Research project

Immunotherapy for Head and Neck Cancer

Research groups:

Cancer Sciences

Lead researcher:

Professor Gareth Thomas

Research funder:

Medical Research Council

Status:

Not active

Staff

Lead researcher

Professor Gareth Thomas

Professor of Experimental Pathology

Research interests

Fibroblast biology and immunology
Tumour microenvironment
Cancer Immunotherapy

Connect with Gareth

Email: g.thomas@soton.ac.uk

Collaborating research institutes, centres and groups

Cancer Sciences

Our research works towards improving treatment for patients with cancer.

Research outputs

NOX4 inhibition potentiates immunotherapy by overcoming cancer-associated fibroblast-mediated CD8 T-cell exclusion from tumors

K. Ford,

C.J. Hanley,

M. Mellone,

C. Szyndralewiez,

F. Heitz,

P. Wiesel,

O. Wood,

M. Machado,

M.-A. Lopez,

A.-P. Ganesan,

C. Wang,

A. Chakravarthy,

T.R. Fenton,

E.V. King,

P. Vijayanand,

C.H. Ottensmeier,

A. Al-Shamkhani,

N. Savelyeva,

& G.J. Thomas

, 2020 , Cancer Research , 80 (9) , 1846--1860

DOI: 10.1158/0008-5472.CAN-19-3158

Type: article

Targeting head and neck cancer by vaccination

Chuan Wang,

James Dickie,

Ruhcha Sutavani,

Catherine Pointer,

Gareth Thomas,

& Natalia Savelyeva

, 2018 , Frontiers in Immunology , 1--12

DOI: 10.3389/fimmu.2018.00830

Type: article

Pan-cancer deconvolution of tumour composition using DNA methylation

Ankur Chakravarthy,

Andrew Furness,

Kroopa Joshi,

Ehsan Ghorani,

Kirsty Ford,

Matthew J. Ward,

Emma V. King,

Matt Lechner,

Teresa Marafioti,

Sergio A. Quezada,

Gareth J Thomas,

Andrew Feber,

& Tim Fenton

, 2018 , Nature Communications , 9

DOI: 10.1038/s41467-018-05570-1

Type: article