Skip to main navigationSkip to main content
The University of Southampton
Southampton Health Technology Assessments CentreNews

New SHTAC report on randomised controlled trials for policy interventions: a review of reviews and meta-regression

Published: 10 May 2010
New SHTAC report

Methodological research into the comparability of effect sizes of policy interventions evaluated by random and non-randomised controlled trials has now been published in the Health Technology Assessment monograph series.

Methodological research into the comparability of effect sizes of policy interventions evaluated by random and non-randomised controlled trials has now been published in the Health Technology Assessment monograph series. The project comprised a review of the methodological literature, a systematic review of meta-analyses comparing random and non-randomised designs, re-sampling of data from two randomised controlled trials, and meta-epidemiological methods involving meta-regression. The study found that effect sizes from randomised and non-randomised controlled trials may differ in some circumstances and that these differences may be associated with factors confounded with design. The project was a collaboration between SHTAC and the Social Science Research Unit at the Institute of Education in London, the Centre for Reviews and Dissemination at the University of York, and the Medical Research Council Biostatistics Unit at the Institute of Public Health in Cambridge.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×