Computational modelling to evaluate, understand and predict the placental transfer of xenobiotics as an integrated system

Staff

Lead researchers

Dr Bram Sengers

Associate Professor

Connect with Bram

Email: B.G.Sengers@soton.ac.uk

Other researchers

Professor Xunli Zhang PhD, DIC, FRSC, CChem, CEng

Professor of Bioengineering

Research interests

Microfluidics and Lab-on-a-Chip Technologies
Biomedical and Chemical Engineering
Nanomaterials

Connect with Xunli

Email: XL.Zhang@soton.ac.uk

Professor Rohan Lewis PhD, FTPS

Prof of Placental&Integrative Physiology

Connect with Rohan

Email: Rohan.Lewis@soton.ac.uk

Dr Jane Cleal PhD

Associate Professor

Research interests

Areas of Scientific Expertise:
Reproductive Cell Biology – Fundamental mechanisms of cell biology in placenta and endometrium and the impact on the intra-uterine environment, fetal development and lifelong health.Regulation of Reproductive Cell Biology – Maternal exposures and molecular regulation of cellular gene expression, phenotype and function in placenta and endometrium and the clinical translation.Disease/phenotype – Fetal growth, Obesity, Cardiometabolic programming, Subfertility, Recurrent pregnancy loss.Cellular mechanisms – Membrane transport, endocytosis, vesicular transport & signalling, gene transcription, microRNA biology, epigenetic regulation.Vitamin D - Transport, regulation, metabolism and signalling.

Connect with Jane

Email: J.K.CLEAL@soton.ac.uk

Research outputs

Computational modelling of paracellular diffusion and OCT3 mediated transport of metformin in the perfused human placenta

Emma M. Lofthouse, Jane Cleal, Rohan M. Lewis & Bram G. Sengers, 2023, Journal of Pharmaceutical Sciences, 112(9), 2570-2580

DOI: 10.1016/j.xphs.2023.05.008

Type: article

3D Visualisation of trans-syncytial nanopores provides a pathway for paracellular diffusion across the human placental syncytiotrophoblast

Rohan Lewis, Harikesan Baskaran, Jools Green, Stanimir A. Tashev, Eleni Palaiologou, Emma Lofthouse, Jane Cleal, Anthony Page, David Chatelet, Patricia Goggin & Bram Sengers, 2022, iScience, 25(12)

DOI: 10.1101/2022.01.26.477815

Type: article

Modelling of 3D placental cell features using deep learning

Benjamin Mills, James Grant-Jacob, Benita, Scout MacKay, Rohan Lewis & Bram Sengers, 2022

Type: conference

Endocytosis in the placenta

Laura D F Cooke, David A Tumbarello, Nicholas C Harvey, Jaswinder K Sethi, Rohan M Lewis & Jane K Cleal, 2021, Placenta, 113, 67-73

DOI: 10.1016/j.placenta.2021.04.014

Type: review

Glibenclamide transfer across the perfused human placenta is determined by albumin binding not transporter activity

Emma Lofthouse, Jane Cleal, Georgina J Hudson, Rohan Lewis & Bram Sengers, 2020, European Journal of Pharmaceutical Sciences, 152

DOI: 10.1016/j.ejps.2020.105436

Type: article

Placental perfusion and mathematical modelling

Rohan Lewis, Jane Cleal & Bram Sengers, 2020, Placenta, 93, 43-48

DOI: 10.1016/j.placenta.2020.02.015

Type: review

Ursodeoxycholic acid inhibits uptake and vasoconstrictor effects of taurocholate in human placenta

Emma M Lofthouse, Christopher Torrens, Antigoni Manousopoulou, Monica Nahar, Jane K. Cleal, Ita M O'Kelly, Bram G. Sengers, Spiros D. Garbis & Rohan M Lewis, 2019, The FASEB Journal, 33(7), 8211-8220

DOI: 10.1096/fj.201900015RR

Type: article