Paul Elkington is a clinician scientist with a subspecialty interest in tuberculosis. He delivers inpatient care on the respiratory wards and outpatient tuberculosis care, and has a broad teaching portfolio. Paul leads the tuberculosis research group, studying an infection that continues to kill four thousand people every day. The group conducts cross-disciplinary research using bioengineering approaches to identify new diagnostic and therapeutic strategies to address a global epidemic that is second only to COVID-19, and has killed more humans than any other infection. In addition, Paul initiated and co-directed the Personal Respirator Southampton (PeRSo) project, providing highly efficacious and sustainable PPE during waves 1 and 2 of the COVID-19 pandemic. Paul was awarded an MBE for services to medicine in 2020.
You can update this in Pure (opens in a new tab). Select ‘Edit profile’. Under the heading and then ‘Curriculum and research description’, select ‘Add profile information’. In the dropdown menu, select - ‘About’.
Write about yourself in the third person. Aim for 100 to 150 words covering the main points about who you are and what you currently do. Clear, simple language is best. You can include specialist or technical terms.
You’ll be able to add details about your research, publications, career and academic history to other sections of your staff profile.
- matrix metalloproteinase
The Southampton Tuberculosis research group studies how infection destroys the lungs and how this can lead to new diagnostic tests and treatments to combat the global pandemic. The group is highly interdisciplinary, combining engineering approaches such as bioelectrospray methodology and novel proteomic approaches. Key achievements include: identifying the enzymes that destroy the lungs in human TB; developing a biomimetic 3-dimensional cell culture model of TB; performing the most detailed proteomic profiling study of human plasma in TB and validating entirely novel diagnostic markers; demonstrating the mechanism whereby cancer immunotherapy can re-activate TB infection; identification of new host-directed therapy targets, including progressing to a successful clinical trial of doxycycline to reduce lung damage. Current active funding includes the MRC, Rosetrees Trust, PHE, NIHR and MRF, and the focus of the group centres on basic disease mechanisms and how this informs new control strategies.
You can update the information for this section in Pure (opens in a new tab).
Any research groups you belong to will automatically appear on your profile. Speak to your line manager if these are incorrect. Please do not raise a ticket in Ask HR.
Add up to 5 research interests. The first 3 will appear in your staff profile next to your name. The full list will appear on your research page. Keep these brief and focus on the keywords people may use when searching for your work. Use a different line for each one.
In Pure (opens in a new tab), select ‘Edit profile’. Under the heading 'Curriculum and research description', select 'Add profile information'. In the dropdown menu, select 'Research interests: use separate lines'.
Update this in Pure (opens in a new tab). Select ‘Edit profile’ and then ‘Curriculum and research description - Current research’.
Describe your current research in 100 to 200 words. Write in the third person. Include broad key terms to help people discover your work, for example, “sustainability” or “fashion textiles”.
Research Council funded projects will automatically appear here. The active project name is taken from the finance system.
Public outputs that list you as an author will appear here, once they’re validated by the ePrints Team. If you’re missing any outputs that you’ve added to Pure, they may be waiting for validation.
Current PhD Students
Contact your Faculty Operating Service team to update PhD students you supervise and any you’ve previously supervised. Making this information available will help potential PhD applicants to find you.
Professor Elkington teaches undergraduates, postgraduates, junior doctors and allied health professionals. Examples include:
Lecturing on infection and tuberculosis for BM5 programme
Research and innovation presentations on the PeRSo project
BMedSci and MMedSci student supervision
OSCE and ACC examinations
TB teaching to FY1, FY2, IMT and specialty trainee doctors
You can update your teaching description in Pure (opens in a new tab). Select ‘Edit profile’. Under the heading and then ‘Curriculum and research description’ , select ‘Add profile information’. In the dropdown menu, select – ‘Teaching Interests’. Describe your teaching interests and your current responsibilities. Aim for 200 words maximum.
Courses and modules
Contact the Curriculum and Quality Assurance (CQA) team for your faculty to update this section.
External roles and responsibilities
You can update your external roles and responsibilities in Pure (opens in a new tab). Select ‘+ Add content’ and then ‘Activity’, your ‘Personal’ tab and then ‘Activities’. Choose which activities you want to show on your public profile.
You can hide activities from your public profile. Set the visibility as 'Backend' to only show this information within Pure, or 'Confidential' to make it visible only to you.
Prof Elkington trained in medicine at Oxford and then worked in various London teaching hospitals, in addition to Zambia, and completed his training in respiratory and general medicine in 2007. His research into lung destruction in tuberculosis started in Jon Friedland’s group at Imperial College London with a Wellcome Trust Clinical research training fellowship (2002 – 2005), followed by a NIHR Clinician Scientist Award (2006 – 2011), and then a HEFCE Clinical Senior Lecturer Award (2011 - 2016). He moved to Southampton University in June 2012 to develop a research programme centred on the role of proteases in the pathology of pulmonary infection. With Liku Tezera, he has developed the 3D bioelectrospray model of tuberculosis, which has provided entirely novel insights into disease pathogenesis. Prof Elkington has also co-chaired the Faculty Athena SWAN committee, awarded Silver in 2015 and 2021, is lead for Organisation in the TransFoM programme, and is section head for Innate Immunity. At the start of the COVID-19 pandemic, he initiated and co-directed the PeRSo project, providing over 1,500 respirators to staff at Southampton General Hospital in wave 1, and over 3,500 in wave 2, all requested by staff. Prof Elkington is secretary to the Acid Fast Club, the national tuberculosis research association, and was awarded an MBE for services to Medicine in 2020.
- MBE for services to Medicine (2020)
- Royal Academy of Engineering President's Award (2020)
- Vice-Chancellor's Award (2020)
- Shine a Light Award (2020)
You can update your biography section in Pure (opens in a new tab). Select your ‘Personal’ tab then ‘Edit profile’. Under the heading, and ‘Curriculum and research description’, select ‘Add profile information’. In the dropdown menu, select - ‘Biography’. Aim for no more than 400 words.
This section will only appear if you enter the information into Pure (opens in a new tab).
You can update this section in Pure (opens in a new tab). Select ‘+Add content’ and then ‘Prize’. using the ‘Prizes’ section.
You can choose to hide prizes from your public profile. Set the visibility as ‘Backend’ to only show this information within Pure, or ‘Confidential’ to make it visible only to you.