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Research project

Bioengineering to combat the tuberculosis pandemic

Project overview

We will combine engineering and biological approaches to investigate the host-pathogen interaction and identify new therapeutic targets.

Staff

Lead researchers

Professor Paul Elkington

Director of Inst. for Medical Innovation
Research interests
  • tuberculosis
  • immunopathology
  • diagnosis
Connect with Paul

Email: P.Elkington@soton.ac.uk

Other researchers

Professor Xunli Zhang PhD, DIC, FRSC, CChem, CEng

Professor of Bioengineering
Research interests
  • Microfluidics and Lab-on-a-Chip Technologies
  • Biomedical and Chemical Engineering
  • Nanomaterials
Connect with Xunli

Email: XL.Zhang@soton.ac.uk

Research outputs

Mycobacterium tuberculosis senses host Interferon-γ via the membrane protein MmpL10
Mohamed Ahmed, Jared Mackenzie, Liku Bekele Tezera, Robert Krause, Barry Truebody, Diana Garay Baquero, Andres Vallejo Pulido, Katya Govender, John Adamson, Hayden Fisher, Jonathan W. Essex, Salah Mansour, Paul Elkington, Adrie J. C. Steyn & Alasdair Leslie, 2022, Communications Biology, 5(1317)
DOI: 10.1038/s42003-022-04265-0
Type: article
Elevated plasma matrix metalloproteinase-8 associates with sputum culture positivity in pulmonary tuberculosis
NF Walker, F Karim, MY Moosa, S Moodley, M Mazibuko, K Khan, TR Sterling, YF van der Heijden, AD Grant, Paul Elkington, A Pym & A Leslie, 2022, The Journal of Infectious Diseases, 226(5), 928-932
DOI: 10.1093/infdis/jiac160
Type: article
Understanding the Tuberculosis granuloma: the Matrix revolutions
Paul Elkington, Marta Polak, MT Reichmann & Alasdair Leslie, 2021, Trends in Molecular Medicine, 28(2), 143-154
DOI: 10.1016/j.molmed.2021.11.004
Type: review
Powered respirators are effective, sustainable, and cost-effective personal protective equipment for SARS-CoV-2
Alasdair Munro, Jacqui Prieto, Emmanouil Mentzakis, Mohammed AM Mansour, Nitin Mahobia, Peter Baker, Sarah Herbert, Trevor Smith, Matthew Hine, Joann Hall, Angie McClarren, Mike Davidson, Julie Brooks, Jane Fisher, David Griffiths, Hywel Morgan, Corrado Giulietti, Saul Faust & Paul Elkington, 2021, Frontiers in Medical Technology, 3(October 2021), 1-13
DOI: 10.3389/fmedt.2021.729658
Type: article
Infections due to Dysregulated Immunity: An emerging complication of Cancer Immunotherapy
Tommaso Geraldo Morelli, Kohei Fujita, Gil Redelman-Sidi & Paul Elkington, 2021, Thorax
DOI: 10.1136/thoraxjnl-2021-217260
Type: article
Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets
Michaela T. Reichmann, Liku Bekele Tezera, Andres Vallejo Pulido, Milica Vukmirovic, Rui Xiao, James Reynolds, Sanjay Jogai, Susan Wilson, Benjamin Marshall, Mark Jones, Alasdair Leslie, Jeanine M. D'Armiento, Naftali Kaminski, Marta Polak & Paul Elkington, 2021, Journal of Clinical Investigation, 131(15), 1-16
DOI: 10.1172/JCI148136
Type: article
Doxycycline host-directed therapy in human pulmonary tuberculosis
Quig Miow, Andres Vallejo Pulido, Yu Wang, Jia Hong, Chen Bai, Felicia Teo, Alvin Wang, Hong Loh, Tuan Tan, Ying Ding, Hoi She, Suay Gan, Nicholas Paton, Josephine Lum, Alicia Tay, Cynthia Chee, Paul Tambyah, Marta Polak, Yee Wang, Amit Singhal, Paul Elkington, Jon S. Friedland & Catherine W.M. Ong, 2021, Journal of Clinical Investigation, 131(15)
DOI: 10.1172/JCI141895
Type: article