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The University of Southampton
Southampton Health Technology Assessments Centre

Research in progress

SHTAC is currently working on a wide range of projects. 

Where available, click the link below for further information on each project.

Technology Assessment Reports for NICE

ProjectEstimated publication date 

Afamelanotide for treating protoporphyria


Budesonide for treating active eosinophilic oesophagitis


Ustekinumab for treating moderately to severely active ulcerative colitis


Pembrolizumab with axitinib for untreated metastatic renal cell carcinoma


Dupilumab for treating severe asthma


Emapalumab for treating primary haemophagocytic lymphohistiocytosis


Research - Other projects



SHTAC Contact

Interventions for encouraging sexual behaviours intended to prevent cervical cancer (Cochrane systematic review update)                                 SHTAC Dr Jonathan Shepherd
CONFIRM - Checkpoint blockade for inhibition of relapsed mesothelioma: A phase III trial to evaluate the efficacy of nivolumab in relapsed mesothelioma Cancer Research UK Prof Joanne Lord
EACH-B - Engaging adolescents in changing behaviour NIHR Programme Grant for Applied Research   Prof Joanne Lord
CASA-AF - Catheter ablation versus thoracoscopic surgical ablation in long standing persistent atrial fibrillation

NIHR Efficacy and Mechanism  Evaluation Programme  Prof Joanne Lord
Endobarrier - Controlled trial of a duodenal sleeve bypass device (Endobarrier) compared with standard medical therapy for the management of obese subjects with type 2 diabetes NIHR Efficacy and Mechanism  Evaluation Programme  Prof Joanne Lord
ATTACK - Aspirin To Target Arterial Events in Chronic Kidney Disease NIHR Health Technology Assessment Programme & British Heart Foundation Prof Joanne Lord

Optimising Cardiac Surgery ouTcOmes in People with diabeteS (OCTOPuS)

NIHR Health Technology Assessment Programme Dr Jo Picot

Nudging healthier dietary habits: evaluation of a supermarket placement strategy in the WRAPPED study

NIHR Public Health Research Programme Prof Joanne Lord

A feasibility trial of serial prophylactic exchange blood transfusion (SPEBT) in pregnant women with sickle cell disease (SCD) aiming to improve maternal and infant outcomes 

NIHR Research for Patient Benefit Programme Maria Chorozoglou

EMPRESS: A feasibility study of Very Early Mobilisation PRogrammES in Critical Care

NIHR Research for Patient Benefit Programme Maria Chorozoglou

Rapid review of the effectiveness of digital tools to improve recruitment and retention of participants in randomised controlled trials in health 

NIHR CTU Support Funding Dr Jonathan Shepherd & Dr Geoff Frampton


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