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The University of Southampton
Biological Sciences
Phone:
(023) 8059 4416
Email:
Marcin.Przewloka@soton.ac.uk

Dr Marcin R Przewloka 

Lecturer in Systems Biology, Principal Investigator (Chromosome Biology)

Dr Marcin R Przewloka's photo

Dr Marcin Przewloka is a Lecturer in Systems Biology within Biological Sciences at the University of Southampton. His research interests include chromosome biology, centromeres and kinetochores, cell division, involvement of post-translational modifications of proteins in the regulation of the cell cycle and multi-protein complex formation.

 

 

 

Career History
2016-present: Lecturer in Systems Biology. University of Southampton, UK.
2005-2016: Research Associate. Department of Genetics, University of Cambridge, Cambridge, UK.
2003-2005: Research Associate. Department of Cell Biology, Albert Einstein College of Medicine, New York, USA.
2000-2003: Postdoctoral Research Associate. Bioscience Division, Los Alamos National Laboratory, New Mexico, USA.

Academic Qualifications
2000: PhD. Department of Biology, University of Warsaw, Poland.
1995: MSc. Department of Biology, University of Warsaw, Poland.

Research interests

Faithful transmission of the genetic material to daughter cells is key to maintain genomic integrity at a cellular and organismal level. For this to happen proper chromosome condensation and segregation must occur in a controlled and coordinated manner. Chromosome segregation errors may potentially lead to inheritable abnormalities with severe consequences. Also, aneuploidy and chromosome instability, which arise from chromosomal aberrations, are hallmarks of cancer cells. It is therefore very important to understand mechanisms governing formation of chromosomes and their accurate segregation during cell division

 

Drosophila melanogaster S2 cultured cell imaged during mitosis. Microtubules of the mitotic spindle, red, emanate from white-labelled centrosomes. They are attached to chromosomes (DNA), blue, at kinetochores depicted in green. Two cartoons in the middle illustrate how kinetochores pull chromosomes towards the centrosomes, where future daughter cells will be formed. Yellow arrows show the progression of the mitotic division from metaphase to anaphase to telophase.

Properly functioning kinetochores, very large multiprotein complexes formed on mitotic centromeres, are a prerequisite for correct chromosome segregation. They constitute a dynamic but in the same time very robust connection between chromosomes and microtubules of the mitotic spindle. I study kinetochores’ composition and the regulation of their assembly in early mitosis. I am interested in how protein interaction networks respond to a constantly changing environment at the chromosome-microtubule interface. Also, my studies address a general question of how kinetochore signalling is embedded in and connected to other pathways regulating cell division and more broadly, cell physiology. To gain insight into these fundamental processes I employ integrated multi-disciplinary approach, which uses biochemistry, structural biology, cell biology and proteomics methodologies. I hope that this multi-angle, systemic and collaborative strategy is going to give a deeper and more complete understanding of the kinetochore function in health and disease.

 

Research group

Molecular and Cellular Biosciences

Affiliate research groups

Computational and Systems Biology, Institute for Life Sciences

Research project(s)

Mechanistic insight into the regulatory role of the key kinetochore protein Spc105/KNL1 in chromosome segregation

A large and mostly unstructured protein Spc105/KNL1 is an essential element of the eukaryotic kinetochore. The project addresses a question of how this protein performs its function as a binding platform for multiple regulatory components to control the proper chromosome segregation during mitosis.

Investigating novel mechanisms bridging cell polarity, spindle orientation and chromosome dynamics in mitotic mammary epithelial cells

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Articles

Book Chapters

Module Coordinator

BIOL3001 Current Topics in Cell Biology
BIOL6021 Current Topics in Cell Biology

Lecturer

BIOL1005 Cell biology & genetics
BIOL1006 Cell biology & genetics
BIOL3064 Cancer & Chromosome Biology
BIOL6071 Cancer & chromosome biology
BIOL3001 Current Topics in Cell Biology
BIOL6021 Current Topics in Cell Biology

Project Supervisor

BIOL3034 Laboratory research project
BIOL6011 Library-based literature project
BIOL6013 Advanced laboratory Project

Tutor

BIOL1020 Core Skills in the Life Sciences
BIOL2010 Flow of genetic information
BIOL3059 Bioscience education

 

Dr Marcin R Przewloka
School of Biological Sciences
Faculty of Environmental and Life Sciences
Life Sciences Building 85
University of Southampton
Highfield Campus
Southampton
SO17 1BJ

Room Number: 85/4045

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