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The University of Southampton
Medicine
Phone:
(023) 8120 6663
Email:
C.E.Jones@soton.ac.uk

Dr Christine E. Jones BMedSci, BMBS, PgCertHBE, MRCPCH, FHEA, PhD

Associate Professor in Paediatric Infectious Diseases and Immunology , Honorary Consultant in Paediatric Infectious Diseases and Immunology

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Dr Chrissie Jones is an Associate Professor in Paediatric Infectious Diseases and Immunology at the University of Southampton within the Faculty of Medicine.

Infants are at higher risk of infection than any other life stage. My research focuses on interventions in pregnancy and early life to protect infants from infection.

Chrissie Jones qualified from the University of Nottingham and undertook paediatric training, subspecialising in Paediatric Infectious Diseases, in London. Her PhD from Imperial College London took her to Cape Town, South Africa to investigate the effect of maternal HIV infection on the infant’s response to vaccination. She held a Clinical Lectureship at St George’s, University of London where she developed her interest in vaccines in pregnancy in order to protect infants from infection right from birth, motivated by the susceptibility to infection she observed amongst young infants in South Africa. During her clinical training in London, she developed an interest in congenital CMV infection and one strand of her research aims to develop an educational intervention in pregnancy to reduce the risk of women acquiring infection and so preventing infants from developing congenital CMV infection.

She is an investigator for collaborative clinical trials in paediatric infectious diseases, conducting paediatric and pregnancy vaccine trials as part of the UK academic paediatric vaccine group.

Chrissie is the co-director of an international MRC-funded network, the Immunising Pregnant Women and Infants Network. She sits on the executive committee of the Global Alignment of Immunisation Safety Assessment in pregnancy (GAIA), a Bill and Melinda Gates Foundation (BMGF) funded consortium, a leader in the field of safety assessment of vaccines in pregnancy.

She is the medical advisor to the charity CMV Action and the Chair of the European Society of Paediatric Infectious Diseases (ESPID) Committee for Education, actively supporting and developing educational initiatives across Europe.

Qualifications

BMedSci, Medical Sciences, University of Nottingham, 1999
BMBS, Medicine and Surgery, University of Nottingham, 2001
Membership of Royal College of Paediatrics & Child Health, 2004
PhD, Imperial College, London, 2013
PgcertHBE, Healthcare and Biomedical Education, St George’s, University of London, 2015
Fellow of Higher Education Academy, 2015

Appointments held

Associate Professor and Honorary Consultant in Paediatric Infectious Diseases and Immunology, University of Southampton, 2016 -  present

Honorary Senior Lecturer and Honorary Consultant in Paediatric Infectious Diseases, Paediatric Infectious Diseases Research Group, St George's University of London, 2016 - present

Clinical Lecturer in Child Health, St George’s, University of London & Honorary Paediatric Specialist Registrar, St George’s Hospital (2012-2016)

Clinical Research Fellow, Imperial College London, UK (2008-2012)

Honorary Research Associate, University of Cape Town, South Africa (2008-2012)

Paediatric Specialist Registrar: London Deanery (2005 – 2016)

Paediatric Senior House Officer, London Deanery (2002-2005)

Pre-registration House Officer, Queens Medical Centre, Nottingham, UK (2001-2002)     

Research interests

Vaccines in pregnancy

Dr Jones was part of a team that evaluated the effects of pertussis vaccine in pregnancy on the infants response to vaccines, at its introduction in 2012. She continued as an investigator on a subsequent randomised controlled trial of two pertussis vaccines in pregnancy. She is the Prinicipal investigator in a clinical trial of an investigational respiratory syncytial virus (RSV) vaccine in pregnancy. She was a founding member and executive committee member of the GAIA consortium, which has provided key guidance on the evaluation of vaccines in pregnancy for the safety of both mother and child. She was the first author of these widely used guidelines which have been presented at the World Health Organisation.

Dr Jones is the co-director for the IMmunising Pregnant women and INfants neTwork (IMPRINT), a MRC-funded global network and she lead a work strand investigating the mechanisms of transplacental transfer of antibody from mother to child.

Congenital CMV infection

Dr Jones is the Chief Investigator of a National Institute for Health Research (NIHR) funded study (RACE-FIT), which is developing and testing an educational intervention with a randomised controlled trial in pregnancy to reduce the risk of acquisition of CMV infection in pregnancy. This study builds on collaborations with other experts in congenital CMV and also with psychologists with specific expertise in behavioural change.

She is an investigator the Collaborative Anti-viral Study Group (CASG) Toddler Valganciclovir study, which is testing the treatment of older infants and children with congenital CMV.

As a clinician, she is the clinical lead for congenital infections for the region of Wessex and a medical advisor to the charity CMV Action.

Vaccine clinical trials

Dr Jones is currently running clinical trials of vaccines in pregnancy, premature infants and children. She is the Principal Investigator for clinical trial of an investigational respiratory syncytial virus (RSV) vaccine in pregnancy, which aims to prevent severe chest infections in infants. Premature infants may have sub-optimal responses to vaccines, in the BEAR MenB study, the routine vaccine schedule is compared to routine care with an additional dose of the Meningococcal B vaccine.

Key collaborations

Dr Tushna Vandrevala, Professor Paul Heath, Professor Paul Griffiths, Dr Caroline Trotter, Ms Asma Khalil, Dr Anna Calvert, Professsor Beate Kampmann

CMV Action, UK paediatric vaccine group

Dr Jones is interested in supervising students in any of the above areas.

Department(s)

Clinical and Experimental Sciences

Postgraduate student supervision

Current

Dr Anna Calvert: PhD (University of London)
Egle Butkeviciute: PhD (LSHTM)

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Articles

Dr Jones teaches Paediatric Infectious Diseases to undergraduates and postgraduate clinicians

She provides BMedSci student supervision

Chair of the European Society of Paediatric Infectious Diseases (ESPID) Committee for Education, actively supporting and developing educational initiatives across Europe.

I am currently the co-supervisor for two PhD students

Dr Christine E. Jones
Clinical and Experimental Sciences
Room LF102, F Level, South Academic Block
University Hospital Southampton NHS Foundation Trust
Tremona Road, Southampton, SO16 6YD

Room Number: SGH/LF102/MP810

Telephone:(023) 8120 6663
Email:C.E.Jones@soton.ac.uk

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