About
I am a clinical academic neurologist with a subspecialist interest in multiple sclerosis. My clinical practice is based at Hampshire Hospitals NHS Foundation Trust.
My research interests include:
- The impact of systemic infection on the brain, in particular how this affects people with neurological diseases. Systemic infections are the most common cause of hospital admission for people with neurological disease and are associated with poor outcomes. I am the Chief Investigator of the MRC-funded SIBIMS study which is looking at multiple sclerosis in particular.
- Blood-brain barrier (BBB) health, and its measurement for research and clinical use with dynamic contrast-enhanced MRI, which I set up in Southampton. BBB disruption may explain how systemic infection and inflammation affects brain function. This technique can also help guide treatments for multiple sclerosis and I am exploring this in the EQUANIMS study, in collaboration with the Institute for Medical Imaging and Visualisation at Bournemouth University. In the PEBBAL study we are investigating use in Alzheimer's disease (funded by the Alzheimer's Society) . In the SUNLIGHT study we are examining the association between vascular injury and long-term outcome after traumatic brain injury (funded by Ferblanc and the RFU Injured Players Fund, and in collaboration with the TBI-REPORTER network).
- Regional differences in cerebral blood vessels, and how this impacts differential susceptibility to disease. I have an interdisciplinary collaboration with Professor Zudi Lu (City University of Hong Kong) and Dr Chao Zheng to investigate this using spatial statistics.
- Using clinical imaging data for research, funded by and using the infrastructure of the Wessex Secure Data Environment and Southampton Biomedical Research Centre.
- Neurological complications of COVID-19. I co-founded the CoroNerve Studies Group which led the first nationwide surveillance programme for neurological complications of COVID-19. I provide medical advice to Headway about brain injury related to Covid.
- Clinical trials in multiple sclerosis, and I am currently involved in Southampton's recruitment for OCTOPUS, a major new treatment trial for people with progressive MS. I am also the PI for the MS Register in Hampshire Hospitals.
I am also interested in how medicine, particularly neurology, is represented in literature. I have written on the works of Graham Greene, and Ian Fleming, and appeared on BBC Radio 4 discussing Arthur Conan Doyle. Together with Linda Turner, I teach how the 'Science of Deduction' can be applied to medicine.
I contribute to public understanding of research through work with the Science Media Centre.
Nationally, I work with the Royal Colleges of Physicians as part of the MRCP(UK) Specialty Question Writing Group, and sit on the Association of British Neurologists Research Committee.