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The University of Southampton
MagRes@Soton

Biological NMR Laboratory

Researchers working in the bioNMR laboratory
Researchers working in the bioNMR laboratory

Varian Inova 600MHz Solution NMR System with cryogenically cooled probe

Configured with a 5mm 1H, 13C, 15N inverse detection probe with the electronics cooled to 20K to enhance signal to noise, this system is aimed at biomolecular NMR with the emphasis on protein structure, protein/ligand interactions, affinity measurements, protein dynamics as well as qualitative/quantitative metabolite analysis. Exploring the molecular world using NMR has many possibilities so please see the NMR entry in the Techniques section which also details what you need to think about in terms of sample preparation and amount.

Refilling of Liquid N2
Refilling of Liquid N2

Varian NMR System 600MHz Dual Solids/Solution NMR System

This system features three room temperature solution probes; a standard 5mm HCN triple resonance, a 5mm pentaprobe covering HCNPD and an 8mm HCN probe tunable to 19F.

The 3.2mm and 1.6mm solid state probes can spin samples at up to 20kHz and 40kHz respectively and be equipped with low-gamma accesssories extending the range of nuclei available for study. This system is routinely used to investigate protein/membrane interactions and effects, protein structure in microcrystalline and fibrillar form and new NMR methodologies to extract novel information about biomolecular form and function. Exploring the molecular world using NMR in the solid state has many possibilities so please see the NMR entry in the Techniques section which also details what you need to think about in terms of sample preparation and amount.

Preparation of solid-state samples
Preparation of solid-state samples

Chemagnetics 400MHz Wide Bore Solids NMR System

The 400MHz system is equipped with high power amplifiers and is routinely used to investigate the behaviour of lipids in membranes in the presence of peptides and proteins as well as the states of catalysts in material science.

A range of probes are available including 3.2mm, 4mm and 6mm magic-angle spinning probes and a 5mm single resonance static probe which are tuneable to a broad range of nuclei. Experiments can be conducted at a range of temperature from –100C to 120C.

Exploring the molecular world using NMR has many possibilities so please see the NMR entry in the Techniques section which also details what you need to think about in terms of sample preparation and amount.

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