotides (ONs) in biology and medicine to target a number of issues. In particular gene expression and diagnostics profit highly from the use of synthetic DNA. We are pursuing several systems to address regulation of gene expression, targeted cell killing and sensing of ODN markers; the majority of the applications are targeted at cancer therapy.
To advance the field of ONs in medicinal applications, we are leading the H2020-MSCA-ETN OLIGOMED, which comprises academic groups, SMEs, pharma and hospitals across Europe and targets cancer, Huntington's Disease and cardiovascular diseases.
We have developed DNA based membrane nanopores, which form stable inclusion complexes in lipid bilayers. Together with the groups of Stefan Howorka (UCL) and Ulrich Keyser (Cambridge) we have studied several types of pore forming DNA systems ( HOT paper in Angew. Chem. 2013, Nano Lett. 2013). We found that two porphyrins are sufficient to form very stable insertions for a six-helical DNA bundle. The simple design allows for the creation of a pore of approximately 5 nm width and 14 nm height, with an inner pore diameter of 2 nm. Current recordings of the ionic flow across the lipid bilayer confirms the formation of the nanopore.
In addition, we could show that a 6-porphyrin containing DNA duplex inserts into the lipid bilayer and induces a flow of ions along the phosphate backbone. This leads to the formation of the smallest possible DNA nanopore, i.e. a single DNA duplex (Nano Lett. 2016). It also reveals that it will not be possible to completely suppress ion flows in larger DNA nanopores, e.g. by blocking the channel.
We are now investigating the nanopores in targeted cell killing.
Porphyrins have shown to be perfectly well suited to create electrochemical sensors for DNA. Together with the group of Jerzy Radecki and Hanna Radecka in Olsztyn, Poland, we are using cobalt metallated porphyrins that show to be ultrasensitive towards hybridisation with the complementary sequence (Chem. Commun. 2014). The sensor is very selective, able to discriminate single nucleotide polymorphism, and extremely sensitive: with the use of gold nanoparticles on the surface of the electrode, our sensors have a detection limit in the attomolar range and can sense as few as 23 DNA molecules (Chem. Commun. 2018; Bioelectrochemistry 2021).
Silver Nanoparticles in energy
In times of man-made global warming – and with it climate change – it is crucial to tackle general energy problems. Our efforts to contribute to this field is in the formation of silver nanoprisms and nanorods, which efficiently absorb infrared light. These can be coated in a silica shell and covalently embedded in a PMMA matrix for coating of windows (J. Mater. Chem. C 2016). In this way we have shown that the Ag-NPs are able to block the IR light efficiently with sub-mm film thickness. This is a well-going collaboration with the group of Xunli Zhang in Engineering.
Flow through reactors
Our focus is on designing cheap flow-through reactors for the synthesis of nanoparticles (RSC Adv. 2014; J. Mater. Chem. C 2013), in particular silver nanospheres and nanoprisms, but they are also applicable to the fabrication of liposomes. We design the channels of the flow reactors according to best mixing of the different solutions and create a mould using 3D printing (New Biotechnology 2018). The reactor is then made using PDMS and either covering with a glass slide or adhesive tape. This allows to make a flow reactor in less than a day, at costs of less than £5.
You can update the information for this section in Pure (opens in a new tab).
Any research groups you belong to will automatically appear on your profile. Speak to your line manager if these are incorrect. Please do not raise a ticket in Ask HR.
Add up to 5 research interests. The first 3 will appear in your staff profile next to your name. The full list will appear on your research page. Keep these brief and focus on the keywords people may use when searching for your work. Use a different line for each one.
In Pure (opens in a new tab), select ‘Edit profile’. Under the heading 'Curriculum and research description', select 'Add profile information'. In the dropdown menu, select 'Research interests: use separate lines'.
Update this in Pure (opens in a new tab). Select ‘Edit profile’ and then ‘Curriculum and research description - Current research’.
Describe your current research in 100 to 200 words. Write in the third person. Include broad key terms to help people discover your work, for example, “sustainability” or “fashion textiles”.
Research Council funded projects will automatically appear here. The active project name is taken from the finance system.
Public outputs that list you as an author will appear here, once they’re validated by the ePrints Team. If you’re missing any outputs that you’ve added to Pure, they may be waiting for validation.
Current PhD Students
Contact your Faculty Operating Service team to update PhD students you supervise and any you’ve previously supervised. Making this information available will help potential PhD applicants to find you.
I am currently teaching in the following modules and projects:
- CHEM2028 Reaction Mechanisms in Organic Chemistry (module lead) (Y2S1)
- CHEM2036 Chemical solutions to environmental issues (Y2S2)
- CHEM6145 Supramolecular chemistry of functional molecules and materials (Y4S2)
- Year 3 and Year 4 projects
- MSc projects
You can update your teaching description in Pure (opens in a new tab). Select ‘Edit profile’. Under the heading and then ‘Curriculum and research description’ , select ‘Add profile information’. In the dropdown menu, select – ‘Teaching Interests’. Describe your teaching interests and your current responsibilities. Aim for 200 words maximum.
Courses and modules
Contact the Curriculum and Quality Assurance (CQA) team for your faculty to update this section.
External roles and responsibilities
These are the public-facing activities you’d like people to know about.
This section will only display on your public profile if you’ve added content.
You can update your external roles and responsibilities in Pure (opens in a new tab). Select ‘+ Add content’ and then ‘Activity’, your ‘Personal’ tab and then ‘Activities’. Choose which activities you want to show on your public profile.
You can hide activities from your public profile. Set the visibility as 'Backend' to only show this information within Pure, or 'Confidential' to make it visible only to you.
Dr Eugen Stulz is Associate Professor in Bio-organic and Materials Chemistry with a focus on DNA chemistry and nanomaterials for biological/medicinal and energy applications.
"Always expect the unexpected"
Eugen Stulz graduated from the University of Bern (Switzerland) in 1994, where he subsequently studied for a Ph.D. under the supervision of Prof. Christian J. Leumann. His thesis was concerned with the evaluation of artificial nucleases based on zirconium(iv) complexes. In 1999, he moved to Cambridge (UK), first as a Swiss National Science Foundation (SNF) Postdoctoral fellow, then as an Advanced Research Fellow (SNF), to the group of Prof. Jeremy K. M. Sanders. There he was working in the field of supramolecular chemistry and dynamic combinatorial libraries using phosphine-substituted porphyrins. During this time, he also held a part-time teaching position at Anglia Polytechnic University. In 2003, he moved to the University of Basel (Switzerland) as a Lecturer (Habilitand) with a Treubel Foundation Fellowship and started his independent research in the field of supramolecular chemistry using DNA as scaffold for multiporphyrin arrays. In 2006, he was appointed Lecturer in Chemistry at the University of Southampton, promoted Senior Lecturer in 2010 and Associate Professor in 2014.
His key interests are in the field of DNA technology in its widest sense, spanning from supramolecular chemistry over DNA nanotechnology to medicinal applications in cancer therapy. In addition, he is involved in key research developing silver nanoparticles for energy applications.
Diploma in Chemistry, University of Bern, 1994
PhD in Chemistry, University of Bern, 1998
PDRA, Cambridge University, 1999-2002
Lecturer, Anglia Polytechnic University, 2002
Lecturer, University of Basel, 2003-2006
Lecturer, University of Southampton, 2006-2010
Senior Lecturer, University of Southampton, 2010-2014
Associate Professor, University of Southampton, 2014-date
You can update your biography section in Pure (opens in a new tab). Select your ‘Personal’ tab then ‘Edit profile’. Under the heading, and ‘Curriculum and research description’, select ‘Add profile information’. In the dropdown menu, select - ‘Biography’. Aim for no more than 400 words.
This section will only appear if you enter the information into Pure (opens in a new tab).
You can update this section in Pure (opens in a new tab). Select ‘+Add content’ and then ‘Prize’. using the ‘Prizes’ section.
You can choose to hide prizes from your public profile. Set the visibility as ‘Backend’ to only show this information within Pure, or ‘Confidential’ to make it visible only to you.