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Southampton Health Technology Assessments CentreNews

New report on the cost-effectiveness of tests for latent TB infection in predicting active tuberculosis

Published: 6 December 2018
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Report on the cost-effectiveness of tests for latent TB infection in predicting active tuberculosis

A prospective cohort study and economic analysis to assess the prognostic value and cost-effectiveness of the two currently used interferon gamma release assays (IGRAs) compared with the standard tuberculin skin test (TST) for predicting active TB among untreated individuals at increased risk of TB: (1) contacts of active TB cases and (2) new entrants to the UK from high-TB-burden countries.

The report ‘Two interferon gamma release assays for predicting active tuberculosis: the UK PREDICT TB prognostic test study’ is freely available from the NIHR Journals Library. This study investigated the optimal screening strategy for LTBI, based on existing technologies. Screening strategies included single tests and sequential combination of tests. The report shows small differences in cost and QALY between the LTBI testing strategies, with no evidence that any particular test or combination of tests was superior to other approaches in identifying individuals who would go on to develop active TB.

SHTAC researchers Professor Joanne Lord and Olu Onyimadu led the health economic analysis for the report.

For more information about SHTAC's research please visit our Research page.

 

 

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