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Research project

Dr H M Haitchi ADAM33 gene and environmental interactions in developing lungs and their involvement in the early life origin of asthma

Staff

Lead researcher

Dr Hans Michael Haitchi MD, MMed(INT), PhD, PD, MRCP(London), FHEA, PGcert

Associate Professor

Research interests

  • Study of the asthma susceptibility gene A Disintegrin and Metalloprotease 33 (ADAM33) in early life and adult asthma and other chronic lung diseases.
  • Development of novel Anti-ADAM33 agents as potential disease modifying asthma therapy.
  • Multiomic study of the influence of the maternal environment (e.g. allergic asthma, obesity) during pregnancy on ADAM33 and other mediators and the early origin of lung disease in the Maternal Environment in Pregnancy (MEP) cohort.

Research outputs

Spiruchostatin A inhibits proliferation and differentiation of fibroblasts from patients with pulmonary fibrosis
Elizabeth R. Davies,
Hans Michael Haitchi,
Thomas H. Thatcher,
Patricia J. Sime,
R. Matthew Kottmann,
Arasu Ganesan,
Graham Packham,
Katherine M.A. O'Reilly,
& Donna E. Davies
, 2012 , American Journal of Respiratory Cell and Molecular Biology , 46 (5) , 687--694
DOI: 10.1165/rcmb.2011-0040OC
Type: article
ADAM33
Hans Michael Haitchi,
& Donna E. Davies
, 2012
DOI: 10.1016/B978-0-12-382219-2.00257-X
Type: bookChapter
SAM-pointed domain ETS factor mediates epithelial cell-intrinsic innate immune signaling during airway mucous metaplasia
T.R. Korfhagen,
J. Kitzmiller,
G. Chen,
A. Sridharan,
H.M. Haitchi,
R.S. Hegde,
S. Divanovic,
C.L. Karp,
& J.A. Whitsett
, 2012 , Proceedings of the National Academy of Sciences , 109 (41) , 16630--16635
DOI: 10.1073/pnas.1208092109
Type: article
Resistin‐like molecule‐β is induced following bronchoconstriction of asthmatic airways
Christopher L. Grainge,
Valdeep Dulay,
Jonathan Ward,
David Sammut,
Elizabeth Davies,
Benjamin Green,
Laurie C.K. Lau,
Laura Cottey,
Hans-Michael Haitchi,
Donna E. Davies,
& Peter H. Howarth
, 2012 , Respirology , 17 (7) , 1094--1100
DOI: 10.1111/j.1440-1843.2012.02215.x
Type: article
Regulation of a disintegrin and metalloprotease-33 expression by transforming growth factor-?
Youwen Yang,
James Wicks,
Hans Michael Haitchi,
Robert M. Powell,
Wiparat Manuyakorn,
Peter H. Howarth,
Stephen T. Holgate,
& Donna E. Davies
, 2012 , American Journal of Respiratory Cell and Molecular Biology , 46 (5) , 633--640
DOI: 10.1165/rcmb.2011-0030OC
Type: article