Research
Research groups
Research interests
- Integrating bioinformatics and advanced cell culture to understand TB immunopathology and find new host-directed therapeutic targets to treat tuberculosis.
Current research
As a translational clinical researcher, I continue to develop my bioinformatic skill set to utilise emerging -omic techniques to understand lung disease and translate to improving patient therapy. I am currently studying clinical samples using spatial and single cell transcriptomics to better understand the immunopathology leading to granulomatous disease.
Publications
Teaching
Cardiopulmonary Depute Module Lead BM5/EU Y1
Respiratory Subject Lead BM5/EU Y1
Lecturing and tutoring on the cardiopulmonary module for BM5/EU Y1 students
Biography
I am an Associate Professor and Consultant in Respiratory medicine, having completed my PhD in 2021, and NIHR Clinical Lectureship in 2022. My PhD allowed me to develop my skills in bioinformatics and advanced cell culture working with M.tuberculosis. The main output from my PhD used unbiased analysis of human samples comparing those infected with tuberculosis to those with sarcoidosis, and identified critical pathways in tuberculosis. In parallel, I trained in 3-dimensional cell culture and performed similar bioinformatic analysis of different culture models of tuberculosis. Integrating both bioinformatic datasets led to investigation of these criticial pathways identified in human samples, using a 3-dimensional cellular model, and finding potentially new host-directed therapeutic targets.
Prizes
- Rosetrees Trust Research Fellowship (2016)
- Scadding-Morriston Davies Joint Fellowship in Respiratory Medicine (2017)
- Keystone Symposia Future of Science Fund Scholarship (2022)
- British Lung Foundation-Asthma UK Early Career Investigator Award (2021)
- American Thoracic Society Science and Innovation Center Award (2020)
- American Thoracic Society Abstract Scholarship (2020)
- Academy of Medical Sciences Starter Grant for Clinical Lecturers (2022)
- Rosetrees Trust continuation award (2022)
- Academy of Medical Sciences SUSTAIN programme (2023)