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The University of Southampton
Medicine

Dr Rahul S Tare MSc, PhD

Lecturer - Musculoskeletal Science and Bioengineering

Dr Rahul S Tare's photo

Dr Rahul Tare is Lecturer in Musculoskeletal Science and Bioengineering within the Faculty of Medicine at the University of Southampton.

My research employs a multidisciplinary approach to bioengineer 3D cartilage tissue from human stem cells for the repair of articular cartilage defects, and seeks to gain insight into the pathogenesis of skeletal diseases through improved appreciation of the molecular regulation of skeletal development

Rahul’s research interests include human stem cells, tissue engineering and skeletal development.

Rahul’s interdisciplinary research harnesses human stem cells, human skeletal cells, tissue engineering strategies, acoustofluidics and computational modelling to generate 3D cartilage tissue grafts for the regeneration of articular cartilage defects, and seeks to gain insight into the pathogenesis of skeletal diseases such as osteoporosis and osteoarthritis through improved appreciation of the molecular regulation of skeletal development.

Potential students and researchers interested in the above- mentioned areas of research are encouraged to contact Rahul.

Rahul’s research employs a multidisciplinary strategy to bioengineer 3D human cartilage tissue grafts for the repair of articular cartilage defects and seeks to gain insight into the pathogenesis of skeletal diseases through improved appreciation of the molecular regulation of skeletal development. The cartilage tissue engineering work has been widely covered by the BBC, New Scientist and BECTИ.RU (a Russian news outlet).

Research highlights include,

1. Demonstration of the first successful application of acoustofluidic bioreactors to bioengineer scaffold-free 3D cartilage constructs from human articular chondrocytes that have the potential for use in restorative surgical techniques for the treatment of focal articular cartilage defects [Lab on a Chip, 2014; 14: 4475-85 – paper included in the top 30 most downloaded articles published in Lab on a Chip in 2014; Lab on a Chip, 2018; 18: 473-85].

2. Elucidation of the key role of 'threshold' oxygen tension in influencing the composition of the extracellular matrix synthesised by human articular chondrocytes in a 3D scaffold-free culture model, thereby providing valuable insight into scaffold-free cartilage bioengineering approaches and their optimisation [Biotechnology and Bioengineering, 2014; 111: 1876-85]

3. Demonstration of the sub-optimal cartilage-forming potential of human bone marrow-derived Skeletal Stem Cells (SSCs), in comparison to human articular chondrocytes, and the propensity of SSC-derived chondrocytes for hypertrophic differentiation, thereby highlighting the crucial role of strategies to augment SSC chondrogenesis and prevent the phenotypic drift to hypertrophy in delivering improved SSC-based cartilage regeneration therapies [Journal of Biomaterials Applications, 2015; 29: 824-36].

4. Elucidation of the significance of BAG-1-mediated protein-protein interactions, specifically BAG-1-mediated activation of estrogen receptor by HSC70, in the regulation of osteoblast development and bone formation [Scientific Reports 2016; 6: 33504].

The research is funded by grants from the European Calcified Tissue Society, Wessex Medical Research, Rosetrees Trust, Research Grants Council of Hong Kong, Versus Arthritis, EPSRC, MRC, Institute for Life Sciences (University of Southampton).

Qualifications

PhD, University of Southampton, UK (2002)
Postgraduate Certificate in Academic Practice, University of Southampton, UK (2013)

Appointments held

Lecturer, Faculty of Medicine, University of Southampton (May 2010 onwards)

Senior Postdoctoral Career Track Fellow, Bone and Joint Research Group, University of Southampton (Jan 2009 – Apr 2010)

Postdoctoral Career Track Fellow, Bone and Joint Research Group, University of Southampton (July 2008 – Dec 2008)

Postdoctoral Research Fellow, Bone and Joint Research Group, University of Southampton (Mar 2004 – June 2008)

Postdoctoral Research Fellow, Department of Cell Biology, University of Massachusetts Medical School, Worcester, USA (Oct 2002 – Feb 2004)

Research interests

Rahul’s research interests include human stem cells, tissue engineering and skeletal development.

Recent research projects include,

1. Stem cell populations from human osteoarthritic cartilage: isolation, characterisation and application in articular cartilage regeneration strategies [Collaborators: Prof Richard Oreffo – University of Southampton; Prof Andrew Zannettino – University of Adelaide]

2. Generating cartilage from human pluripotent stem cells [Collaborator: Dr Franchesca Houghton – University of Southampton]

3. Development of an acoustofluidic bioreactor platform for cartilage tissue engineering [Collaborators: Prof Martyn Hill, Dr Peter Glynne-Jones – University  of Southampton]

4. Analysis of the effects of deletion of the Bag-1 (Bcl-2-associated athanogene-1) gene on skeletal development [Collaborators: Prof Richard Oreffo, Prof Graham Packham, Mr Ramsey Cutress – University of Southampton; Prof Paul Townsend – University of Manchester; Prof Kenneth Ka Ho Lee – Chinese University of Hong Kong]

Affiliated Research Group

Centre for Human Development, Stem Cells and Regeneration

External Primary Research Group

Bioengineering Science Research Group

Research group

Human Development and Health

Affiliate research group

Human Development and Physiology

Current PhD students

Howard Tribe (Primary supervisor)
Alia Hafiz
Juan Aviles Milan

Past PhD students

Lauren Griffith, PhD (Primary supervisor)
Umesh Jonnalagadda, PhD (Primary supervisor)
Joanna Greenhough, PhD (Primary supervisor)
Siwei Li, PhD (Primary supervisor)
Sussane Renz, PhD
Michael Glinka, PhD
Catarina Moura, PhD
Daniel Tang, PhD
Shona Waddell, PhD
Elizabeth Lemm, PhD
Agnieszka Janeczek, PhD
Sam Dias, PhD

Mphil/PhD Research

Funding Agencies

1. European Calcified Tissue Society
2. Wessex Medical Research
3. Rosetrees Trust
4. Research Grants Council of Hong Kong
5. Versus Arthritis
6. EPSRC
7. MRC
8. Institute for Life Sciences, University of Southampton

Responsibilities

1. Member of Programme Group Committees and Exam Boards for the MRes in Stem Cells, Development and Regenerative Medicine, and MSc Diabetes Best Practice programmes 

2. Personal tutor for BM and PG students

3. Head of Field for the Bone and Joint theme – BM5 Research Project module

4. Member of HDH Academic Unit Operations Group

5. Organiser – Open Day for MRes (Stem Cells) programme

6. Member of University Senate (2013-16)

7. Organiser – Bioengineering PGR seminar series (2015-18)

8. Manuscript reviewer for peer-reviewed journals – Apoptosis, Journal of Tissue Engineering and Regenerative Medicine, Experimental Cell Research, Tissue Engineering, Stem Cell Research, Journal of Functional Biomaterials, Connective Tissue Research, Journal of Tissue Engineering, Scientific Reports, Biomaterials, PLoS One

9. Grant reviewer for BBSRC, MRC, Arthritis Research UK, Swiss National Science Foundation, Orthopaedic Research UK, Action Research UK, Croucher Foundation (Hong Kong), Lower Austrian Company for Research and Education (NFB)

10. External PhD examiner

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Patents

1. Bachelor of Medicine, Bachelor of Surgery BM5 programme

a. Locomotor module (MEDI1033): Lectures -    Bone physiology
b. Formulate multiple choice questions
c. Research for Medicine and Health module (MEDI2045): Project group representative at the poster sessions for presentation of Bone and Joint research projects to Yr. II students
d. Research Project module (MEDI3048): Organise allocation of students to research projects; supervision of project students; mark project reports and oral presentations
e. MMedSc Research Project module (MEDI6220): Supervision of project students; mark project reports

2. Bachelor of Medicine, Bachelor of Surgery BM4 programme

a. Foundations of Medicine module (MEDI3039): Lecture - Calcium homeostasis
b. Formulate multiple choice questions
c. Facilitation

3. Faculty of Medicine Postgraduate Student Training programme

a. Lecture - Role of epigenetics in the regulation of gene transcription
b. Lecture - PCR and Real-time qPCR 

4. MRes in Stem Cells, Development and Regenerative Medicine

a. Deputy Programme Director: Supporting the Programme Director in the design and delivery of the various modules, in addition to administrative roles associated with the programme e.g. timetabling; preparation of module and programme reports; updating module and programme specifications; participation in student fora meetings, programme group meetings, examination boards, scrutiny panel meetings; organisation of Open Days; marketing of the programme; active involvement in all aspects of the student selection process (e.g. shortlisting candidates, arranging and conducting interviews, completing post-interview paperwork)
b. Module Lead: Advanced Scientific Skills (MEDI6224)
c. Module Lead: Research Project 1 (MEDI6225)
d. Deputy Module Lead: Stem Cells, Development and Regenerative Medicine (MEDI6223)
e. Deputy Module Lead: Research project 2 (MEDI6222)
f. Present and organise lectures, journal clubs and workshops; supervision of project students; marking and moderation

5. MSc Diabetes Best Practice

a. Foundations of Diabetes module (MEDI6107): Lecture - Reflective Practice
b. Mark oral presentations and reflective accounts

6. MSc Biomedical Engineering

a. Human Biology and Systems Physiology module (MEDI6226): Lecture – Stem Cells
b. Supervision of project students; mark project reports and poster presentations

7. Bachelor/Master of Engineering (Mechanical Engineering)

a. Biomaterials module (SESM3028): Lecture – Biomaterials in Regenerative Medicine
b. Supervision of project students; mark project reports and poster presentations

Dr Rahul S Tare
Centre for Human Development, Stem Cells and Regeneration
Institute of Developmental Sciences
Room: DS D09, Mailpoint: 887
University Hospital Southampton
Tremona Road
Southampton SO16 6YD
United Kingdom
Telephone: +44 (0)23 8120 5257
Email: R.Tare@soton.ac.uk

Room Number: SGH/DS D09/MP887

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