Skip to main navigationSkip to main content
The University of Southampton
Southampton Health Technology Assessments CentreNews

“Short, concise, and totally on point” - new SHTAC report on recombinant human growth hormone for growth disorders in children

Published: 13 January 2011
SHTAC receives recognition

The SHTAC systematic review and economic evaluation of recombinant human growth hormone for the treatment of growth disorders in children has received international recognition.

A systematic review and economic evaluation of the clinical and cost-effectiveness of recombinant human growth hormone for the treatment of growth disorders in children has been published in Health Technology Assessment. The project was commissioned by the NIHR Health Technology Assessment programme.

The study found that treatment with recombinant human growth hormone gave significantly greater benefits in stature for children with growth hormone deficiency (GHD), Turner syndrome, Prader-Willi syndrome, chronic renal insufficiency, short stature homeobox-containing gene deficiency, and those who were small for gestational age, than for untreated children. However, treatment was considered to be cost-effective at a willingness to pay threshold of £20,000-30,000 per quality-adjusted life-year gained only for children with GHD, although the analysis is subject to a range of important uncertainties.

The British Medical Journal Evidence Centre recently reviewed the report as part of their ‘Evidence Update' series. The report was rated highly according to relevance to practice and newsworthiness, and favourable comments were made by clinical raters including:

"Short, concise, and totally on point"

and

"Outstanding systematic review and compilation of the literature. A must read for people interested in potential use or otherwise of GH".

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×