Project overview
We have developed metric linkage disequilibrium maps which have additive distances analogous to linkage maps. Using data both publicly available and in collaborative projects we will apply and extend these methods to develop and integrate standard maps and scaling factors to represent LD in a range of human populations. Construction of maps for whole chromosomes requires GRID technology, database and web development and other bioinformatics applications. Analysis of the maps combines statistical and mathematical genetics and will enable the study of evolutionary aspects of human origins, recombination hot spots and their relationship to sequence and haplotype extension associated with selective sweeps and re-arrangements.
Research outputs
N. Maniatis, N.E. Morton, J. Gibson, C.-F. Xu, L.K. Hosking & A. Collins,
2005, Human Molecular Genetics, 14(1), 145-153
DOI: 10.1093/hmg/ddi019
Type: article
Weihua Zhang, Andrew Collins, Jane Gibson, William J. Tapper, Sarah Hunt, Panos Deloukas, David R. Bentley & Newton E. Morton,
2004, Proceedings of the National Academy of Sciences of the United States of America, 101(52), 18075-18080
Type: article
C.L. Simpson, V.K. Hansen, P.C. Sham, A. Collins, J.F. Powell & A. Al-Chalabi,
2004, Biotechniques, 37(6), 996-999
Type: article
Andrew Collins, Winston Lau & Francisco De La Vega,
2004, Human Heredity, 58(1), 2-9
DOI: 10.1159/000081451
Type: article
Xiayi Ke, Sarah Hunt, William Tapper, Robert Lawrence, George Stavrides, Jilur Ghori, Pamela Whittaker, Andrew Collins, Andrew P. Morris, David Bentley, Lon R. Cardon & Panos Deloukas,
2004, Human Molecular Genetics, 13(6), 577-588
DOI: 10.1093/hmg/ddh060
Type: article