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Research project

Acellular/Smart Materials - 3D Architecture: UK RMP Hub

Project overview

The UKRMP2 Smart Materials Hub aims to develop the next generation of bioactive scaffolds and biomatrices to treat the eye, the musculoskeletal system and the liver. Regenerative medicine holds the promise of revolutionising patient care addressing the problems of an ageing population.

The Bone and Joint Research Group are part of the Acellular Smart Materials Hub with a specific focus on addressing skeletal repair and function moving from basic discovery science through to clinical translation. Research will seek to address the current unmet need for material systems that not only deliver cells safely but also provide cues for differentiation and the organisation of hierarchical and vascularised tissues. The development of materials with highly controlled spatio-temporal features that can respond to environmental triggers is also key in the quest for smarter more biomimetic solutions. The Acellular Smart materials UKRMP Programme will, over five years deliver innovative acellular material solutions to tissue regeneration with research encompassing fundamental research through to preclinical evaluation and, ultimately clinical delivery.

Staff

Lead researcher

Professor Richard Oreffo

Prof in Musculoskeletal Science

Connect with Richard

Other researchers

Professor Jon Dawson

Prof Fellow of Regenerative Medicine

Connect with Jon

Professor Nick Evans

Professor of Bioengineering

Connect with Nick

Collaborating research institutes, centres and groups

Interdisciplinary Musculoskeletal Health

The University hosts a substantial interdisciplinary community of researchers working to transform musculoskeletal health across the life course.

Research outputs

From hurdle to springboard: the macrophage as target in biomaterial-based bone regeneration strategies
Yanghee Kim,
Richard Oreffo,
& Jonathan Dawson
, 2022 , Bone , 159
DOI: 10.1016/j.bone.2022.116389
Type: article
The role of lithium in the osteogenic bioactivity of clay nanoparticles
Mohamed Mousa,
Juan Aviles Milan,
Oscar Kelly,
Jane Doyle,
Nicholas D Evans,
Richard O C Oreffo,
& Jonathan I Dawson
, 2021 , Biomaterials Science , 9 (8) , 3150--3161
DOI: 10.1039/d0bm01444c
Type: article
De Novo design of functional coassembling organic–inorganic hydrogels for hierarchical mineralization and neovascularization
Richard Oreffo,
Babatunde O. Okesola,
Ana Karen Mendoza-Martinez,
Gianluca Cidonio,
Burak Derkus,
Delali Boccorh,
David Osuna de la Pena,
Sherif Elsharkawy,
Yuanhao Wu,
Jonathan Dawson,
Alastair Wark,
Dafna Knani,
Dave J. Adams,
& Alvaro Mata
, 2021 , ACS Nano , 15 (7) , 11202–11217
DOI: 10.1021/acsnano.0c09814
Type: article
Materials-driven fibronectin assembly on nanoscale topography enhances mesenchymal stem cell adhesion, protecting cells from bacterial virulence factors and preventing biofilm formation
Richard Oreffo,
Laila A. Damiati,
P. Monica Tsimbouri,
Virginia Hernandez,
Vineetha Jayawarna,
Mark Ginty,
Peter Childs,
Y. Xiao,
Karl Burgess,
Julia Anne Wells,
Mark R Sprott,
R. Meek,
Peifeng Li,
Angela Nobbs,
Gordon Ramage,
Bo Su,
Manuel Salmeron-Sanchez,
& Matthew J. Dalby
, 2021 , Biomaterials
DOI: 10.1016/j.biomaterials.2021.121263
Type: article
Structured nanofilms comprising Laponite® and bone extracellular matrix for osteogenic differentiation of skeletal progenitor cells
Richard Oreffo,
Daheui Choi,
Jiwoong Heo,
Juan Aviles Milan,
Jonathan Dawson,
Jinkee Hong,
& Yanghee Kim
, 2021 , Materials Science and Engineering C , 118
DOI: 10.1016/j.msec.2020.111440
Type: article
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