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Research project

CRUK - Targeting Myeloid Cells For Improved Antibody Immunotherapy - DRCRPG-May23/100001

Staff

Lead researcher

Professor Mark Cragg

Professor in Experimental Cancer Biology

Research interests

  • Antibody biology
  • Antibody engineering
  • Cancer Immunotherapy
Other researchers

Dr Stephen Thirdborough

Senior Research Fellow

Professor Stephen Beers

Professor of Immunology & Immunotherapy

Research interests

  • Edit
  • Antibody Effector Functions Monoclonal antibodies (mAb) have become established in the treatment of a variety of malignancies - transforming patient outcomes. Despite this undoubted impact, responses remain variable and their mechanisms of action and of tumour resistance are controversial. Our research is focussed on understanding these complex processes using a variety of complementary models and systems to better inform antibody selection, design and clinical application.
  • Current research interests:

Professor Jon Strefford PhD

Head of School

Dr Matthew Carter

Senior Research Fellow

Professor Sean Lim

Professor of Haematology

Dr Jonathan West

Associate Professor

Research interests

  • Platelet Diversity The lab has a keen interest in understanding the nature and consequences of platelet functional diversity. Using a droplet microfluidics strategy we can measure intrinsic platelet behaviour. Broad-continuum sensitivity was identified, with hypersensitive platelets able to drive heterotypic system polarisation. Current research aims at characterising platelet dynamics and transcriptome remodelling in response to stimulation to pin-point sub-populations governing thrombosis.

Dr Yury Bogdanov

Lecturer in Transgenic Technologies

Research interests

  • Tumour microenvironment
  • Neurotransmitters in Cancer
  • GABA and GABA receptors
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