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The University of Southampton
Southampton Health Technology Assessments Centre

Research in progress

SHTAC is currently working on a wide range of projects. 

Where available, click the link below for further information on each project.

Technology Assessment Reports for NICE 

A number of projects have been paused while priority is given to reviews on the diagnosis and treatment of COVID-19  - the summary below indicates if a project is paused or active

ProjectEstimated publication date 

Afamelanotide for treating protoporphyria ACTIVE

2020 

Budesonide for treating active eosinophilic oesophagitis PAUSED

2020

Ustekinumab for treating moderately to severely active ulcerative colitis PAUSED

2020

Pembrolizumab with axitinib for untreated metastatic renal cell carcinoma ACTIVE

2020

Dupilumab for treating severe asthma ACTIVE

2020

Emapalumab for treating primary haemophagocytic lymphohistiocytosis ACTIVE

2020

Solriamfetol for treating excessive waketime sleepiness caused by narcolepsy PAUSED

2020

Avapritinib for treating unresectable or metastatic gastrointestinal stromal  tumours ACTIVE

2020

Solriamfetol fortreating excessive waketime sleepiness caused by obstructive sleep apneoa ACTIVE

2021

Apalutamide for treating prostate cancer ACTIVE

2021

 

Research - Other projects

 Project

Funder

SHTAC Contact

Interventions for encouraging sexual behaviours intended to prevent cervical cancer (Cochrane systematic review update)                                 SHTAC Dr Jonathan Shepherd
CONFIRM - Checkpoint blockade for inhibition of relapsed mesothelioma: A phase III trial to evaluate the efficacy of nivolumab in relapsed mesothelioma Cancer Research UK Prof Joanne Lord
EACH-B - Engaging adolescents in changing behaviour NIHR Programme Grant for Applied Research   Prof Joanne Lord
CASA-AF - Catheter ablation versus thoracoscopic surgical ablation in long standing persistent atrial fibrillation

NIHR Efficacy and Mechanism  Evaluation Programme  Prof Joanne Lord
Endobarrier - Controlled trial of a duodenal sleeve bypass device (Endobarrier) compared with standard medical therapy for the management of obese subjects with type 2 diabetes NIHR Efficacy and Mechanism  Evaluation Programme  Prof Joanne Lord
ATTACK - Aspirin To Target Arterial Events in Chronic Kidney Disease NIHR Health Technology Assessment Programme & British Heart Foundation Prof Joanne Lord

Optimising Cardiac Surgery ouTcOmes in People with diabeteS (OCTOPuS)

NIHR Health Technology Assessment Programme Dr Jo Picot

Nudging healthier dietary habits: evaluation of a supermarket placement strategy in the WRAPPED study

NIHR Public Health Research Programme Prof Joanne Lord

A feasibility trial of serial prophylactic exchange blood transfusion (SPEBT) in pregnant women with sickle cell disease (SCD) aiming to improve maternal and infant outcomes 

NIHR Research for Patient Benefit Programme Maria Chorozoglou

EMPRESS: A feasibility study of Very Early Mobilisation PRogrammES in Critical Care

NIHR Research for Patient Benefit Programme Maria Chorozoglou

Rapid review of the effectiveness of digital tools to improve recruitment and retention of participants in randomised controlled trials in health

NIHR CTU Support Funding Dr Jonathan Shepherd & Dr Geoff Frampton

FAIR - FLAGELLIN AEROSOL THERAPY AS AN IMMUNOMODULATORY ADJUNCT TO THE ANTIBIOTIC TREATMENT OF DRUG-RESISTANT BACTERIAL PNEUMONIA

European Commission Horizon 2020 Framework Programme Prof Joanne Lord & Dr Jo Picot
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