Dr Bogdanov has joined the University of Southampton in 2015. His main research interest is the role of neurotransmitters, in particular GABA, in tumour microenvironment and their effects on immune system.
- Tumour microenvironment
- Neurotransmitters in Cancer
- GABA and GABA receptors
It is now widely acknowledged that various neurotransmitters play an important role outside the central nervous system. One of the inhibitory neurotransmitters, GABA, modulates various functions of immune cells. it inhibits T cell proliferation, TNFalpha and IFNgamma production etc. It is postulated that GABA signalling is immunosupressive.
Various tumours including colon, breast and prostate produce excessive amounts of GABA thus inhibiting the ability of immune system to fight cancer.
Dr Bogdanov research is focused on the understanding the biology of GABAergic signalling in immune cells and cancer with the view to modify the ability of immune cells to fight GABA rich cancers.
Dr Bogdanov delivers lectures and tutorials for Foundation of Medicine module, Nutrition and Metabolism tutorials and Breast Cancer tutorials. He also delivers lectures for Biomedical Technology course.
Dr Bogdanov was appointed as Lecturer in Transgenic Technologies in 2015.
Dr Bogdanov graduated from Kharkov National University in 1991 majoring in genetics. He then moved to Engelhardt Institute of Molecular Biology where he completed his PhD in molecular biology in 1995. After completing his PhD he worked at the University College London on ATP receptors and calcium channels and then at University of Pennsylvania to work on GABA receptor biology. Dr Bogdanov is an expert in neuroscience, molecular biology and genetically modified animals.
Dr Bogdanov is interested in two main areas – modulating GABAergic signaling in the immune system to augment immunotherapy of solid tumors and developing new animal models for cancer research.