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Research project

Bioengineering to combat the tuberculosis pandemic

Project overview

We will combine engineering and biological approaches to investigate the host-pathogen interaction and identify new therapeutic targets.

Staff

Lead researcher

Professor Paul Elkington

Director of Inst. for Medical Innovation

Research interests

  • tuberculosis
  • immunopathology
  • diagnosis
Other researchers

Professor Xunli Zhang PhD, DIC, FRSC, CChem, CEng

Head of Department-Chemical Engineerg

Research interests

  • Xunli’s key expertise lies in the area of microfluidics technology from design and fabrication of microfluidic devices, through the development of in-situ monitoring methods for bio/chemical processes, to microfluidic modelling, microsystems integration and automation. The application is largely associated with biomedical challenges like patient specific design of microfluidic devices for cancer treatment, rapid diagnosis, and tackling antimicrobial resistance (AMR). The continuous flow reactors have been used for the synthesis of a range of nanoparticles, both organic and inorganic, for application in drug delivery and energy saving. The technologies developed in his research have also found great potential for industrial applications through a variety of industrial collaborations. 

Research outputs

NF Walker,
F Karim,
MY Moosa,
S Moodley,
M Mazibuko,
K Khan,
TR Sterling,
YF van der Heijden,
AD Grant,
A Pym,
& A Leslie
, 2022 , The Journal of Infectious Diseases , 226 (5) , 928--932
Type: article
Mohamed Ahmed,
Jared Mackenzie,
Robert Krause,
Barry Truebody,
Katya Govender,
John Adamson,
Hayden Fisher,
Adrie J. C. Steyn,
& Alasdair Leslie
, 2022 , Communications Biology , 5 (1317)
Type: article
Mohamed Ahmed,
Jared Mackenzie,
Robert Krause,
Barry Truebody,
Andres F. Vallejo,
Katya Govender,
John Adamson,
Hayden Fisher,
Adrie Steyn,
& Alasdair Leslie
, 2022 , Communications Biology
Type: article
Tommaso Morelli,
Kohei Fujita,
Gil Redelman-Sidi,
, 2021 , Thorax
Type: article
Marta Polak,
& Alasdair Leslie
, 2021 , Trends in Molecular Medicine , 28 (2) , 143--154
Type: review
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