Project overview
We have developed metric linkage disequilibrium maps which have additive distances analogous to linkage maps. Using data both publicly available and in collaborative projects we will apply and extend these methods to develop and integrate standard maps and scaling factors to represent LD in a range of human populations. Construction of maps for whole chromosomes requires GRID technology, database and web development and other bioinformatics applications. Analysis of the maps combines statistical and mathematical genetics and will enable the study of evolutionary aspects of human origins, recombination hot spots and their relationship to sequence and haplotype extension associated with selective sweeps and re-arrangements.
Research outputs
Jane Gibson, William Tapper, Sarah Ennis & Andrew Collins,
2013, Human Genetics, 132(2), 233-243
Type: article
Andrew Collins,
2009, Molecular Biotechnology, 41(1), 83-89
Type: article
Eveliina Jakkula, Karola Rehnstrom, Teppo Varilo, Olli P.H. Pietiläinen, Tiina Paunio, Nancy L. Pedersen, Ulf deFaire, Marjo-Riitta Järvelin, Juha Saharinen, Nelson Freimer, Samuli Ripatti, Shaun Purcell, Andrew Collins, Mark J. Daly, Aarno Palotie & Leena Peltonen,
2008, American Journal of Human Genetics, 83(6), 787-794
Type: article
William Tapper, Jane Gibson, Newton E. Morton & Andrew Collins,
2008, Human Heredity, 66(3), 157-169
DOI: 10.1159/000126050
Type: article
Mehar S. Khatkar, Mehar S. Nicholas, Andrew R. Collins, Kyall R. Zenger, Julie A.L. Cavanagh, Wes Barris, Robert D. Schnabel, Jeremy F. Taylor & Herman W. Raadsma,
2008, BMC Genomics, 9(187)
Type: article
Andrew Collins & Winston Lau,
2008, Journal of Human Genetics, 53(2), 121-126
Type: article
Sarah Ennis, Srini Goverdhan, Angela Cree, Josephine Hoh, Andrew Collins & Andrew Lotery,
2007, British Journal of Ophthalmology, 91(7), 966-970
Type: article