Phone:: (023) 8059 3221
Email:: ds@isvr.soton.ac.uk

Prof David Simpson BSc, PhD, MIPEM

Professor of Biomedical Signal Processing

Related links

Prof David Simpson is Professor of Biomedical Signal Processing within Engineering and the Environment at the University of Southampton.

The Biomedical engineering provides a stimulating mix of 'hard' science and engineering with the excitement of understanding biology better and the motivation to help patients.

His research and teaching focus on the application of engineering techniques (primarily those for data analysis using computing methods) in a medical context.

After schooling in Austria, he graduated in Biomedical Electronics from the University of Salford (1981) and then worked as a mathematics and physics teacher in Nigeria. He obtained his PhD in Electrical Engineering from Imperial College of Science, Technology and Medicine, University of London in 1988. From 1989 to 1998 he lectured in the Biomedical Engineering Program at the Federal University of Rio de Janeiro (Brazil), before becoming a research fellow in the Medical Physics Department of Leicester Royal Infirmary. He moved to the University of Southampton (ISVR) in 2001.

Research

Publications

Teaching

Contact

Research interests

Stochastic signal processing algorithms (methods for the analysis of random signals)
The control system regulating blood pressure, heart-rate, respiration and blood flow in the brain
Auditory Evoked Potentials (the responses of the brain to auditory stimulation)
Neuromuscular control of limb movements in humans and insects (locusts)
Improving hearing aids and cochlear implants

David Simpson's research aims to improve the care of patients. To this end he develops and applies signal processing methods that extract diagnostic information from complex biomedical signals (e.g. from traces of ECG or blood pressure) and improves the understanding of physiology and hence innovative diagnostic methods.

Photograph of Prof David Simpson — Figure 1

Figure 1: The analysis of biomedical signals provides new insights into physiology and paves the way to new diagnostic techniques.

Research group

Human Sciences Group

Affiliate research group

Signal Processing and Control Group

Research project(s)

Anaesthesia and awareness

Occasionally people wake up during surgery, which is highly distressing. It is a particular problem when a muscle relaxant is given as people are unable to move to tell people that they are awake. We hope to develop methods that can tell if people are awake in operations using either the brain response to sound, or the patterns of connection in the brain.

The Hearing Brain

It is possible to measure the electrical response of the brain to sound. However the signals are very small and can be swamped by electrical activity from rest of the body. In this project we are developing better methods to measure the tiny signals and exploring their clinical applications.

2 ears are better than 1

What benefit do hearing impaired people get from using two auditory prostheses, one in each ear?

Improving the acquisition of Auditory Evoked Potentials for clinical diagnosis

New methods for assessing the control of blood flow in the brain

Objective measures of hearing aid benefit

Quantitative measurements of impairment and how they relate to activity in the upper limb of the older adult post-stroke

Modelling of the neuronal responses of identified motor neurons across animals

Independent component analysis in the automated detection of evoked potentials from multichannel recording

What are hearing aids up to?

Developing methods to measure the performance of advanced features in hearing aids/cochlear implants and to predict how much they will benefit patients.

Muscle models with applications

How can we improve existing muscle models and use these to detect the effect of therapies, medicines, and any other external factor on muscle performances?

Diversity in blood flow control to the brain

Articles

Mahdi, A., Nikolic, D., Birch, A. A., Olufsen, M., Panerai, R. B., Simpson, D. M., & Payne, S. J. (2017). Increased blood pressure variability upon standing up improves reproducibility of cerebral autoregulation indices. Medical Engineering & Physics. DOI: 10.1016/j.medengphy.2017.06.006

Costalago-meruelo, A., Simpson, D. M., Veres, S. M., & Newland, P. L. (2017). Predictive control of intersegmental tarsal movements in an insect. Journal of Computational Neuroscience. DOI: 10.1007/s10827-017-0644-x

Costalago Meruelo, A., Simpson, D., Veres, S., & Newland, P. (2016). Improved system identification using artificial neural networks and analysis of individual differences in responses of an identified neuron. Neural Networks, 75, 56-65. DOI: 10.1016/j.neunet.2015.12.002

Katsogridakis, E., Simpson, D. M., Bush, G., Fan, L., Birch, A. A., Allen, R., ... Panerai, R. B. (2016). Revisiting the frequency domain: the multiple and partial coherence of cerebral blood flow velocity in the assessment of dynamic cerebral autoregulation. Physiological Measurement, 37(7), 1056-1073. DOI: 10.1088/0967-3334/37/7/1056

Claassen, J. A. H. R., Meel-van den Abeelen, A. S. S., Simpson, D., & Panerai, R. B. (2016). Transfer function analysis of dynamic cerebral autoregulation: A white paper from the International Cerebral Autoregulation Research Network. Journal of Cerebral Blood Flow & Metabolism, 36(4), 665-680. DOI: 10.1177/0271678X15626425

Endo, W., Santos, F. P., Simpson, D., Maciel, C. D., & Newland, P. L. (2015). Delayed mutual information infers patterns of synaptic connectivity in a proprioceptive neural network. Journal of Computational Neuroscience, 38(2), 427-438. DOI: 10.1007/s10827-015-0548-6

Hosseini, P. T., Bell, S., Wang, S., & Simpson, D. (2015). Induced activity in EEG in response to auditory stimulation. Biomedical Signal Processing and Control, 22, 31-43. DOI: 10.1016/j.bspc.2015.06.005

Meel-van den Abeelen, A. S. S., Simpson, D. M., Wang, L. J. Y., Slump, C. H., Zhang, R., Tarumi, T., ... Claassen, J. A. H. R. (2014). Between-centre variability in transfer function analysis, a widely used method for linear quantification of the dynamic pressure–flow relation: the CARNet study. Medical Engineering & Physics, 36(5), 620-627. DOI: 10.1016/j.medengphy.2014.02.002

Angarita-Jaimes, N., Kouchakpour, H., Liu, J., Panerai, R. B., & Simpson, D. M. (2014). Optimising the assessment of cerebral autoregulation from black box models. Medical Engineering & Physics, 36(5), 607-612. DOI: 10.1016/j.medengphy.2013.12.012

Liu, J., Simpson, D. M., Kouchakpour, H., Panerai, R. B., Chen, J., Gao, S., ... Wu, X. (2014). Rapid pressure-to-flow dynamics of cerebral autoregulation induced by instantaneous changes of arterial CO2. Medical Engineering & Physics, 36(12), 1636-1643. DOI: 10.1016/j.medengphy.2014.09.005

Hosseini, P. T., Wang, S., Brinton, J., Bell, S., & Simpson, D. M. (2014). Reliability of dynamic causal modeling using the statistical parametric mapping toolbox. International Journal of System Dynamics Applications, 3(2), 1-16. DOI: 10.4018/ijsda.2014040101

Fan, L., Bush, G., Katsogridakis, E., Simpson, D. M., Allen, R., Potter, J., ... Panerai, R. B. (2013). Adaptive feedback analysis and control of programmable stimuli for assessment of cerebrovascular function. Medical and Biological Engineering and Computing, 51(6), 709-718. DOI: 10.1007/s11517-013-1040-y

Katsogridakis, E., Bush, G., Fan, L., Birch, A. A., Simpson, D. M., Allen, R., ... Panerai, R. B. (2013). Detection of impaired cerebral autoregulation improves by increasing arterial blood pressure variability. Journal of Cerebral Blood Flow & Metabolism, 33(4), 519-523. DOI: 10.1038/jcbfm.2012.191

Fonseca, D. S., Beda, A., Miranda de Sá, A. M. F. L., & Simpson, D. M. (2013). Gain and coherence estimates between respiration and heart-rate: Differences between inspiration and expiration. Autonomic Neuroscience, 178(1-2), 89-95. DOI: 10.1016/j.autneu.2013.03.015

Vaughan, A., Rowan, D., & Simpson, D. M. (2013). Investigating evidence of sound localisation using bone conduction stimulation. International Journal of Audiology, 52(4), 295. DOI: 10.3109/14992027.2013.765042

Beda, A., Simpson, D. M., Carvalho, N. C., & Carvalho, A. R. S. (2013). Low-frequency heart rate variability is related to the breath-to-breath variability in the respiratory pattern. Psychophysiology, 51(2), 197-205. DOI: 10.1111/psyp.12163

L'Esperance, V. S., Cox, S. E., Simpson, D. M., Gill, C. A., Makani, J., Soka, D., ... Clough, G. F. (2013). Peripheral vascular response to inspiratory breath hold in paediatric homozygous sickle cell disease. Experimental Physiology, 98(1), 49-56. DOI: 10.1113/expphysiol.2011.064055

Motamedi-Fakhr, S., Moshrefi-Torbati, M., Hill, M., Simpson, D., S Bucks, R. S., Paul, A., & Hill, C. M. (2013). Respiratory cycle related EEG changes: modified respiratory cycle segmentation. Biomedical Signal Processing and Control, 8(6), 838-844. DOI: 10.1016/j.bspc.2013.08.001

Dewhirst, O. P., Angarita, N., Simpson, D. M., Allan, R., & Newland, P. L. (2012). A system identification analysis of neural adaptation dynamics and nonlinear responses in the local reflex control of locust hind limbs. Journal of Computational Neuroscience, 34(1), 39-58. DOI: 10.1007/s10827-012-0405-9

Beda, A., Güldner, A., Simpson, D. M., Carvalho, N. C., Franke, S., Uhlig, C., ... de Abreu, M. G. (2012). Effects of assisted and variable mechanical ventilation on cardiorespiratory interactions in anesthetized pigs. Physiological Measurement, 33(3), 503-519. DOI: 10.1088/0967-3334/33/3/503

Manders, A., Simpson, D. M., & Bell, S. L. (2012). Objective prediction of the sound quality of music processed by an adaptive feedback canceller. IEEE Transactions on Audio, Speech and Language Processing, 20(6), 1734-1745. DOI: 10.1109/TASL.2012.2188513

Katsogridakis, E., Bush, G., Fan, L., Birch, A. A., Simpson, D. M., Allen, R., ... Panerai, R. B. (2012). Random perturbations of arterial blood pressure for the assessment of dynamic cerebral autoregulation. Physiological Measurement, 33(2), 103-116. DOI: 10.1088/0967-3334/33/2/103

Angarita-Jaimes, N., Dewhirst, O., Simpson, D. M., Kondoh, Y., Allen, R., & Newland, P. (2012). The dynamics of analogue signalling in local networks controlling limb movement. European Journal of Neuroscience, 36(9), 3269-3282. DOI: 10.1111/j.1460-9568.2012.08236.x

Jing, X. J., Simpson, D. M., Allen, R., & Newland, P. L. (2012). Understanding neuronal systems in movement control using Wiener/Volterra kernels: a dominant feature analysis. Journal of Neuroscience Methods, 203, 220-232. DOI: 10.1016/j.jneumeth.2011.09.014

Vidal-Gadea, A. G., Jing, X. J., Simpson, D. M., Dewhirst, O. P., Kondoh, Y., Allen, R., & Newland, P. L. (2010). Coding characteristics of spiking local interneurons during imposed limb movements in the locust. Journal of Neurophysiology, 103(2), 603-615. DOI: 10.1152/jn.00510.2009

Clough, G. F., Avery, M. R., Voegeli, D., Byrne, C. D., & Simpson, D. M. (2010). Cutaneous vascular response to local warming: a response to letter from Cracowski and Roustit. Microcirculation, 17(2), 81-82. DOI: 10.1111/j.1549-8719.2010.00019.x

Turk, R., Simpson, D. M., & Burridge, J. H. (2010). The association between muscle activation patterns, wrist tracking performance and upper limb function in post-stroke hemiplegia. Clinical Rehabilitation, 24(3), 284. DOI: 10.1177/0269215509352055

Liu, J., Simpson, M. D., Yan, J., & Allen, R. (2010). Tracking time-varying cerebral autoregulation in response to changes in respiratory PaCO2. Physiological Measurement, 31(10), 1291-1307. DOI: 10.1088/0967-3334/31/10/001

Avery, M. R., Voegeli, D., Simpson, D., Clough, G. F., & Byrne, C. D. (2009). Age and cigarette smoking are independently associated with the cutaneous vascular response to local warming. Microcirculation, 16(8), 725-734. DOI: 10.3109/10739680903199194

Oliveira, L. F., Vieira, T. M. M., Macedo, A. R., Simpson, D. M., & Nadal, J. (2009). Postural sway changes during pregnancy. European Journal of Obstetrics, Gynecology and Reproductive Biology, 147(1), 25-28. DOI: 10.1016/j.ejogrb.2009.06.027

Burridge, J. H., Turk, R., Notley, S. V., Pickering, R. M., & Simpson, D. M. (2009). The relationship between upper limb activity and impairment in post-stroke hemiplegia. Disability and Rehabilitation, 31(2), 109-117. DOI: 10.1080/09638280701824699

Botero Rosas, D. A., Infantosi, A. F. C., Simpson, D. M., & Maldonado Arango, M. I. (2008). EEG and cerebral blood flow in newborns during quiet sleep. International Journal of Bioelectromagnetism, 10(4), 261-268.

Turk, R., Notley, S. V., Pickering, R. M., Simpson, D. M., Wright, P. A., & Burridge, J. H. (2008). Reliability and sensitivity of a wrist rig to measure motor control and spasticity in post-stroke hemiplegia. Neurorehabilitation and Neural Repair, 22(6), 684-696. DOI: 10.1177/1545968308315599

Jones, A., Beda, A., Osmond, C., Godfrey, K. M., Simpson, D. M., & Phillips, D. I. W. (2008). Sex-specific programming of cardiovascular physiology in children. European Heart Journal, 29(17), 2164-2170. DOI: 10.1093/eurheartj/ehn292

Notley, S. V., Turk, R., Pickering, R., Simpson, D. M., & Burridge, J. H. (2007). Analysis of the quality of wrist movement during a simple tracking task. Physiological Measurement, 28(8), 881-895. DOI: 10.1088/0967-3334/28/8/011

Beda, A., Jandre, F. C., Phillips, D. I., Giannella-Neto, A., & Simpson, D. M. (2007). Heart-rate and blood-pressure variability during psychophysiological tasks involving speech: influence of respiration. Psychophysiology, 44(5), 767-778. DOI: 10.1111/j.1469-8986.2007.00542.x

Lv, J., Simpson, D. M., & Bell, S. L. (2007). Objective detection of evoked potentials using a bootstrap technique. Medical Engineering & Physics, 29(2), 191-198. DOI: 10.1016/j.medengphy.2006.03.001

Fisher, A. C., Simpson, D. M., Hagan, R. P., & Brown, M. C. (2007). Optimising the detection of transient evoked potentials using a bootstrap re-sampling technique to provide an objective measure of signal recovery. Documenta Ophthalmologica: Abstracts of the XLV International Symposium of ISCEV, 115(1), 21-22. DOI: 10.1007/s10633-007-9069-6

Jones, A., Beda, A., Ward, A. M. V., Osmond, C., Phillips, D. I. W., Moore, V. M., & Simpson, D. M. (2007). Size at birth and autonomic function during psychological stress. Hypertension, 49(3), 548-555. DOI: 10.1161/01.HYP.0000257196.13485.9b

Simpson, D. M. (2006). Digital filtering: short tutorial guide. Scope, 15(1), 22-27.

Ramos, E. G., Simpson, D. M., Panerai, R. B., Nadal, J., Lopes, J. M. A., & Evans, D. H. (2006). Objective selection of signals for assessment of cerebral blood flow autoregulation in neonates. Physiological Measurement, 27(1), 35-49. DOI: 10.1088/0967-3334/27/1/004

Simpson, D. M., Rosas, D. A. B., & Infantosi, A. F. C. (2005). Estimation of coherence between blood flow and spontaneous EEG activity in neonates. IEEE Transactions on Biomedical Engineering, 52(5), 852-858. DOI: 10.1109/TBME.2005.845368

Liu, J., Simpson, D. M., & Allen, R. (2005). High spontaneous fluctuation in arterial blood pressure improves the assessment of cerebral autoregulation. Physiological Measurement, 26(5), 725-741. DOI: 10.1088/0967-3334/26/5/012

Simpson, D. M., & De Stefano, A. (2004). A tutorial review of the fourier transform. Scope, 13(1), 28-33.

Simpson, D. M., Panerai, R. B., Ramos, E. G., Lopes, J. M. A., Villar Marinatto, M. N., Nadal, J., & Evans, D. H. (2004). Assessing blood flow control through a bootstrap method. IEEE Transactions on Biomedical Engineering, 51(7), 1284-1286. DOI: 10.1109/TBME.2004.827947

Simpson, D. M., & DeStefano, A. (2004). Digitising signals - a short tutorial guide. SCOPE, 13(4), 9-16.

Simpson, D. M., & De Stefano, A. (2004). Digitizing signals - a short tutorial guide. SCOPE, 13(4), 9-15.

Simpson, D. M. (2003). An introduction to digital filtering for electrophysiology. Journal of Electrophysiological Technology, 29(3), 208-218.

Botero Rosas, D. A., Catelli Infantosi, A. F., & Simpson, D. M. (2003). Software para investigar la regulación del flujo sanguíneo cerebral en niños recién nacidos [Software for research into the regulation of cerebral blood flow in newborns]. Revista de Salud por los Niños de las Americas (Saludarte), 3(9), 39-50.

Miranda de, S. A. M. F. L., Infantosi, A. F. C., & Simpson, D. M. (2002). Coherence between one random and one periodic signal for measuring the strength of responses in the electro-encephalogram during sensory stimulation. Medical and Biological Engineering and Computing, 40(1), 99-104.

Simpson, D. M., Panerai, R. B., Evans, D. H., & Naylor, A. R. (2001). A parametric approach to measuring cerebral blood flow autoregulation from spontaneous variations in blood pressure. Annals of Biomedical Engineering, 29(1), 18-25. DOI: 10.1114/1.1335537

Miranda de Sa, A. M. F. L., Infantosi, A. F. C., & Simpson, D. M. (2001). A statistical technique for measuring synchronism between corticalregions in the EEG during rhythmic stimulation. IEEE Transactions on Biomedical Engineering, 48(10), 1211-15. DOI: 10.1109/10.951526

Ramos, E. G., Nadal, J., Villar, M. N., Lopes, J. M. A., Simpson, D. M., Panerai, R. B., & Evans, D. H. (2001). Compara entre t?cnicas de avalia??o de auto-regula??o do fluxo sangu?neo cerebral de neonatos (Comparison between techniques to evaluate autoregulation of cerebral blood flow in neonates). Proceedings of the II Congreso Lationamericano de Ingenieria Biomédica, La Habana, 5.

Simpson, D. M., Infantosi, A. F. C., & Botero Rosas, D. A. (2001). Estimation and significance testing of cross-correlation between cerebral blood flow velocity and background electro-encephalograph activity in signals with missing samples. Medical and Biological Engineering and Computing, 39(4), 428-433. DOI: 10.1007/BF02345364

Lazarev, V. V., & Simpson, D. M. (2001). Individual frequency profile of photic driving in children and adolescents. Clinical Neurophysiology, 112(Supplement 1), p.S38. DOI: 10.1016/S1388-2457(01)80021-3

de Oliveira, C. G., Simpson, D. M., & Nadal, J. (2001). Lumbar back muscle activity of helicopter pilots and whole-body vibration. Journal of Biomechanics, 34(10), 1309-1315. DOI: 10.1016/S0021-9290(01)00090-2

Lazarev, V. V., Simpson, D. M., Schubesky, B. M., & De Azevedo, L. C. (2001). Photic driving in the electroencephalogram of children and adolescents: harmonic structure and relation to the resting state. Brazilian Journal of Medical and Biological Research, 34(12), 1573-1584.

Book

Diniz, P. S. R., Simpson, D. M., De Stefano, A., & Gismondi, R. C. (2003). Digital signal processing with application in medicine. Unesco.

Book Chapters

Simoes, J., Jesus, L., Voegeli, D., Martins, C., Hall, A., & Simpson, D. (2014). The effects of acoustic stimulation on comatose patients [reprint with corrections]. In Horizons in Neuroscience Research. (pp. 141-172). Waltham, US: Nova Biomedical.

Simoes, J., Jesus, L., Voegeli, D., Martins, C., Hall, A., & Simpson, D. (2012). The effects of acoustic stimulation on comatose patients. In Comas and Syncope: Causes, Prevention and Treatment. New York, US: Nova Publishing.

Diniz, P. S. R., Simpson, D. M., De Stefano, A., & Gismondi, R. C. (2003). Digital signal processing with applications in medicine, in Physical Sciences, Engineering and Technology Resources. In Encyclopedia of Life Support Systems (EOLSS) Online. Encyclopedia of Life Support Systems.

Conferences

Vanheusden, F., Bell, S., Chesnaye, M. A., & Simpson, D. (2017). Exploration of inter-individual variability in cortical responses to natural English sentences. Abstract from XXV International Evoked Response Audiometry Study Group Biennial Symposium, Krakow, Poland.

Vanheusden, F., Bell, S., Chesnaye, M. A., & Simpson, D. (2017). Multichannel frequency-domain Hotelling’s T2 test for detection of envelope following responses to natural vowels. Abstract from XXV International Evoked Response Audiometry Study Group Biennial Symposium, Krakow, Poland.

Vanheusden, F., Bell, S., Chesnaye, M. A., & Simpson, D. (2017). Simultaneous detection of envelope frequency following responses and cortical responses to words using the Hotelling’s T2 Test. Abstract from British Society of Audiology Annual Conference, Harrogate, United Kingdom.

Nikolic, D., Simpson, D., Katsogridakis, E., & Panerai, R. B. (2016). Assessing inter-subject variability in cerebral blood flow control measurements. In E. Kyriacou , S. Christofides , & C. Pattichis (Eds.), XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016. (pp. 29-32). (IFMBE Proceedings; Vol. 57). Springer. DOI: 10.1007/978-3-319-32703-7_6

Lioi, G., Bell, S., & Simpson, D. (2016). Changes in functional brain connectivity in the transition from wakefulness to sleep in different EEG bands. 3-8. Paper presented at XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016, Cyprus.DOI: 10.1007/978-3-319-32703-7_1

Nikolic, D., Birch, A., Panerai, R., & Simpson, D. (2015). Assessing cerebral blood flow control from variability in blood pressure and arterial CO2 levels. The 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS) 2015, .DOI: 10.1109/EMBC.2015.7318725

Jing, X. J., Angarita, N., Simpson, D. M., Allen, R., & Newland, P. L. (2011). A learning approach to identification of nonlinear physiological systems using wiener models. In Proceedings of Biosignals 2011 International Conference on Bio-inspired Systems and Signal Processing. (pp. 472-476). Springer.

Katsogridakis, E., Bush, G., Fan, L., Birch, A. A., Simpson, D. M., Allen, R., & Panerai, R. B. (2011). Assessment of cerebral autoregulation with the use of pseudorandom binary sequences. Paper presented at XXVth International Symposium on Cerebral Blood Flow, Metabolism and Function, Spain.

Arango Granados, M. C., Botero Rosas, D. A., Infantosi, A. F. C., & Simpson, D. M. (2011). Estimated relation between cerebral blood flow and background electroencephalogram activity signals with missing samples in neonates during quiet sleep. Paper presented at XXVth International Symposium on Cerebral Blood Flow, Metabolism and Function, Spain.

Simpson, D. M., Angarita-Jaimes, N., Kouchakpour, H., & Allen, R. (2011). Improved estimates of autoregulation from spontaneous variations in blood flow and pressure. Paper presented at XXVth International Symposium on Cerebral Blood Flow, Metabolism and Function, Spain.

Kouchakpour, H., Allen, R., & Simpson, D. M. (2011). Optimizing measures of autoregulation from spontaneously varying blood pressure and flow. Paper presented at Cerebral Haemodynamics: Measurement and Management, Institute of Physics and Engineering in Medicine, United Kingdom.

Angarita, N., & Simpson, D. M. (2011). Optimizing the assessment of cerebral autoregulation from linear and nonlinear models. In Proceedings of Biosignals 2011 International Conference on Bio-inspired Systems and Signal Processing. (pp. 251-256). Springer.

Dewhirst, O. P., Angarita, N., Simpson, D. M., Allen, R., & Newland, P. L. (2011). The dynamics of locust non-spiking local interneurons, responses to imposed limb movements. In Proceedings of Biosignals 2011 International Conference on Bio-inspired Systems and Signal Processing. (pp. 270-275). Springer.

Turk, R., Burridge, J. H., & Simpson, D. M. (2010). Exploring wrist motor control in stroke patients, using a target tracking task. Paper presented at Medical Physics and Engineering Conference and Bioengineering, United Kingdom.

Kouchakpour, H., Simpson, D. M., & Allen, R. (2010). New methods for assessing the control of blood flow in the brain. Poster session presented at 32nd IEEE Engineering in Medicine and Biology Conference (EMBS10), Argentina.

Anagarita-Jaimes, N. C., Dewhirst, O. P., & Simpson, D. M. (2010). Non-linear modeling of cerebral autoregulation using cascade models. In P. D. Bamidis, & N. Palllikarakis (Eds.), Proceedings of the 22nd Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2010. (pp. 93-96). (IFMBE Proceedings; Vol. 29). Springer.

Kouchakpour, H., Simpson, D. M., & Allen, R. (2010). Nonlinear, multiple-input modeling of cerebral autoregulation using Volterra Kernel estimation. Paper presented at 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society "Merging Medical Humanism and Technology", Argentina.

Turk, R., Simpson, D. M., & Burridge, J. H. (2010). Quantifying motor impairments at the wrist post-stroke: does finger position matter?. Paper presented at Society for Research in Rehabilitation Winter Meeting, United Kingdom.

Dewhirst, O. P., Simpson, D. M., Angarita, N., & Allen, R. P. L. (2010). Wiener-Hammerstein parameter estimation using differential evolution: Application to limb reflex dynamics. 6pp. Paper presented at 3rd International Conference on Bio-inspired Systems and Signal Processing, .

Turk, R., Simpson, D. M., & Burridge, J. H. (2010). Wrist motor control and coactivation during step-tracking in post-stroke hemiplegia and unimpaired adults. Paper presented at 18th International Conference of the Society of Electromyography and Kinesiology, Denmark.

Simpson, D. M., & Bell, S. L. (2009). A new method for the fast automated detection of evoked potentials. Paper presented at IPEM Medical Physics and Engineering Conference, United Kingdom.

Turk, R., Simpson, D. M., & Burridge, J. H. (2009). A pilot study to investigate the association between muscle activation patterns, wrist tracking performance and upper limb function in post-stroke hemiplegia. Paper presented at Society for Research in Rehabilitation Summer Meeting, United Kingdom.

Turk, R., Simpson, D. M., & Burridge, J. H. (2009). Coactivation during wrist movement: relationship with motor control and upper limb functional activity in post-stroke hemiplegia. Paper presented at Physiotherapy Research Society, United Kingdom.

Milner, R. P., Fisher, A. C., Austin, M. J., Small, A., Hagan, R. P., Brown, M. C., ... Simpson, D. M. (2009). Explicit detection of PERG above noise floor allows for early stopping of recording. Paper presented at 7th National Meeting of the British Society for Clinical Electrophysiology of Vision, United Kingdom.

Simpson, D. M. (2009). Invited tutorial: making the most of physiological signals recorded in the real world. IPEM Medical Physics and Engineering Conference, United Kingdom.

Dewhurst, O., Simpson, D. M., Allen, R., & Newland, P. (2009). Neuromuscular reflex control of limb movement - validating models of the locust's hind leg control system using physiological input signals. Paper presented at 4th International IEEE EMBS Conference on Neural Engineering, Turkey.

Manders, A., Simpson, D., & Bell, S. L. (2009). Objective measures of the sound quality of adaptive feedback cancellers in hearing aids (Poster). Paper presented at British Society of Audiology Short Papers Meeting on Experimental Studies of Hearing and Deafness, .

Simpson, D. M., Fisher, A. C., Milner, R. P., Hagan, R. P., & Austin, M. J. (2009). Objective methods for the detection of pattern electroretinograms (PERG). Paper presented at World Congress on Medical Physics and Biomedical Engineering, Germany.

Vidal-Gadea, A. G., Jing, X. J., Kondoh, Y., Simpson, D. M., & Newland, P. (2009). Processing of proprioceptive inputs in the locust: quantitative analysis of the responses of spiking local interneurones in the metathoracic ganglion. Paper presented at Eighth Gottingen Meeting of the German Neuroscience Society, Germany.

Fisher, A. C., Austin, M. J., Milner, R. P., Brown, M. C., Hagan, R. P., Harding, S. P., & Simpson, D. M. (2009). Setting confidence limits to automatically-generated cursor positions: a simple statistical approach. Paper presented at 7th National Meeting of the British Society for Clinical Electrophysiology of Vision, United Kingdom.

Cagy, M., Infantosi, A. F. C., Sa, A. M. F. L., & Simpson, D. M. (2009). Statistical evoked potential detection with number of degrees of freedom estimated from EEG autocorrelation function. Paper presented at World Congress on Medical Physics and Biomedical Engineering, Germany.

Liu, J., Simpson, D. M., & Allen, R. (2009). Tracking the dynamics of cerebral autoregulation response to sudden changes of PaCO2. Paper presented at World Congress on Medical Physics and Biomedical Engineering, Germany.

Dewhurst, O., Simpson, D. M., Allen, R., & Newland, P. (2009). Validating system identification models of the locust's hind leg reflex control loop using walking and sinusoidal inputs. Paper presented at Eighth Gottingen Meeting of the German Neuroscience Society, Germany.

Notley, S. V., Bell, S. L., Simpson, D., & Smith, D. C. (2008). Applying bootstrap techniques to detect differences in auditory evoked potentials: possible use in anaesthesia monitoring. In 4th IET International Conference on Advances in Medical, Signal and Information Processing, 2008. MEDSIP 2008. (pp. 1-4). USA: Institute of Electrical and Electronics Engineers.

Simpson, D. M., & Birch, A. A. (2008). Does "Square Wave Breathing" make measurements of autoregulation more robust?. 2pp. Paper presented at IPEM Meeting Assessment of the Active Cardiovascular System, .

Beda, A., & Simpson, D. M. (2008). Estimating baroreflex sensitivity in individual recordings: predicting errors in estimates from parametric model. 1-4. Paper presented at 5th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO2008), .

Simpson, D., Turk, R., Notley, S. V., Wright, P. A., & Burridge, J. H. (2008). Functional movement in stoke victims and assessment of wrist control. In S. I. Kim, & T. S. Suh (Eds.), World Congress of Medical Physics and Biomedical Engineering 2006. Seoul, Korea: Springer Verlag.

Simpson, D., & Birch, A. (2008). Model-based assessment of cerebral autoregulation. p.52. Paper presented at IPEM Annual Scientific Meeting, .

Simpson, D. M., & Birch, A. A. (2008). Optimizing the assessment of autoregulation from black-box models. In 4th IET International Conference on Advances in Medical, Signal and Information Processing (MEDSIP 2008). (pp. 1-4). USA: Institute of Electrical and Electronics Engineers.

Simpson, D. M., & Birch, A. A. (2008). Quantitative assessment of cerebral blood flow control from spontaneously varying signals. 141 pp. Paper presented at 4th European Congress for Medical and Biomedical Engineering 2008, .

Simpson, D., & Allen, R. (2008). Reflex control of limb movement: a model based investigation in locusts. p.51. Paper presented at IPEM Annual Scientific Meeting, .

Whitehead, E., Simpson, D. M., Darekar, A., & Birch, A. A. (2008). Resting Satte fMRI: New maps from BOLD. Paper presented at 6th Annual Southampton Neuroscience Group (SoNG) Seminar, .

Dewhirst, O., & Simpson, D. M. (2008). Validating a volterra model of the fast extensor tibia motor neuron in the locusts hind leg reflex control loop using physiological input signals. Poster session presented at 6th Southampton Neuroscience Annual Meeting 2008 (SoNG), .

Bell, S. L., Lv, J., Manders, A. J., & Simpson, D. M. (2007). A bootstrap approach to the detection of auditory evoked potentials. In D. Butinar (Ed.), XX IERASG Biennial Symposium: Programme and Book of Abstracts. (pp. 87). Slovenia: Slovene Society for Clinical Neurophysiology of the Slovene Medical Association.

Simpson, D. M. (2007). Assessing cardiovascular control by modelling methods for clinical and physiological research. Paper presented at Workshop on Vital Organ Modelling, .

Simpson, D. M. (2007). Education for biomedical engineering professionals - crossing boundaries between disciplines II. In Proceedings of 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS2007). (pp. p.6730). USA: Institute of Electrical and Electronics Engineers.

Lv, J., Simpson, D. M., & Bell, S. L. (2006). A modified bootstrap test for the detection of evoked responses with artefact rejection. Paper presented at World Congress on Medical Physics and Biomedical Engineering, .

Beda, A., Carvalho, N. F. C., Phillips, D., Giannella-Neto, A., & Simpson, D. (2006). Changes in cardiovascular indexes during a maths test: are we assessing respiration?. Paper presented at Proceedings of IPEM Measurement and Modelling of Autonomic Function, .

Madariaga Estrada, H. G., Simpson, D. M., & Boylan, G. B. (2006). Changes in heart rate associated with neonatal seizures. In Proceedings of Annual Scientific Meeting & IBEX 2006 Exhibition. (pp. 15-16). York, UK: Institute of Physics and Engineering in Medicine.

Botero Rosas, D. A., Infantosi, A. F. C., & Simpson, D. M. (2006). Correlacion entre el EEG y la velocimetria doppler cerebral durante el sueno quieto de recien nacido. 302-305. Proceedings of the 20th Brasilian Biomedical Engineering Congress. XX Congresso Brasileiro de Engenharia Biomédica, CBEB2006, .

Lv, J., Simpson, D. M., & Bell, S. L. (2006). Detection of evoked responses by bootstrap methods: new parameters and ROC analysis. 1-4. Paper presented at MEDSIP 2006, Advances in Medical Signal and Information Processing, .DOI: 10.1049/cp:20060382

Simpson, D. M., Turk, R., Notley, S., Wright, P. A., & Burridge, J. H. (2006). Functional movement in stroke victims and assessment of wrist control. Paper presented at World Congress on Medical Physics and Biomedical Engineering, .

Simpson, D. M. (2006). Improving the assessment of dynamic cerebral autoregulation from spontaneously varying signals. 61-62. Paper presented at 11th Meeting of the European Society of Neurosonology and Cerebral Hemodynamics, .

Simpson, D. M., Turk, R., Notley, S., Wright, P. A., & Burridge, J. H. (2006). Muscle activation in wrist movement of stroke victims and unimpaired subjects. In Proceedings of Annual Scientific Meeting & IBEX 2006 Exhibition. (pp. p.59). York, UK,: Institute of Physics and Engineering in Medicine.

Simpson, D. M., Turk, R., Notley, S. V., & Burridge, J. H. (2006). Muscle activation in wrist movement of stroke victims and unimpaired subjects. Institute of Physics and Engineering in Medicine Annual Scientific Conference, United Kingdom.

Liu, J., Simpson, D. M., & Allen, R. (2006). Tracing the dynamics of the cerebral autoregulation response to step-wise changes in PaCO2. p.40. 8th International Conference on XeXT and related CBF techniques, .

Lv, J., Simpson, D. M., & Bell, S. L. (2005). A statistical approach to measuring hearing thresholds from auditory brainstem responses. Paper presented at International Evoked Response Audiometry Study Group (IERASG), Havana, Cuba, 13-16 June 2005, .

Bravo, F. R. N., Simpson, D. M., Nadal, J., Panerai, R. B., Marinatto, M. N. V., Lopes, J. M. A., & Evans, D. H. (2005). Use of respiratory CO2 signals for the assessment of CO2 reactivity in newborns. Paper presented at IFMBE Proceedings of the 3rd European Medical and Biological Engineering Conference, IFMBE European Conference on Biomedical Engineering, Prague, Czech Republic, 20-25 November 2005, .

Lv, J., Bell, S. L., & Simpson, D. M. (2004). A statistical test for the detection of auditory evoked potentials. Paper presented at IPEM Annual Scientific Meeting, .

Liu, J., Simpson, D. M., & Allen, R. (2004). A suggestion for selecting parameters in the assessment of cerebral autoregulation. Poster session presented at PGBIOMED04: 3rd IEEE EMBSS UK & RI Postgraduate Conference in Biomedical Engineering & Medical Physics, .

Ramos, E. G., Nadal, J., Panerai, R. B., Simpson, D. M., & Evans, D. H. (2004). An automatic selection method for cerebral blood flow autoregulation signals from neonates. Paper presented at Third Latin American Congress on Biomedical Engineering (CLAEB2004), .

Liu, J., Simpson, D. M., Pamerai, R. B., Ramos, E. G., & Allen, R. (2004). Assessment of cerebral autoregulation using a linear filter model: analysis of dispersion. Paper presented at Mediterranean Conference on Medical and Biological Engineering MEDICON, .

Beda, A., Jones, A., Phillips, D., & Simpson, D. M. (2004). Clustering of heart-rate variability responses during a psychological stress test. Poster session presented at PGBIOMED04: EMBSS UKRI Postgraduate Conference on Biomedical Engineering and Medical Physics, .

Simpson, D. M., Liu, J., & Allen, R. (2004). High spontaneous variability in blood pressure helps in assessing blood flow control. Third Latin American Congress on Biomedical Engineering (CLAEB2004), Joao Pessoa, 22-25 September 2004, .DOI: 10.1088/0967-3334/26/5/012

Lv, J., Simpson, D. M., & Bell, S. L. (2004). Objective tests for the detection of auditory evoked potentials. 1-2. Paper presented at 3rd IEEEPGBIOMED04: EMBSS UK & RI Postgraduate Conference in Biomedical Engineering & Medical Physics, .

Simpson, D. M., Allen, R., De Stefano, A., & Lutman, M. E. (2003). Demystifying biomedical signal processing: short courses in biomedical signal processing for health-care professionals. Paper presented at World Congress on Medical Physics and Biomedical Engineering, .

Simpson, D. M., Allen, R., De Stefano, A., & Lutman, M. E. (2003). Demystifying biomedical signals: short courses in biomedical signal processing for health care professionals. In Proceedings of the World Congress on Medical Physics & Biomedical Engineering, Sydney, Australia, 24-29 August 2003. World Congress on Medical Physics & Biomedical Engineering.

Simpson, D. M., Panerai, R. B., Ramos, D. H., Nadal, E. G., & Evans, J. (2003). High variability in the autoregulation index estimated in neonates at rest. Paper presented at IPEM Meeting: Assessment of the Active Cardiovascular System, .

Botero Rosas, D. A., Infantosi, A. F. C., & Simpson, D. M. (2003). Is there an association between spontaneous neurological activity and cerebral blood flow in newborns?. Paper presented at World Congress on Medical Physics and Biomedical Engineerig, .DOI: 10.1088/0031-9155/49/16/E01

Simpson, D. M. (2003). Signal processing and health-care. Paper presented at IEEE EMBS UKRI Postgraduate Conference on Biomedical Engineering and Medical Physics, .

Simpson, D. M., Botero Rosas, D. A., & Infantosi, A. F. C. (2002). Estimation of coherence between cerebral blood flow velocity and EEG activity in newborn babies. 58-59. Paper presented at Annual Scientific Meeting of the Institute of Physics and Engineering in Medicine, .

Simpson, D. M. (2002). Signal analysis for the investigation of brain blood flow control. Paper presented at Royal Academy of Engineering: UK Biomedical Futures, .

Ramos, E. G., Nadal, J., Villar, M. N., Lopes, J. M. A., Simpson, D. M., Panerai, R. B., & Evans, D. H. (2001). Comparação entre técnicas de avaliação da auto-regulação do fluxo sangüíneo cerebral de neonatos. In Proceedings of the II Congreso Latinoamericano de Ingeniería Biomédica. Havana, Cuba: Ángel Regueiro Gómez.

Lopes, J. M. A., Panerai, R. B., Simpson, D. M., Ramos, E. G., Villar, M., Nadal, J., & Evans, D. H. (2001). Does hypoxic ischaemic encephalopathy (HIE) in neonates affect the development of normal cerebral haemodynamics?. Pediatric Academic Societies 2001 Annual Meeting, .

Simpson, D. M., Panerai, R. B., Naylor, A. R., & Evans, D. H. (2001). Impairment of cerebral autoregulation in the first hours after carotid endarterectomy (CEA). 13. Paper presented at Abstracts of the 6th Meeting of the European Society of Neurosonology and Cerebral Haemodynamics, .

Simpson, D. M., Panerai, R. B., Naylor, A. R., & Evans, D. H. (2001). Measurement of cerebral blood flow autoregulation from spontaneous changes in arterial blood pressure. In Proceedings of the sixth Portuguese Conference on Biomedical Engineering. Faro, Portugal: Faculty of Science & Technology, University of Algarve.

Simpson, D. M., Panerai, R. B., Naylor, A. R., & Evans, D. H. (2001). Measurement of cerebral blood flow autoregulation from spontaneous changes in arterial blood pressure. Paper presented at 6th Portuguese Conference on Biomedical Engineering, .

Simpson, D. M., Panerai, R. B., Naylor, A. R., & Evans, D. H. (2001). Parametric modeling of arterial blood pressure and blood flow velocity, for measuring cerebral autoregulation. p.175. Paper presented at Abstracts of IPEM Annual Scientific Meeting, .

Report

Leighton, T. G., Pelphs, A. D., & Simpson, M. D. (1998). Oceanic bubble sizing: measurements and proposed studies. (IVR Technical Report; No. 273). Southampton, GB: University of Southampton.

Title	Module Code	Programme	Role
Audio Signal Processing	ISVR3040	Acoustical Engineering, Acoustics and Music	Coordinator
Audio Signal Processing	ISVR6103	MSc Sound and Vibration Studies	Coordinator
Biomedical Applications of Signal Processing	ISVR6074	MSc Sound and Vibration Studies	Coordinator
Demystifying Biomedical Signals	ISVR6110	Principles and Applications	Coordinator

David Simpson has focussed on cross-disciplinary learning and teaching at the interface between engineering and medicine / life-sciences. Current courses cover signal processing for audio and biomedical applications.

Prof David Simpson
Engineering and the Environment University of Southampton Highfield Southampton SO17 1BJ

Room Number:13/3071

Telephone:(023) 8059 3221
Facsimile:(023) 8059 3190
Email:ds@isvr.soton.ac.uk

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