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Professor Andrew Collins BSc (Hons.), MSc, PhD

Professor of Genetic Epidemiology and Bioinformatics

Professor Andrew Collins is Professor of Genetic Epidemiology and Bioinformatics within Medicine at the University of Southampton.

Professor Collins began his academic career in Southampton in 1989 and was appointed head of the Genetic Epidemiology and Bioinformatics research group in 2002. He has developed diverse research projects spanning non-disjunction and aberrant recombination patterns, bioinformatic prediction of imprinted and disease genes, biological properties of chromosomes, segregation analysis, autozygosity mapping, and linkage mapping studies for various diseases, genome-wide association mapping and next generation sequencing.

He is currently working on the genetic basis of cleft lip and palate, breast cancer and leukemia, along with methodology for analysis of next generation sequencing data and patterns of linkage disequilibrium in human and non-human genomes. Google Scholar:

Qualifications

BSc (Hons.) Zoology, University of Nottingham (1982).
MSc Biological Computation, University of York (1989)
PhD, University of Southampton (1994).

Appointments held

Senior research fellow, Human Genetics, University of Southampton, 1995-1996

Non-clinical lecturer, Human Genetics, University of Southampton,1997-2001

Reader, Human Genetics, University of Southampton, 2001-2005

Research

Responsibilities

Publications

Contact

Research interests

Current research is focused on:

1. The development and application of machine learning methods for the identification of the genetic basis of early onset breast cancer.
2. Development of bioinformatic analyses of next-generation sequencing data and application to cancer genomes.
3. Approaches to meta-analysis to determine the genetic basis of risk and he identification of genetic factors influencing survival in early onset breast cancer.
4. The genetic basis of paediatric inflammatory bowel disease.

Research group

Human Development and Health

Affiliate research group

Human Development and Physiology

Postgraduate student supervision

2003 Sarah Ennis PhD
2004 William Tapper PhD
2007 Winston Lau PhD
2007 Mikkel Christensen PhD
2008 Tai-Yue Kuo PhD
2008 Jane Gibson PhD
2009 Jay Self DM
2010 Victoria Hammond PhD

Current

Ioannis Politopoulos PhD

University of Southampton

Member of Southampton High Performance Computing steering group.
Member of the Institute for Complex Systems Simulation (ICSS) executive board

Associate Editor for the Annals of Human Genetics and the Open Bioinformatics Journal.

Visiting Professorships, University of Sydney, University of Melbourne.

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Articles

Book

Collins, A. R. (Ed.) (2008). Linkage disequilibrium and association mapping: analysis and applications. (Methods in Molecular Biology; Vol. 376). Totowa, USA: Humana. DOI: 10.1007/978-1-59745-389-9

Book Chapters

Collins, A. (Accepted/In press). Linkage analysis and gene mapping. In M. J. Zvelebil, & J. M. Hancock (Eds.), Concise Encyclopaedia of Bioinformatics and Computational Biology 2nd edition Hoboken, US: John Wiley & Sons.
Kuo, T-Y., Lau, W., & Collins, A. R. (2008). LDMAP: the construction of high-resolution linkage disequilibrium maps of the human genome. In A. R. Collins (Ed.), Linkage Disequilibrium and Association Mapping: Analysis and Applications (pp. 47-57). (Methods in Molecular Biology; Vol. 376). Totowa, USA: Humana. DOI: 10.1007/978-1-59745-389-9_4
Collins, A. R. (2008). Linkage disequilibrium and association mapping: an introduction. In A. R. Collins (Ed.), Linkage Disequilibrium and Association Mapping (pp. 1-15). (Methods in Molecular Biology; Vol. 376). Totowa, USA: Humana. DOI: 10.1007/978-1-59745-389-9_1
Collins, A., & Morton, N. (2007). Genome scanning by composite likelihood. In M. Weale (Ed.), Genetic Epidemiology II: Latest Developments (The Biomedical & Life Sciences Collection). London, UK: Henry Stewart Talks.
Morton, N., & Collins, A. (2004). Optimal use of linkage disequilibrium, haplotypes, and integrated maps for positional cloning. In M. Weale (Ed.), Genetic Epidemiology I: Fundamentals, Theory, Practice and Latest Developments (The Biomedical & Life Sciences Collection). London, UK: Henry Stewart Talks.
Collins, A. (2003). Genetics maps: integration. In D. Cooper (Ed.), Nature Encyclopedia of the Human Genome (pp. 888-891). London, UK: Nature Publishing Group.

Conference

Sahota, S., Bryant, D., Weston-Bell, N., Tapper, W., Bolomsky, A., Zojer, N., & Collins, A. (2017). Defining clonal plasticity using whole exome sequencing in single cells in an index case of amp1q21 multiple myeloma. Clinical Lymphoma, Myeloma & Leukemia, 17(1), [e108]. DOI: 10.1016/j.clml.2017.03.196

Letter/Editorial

Bryant, D., Tapper, W., Weston-Bell, N. J., Bolomsky, A., Song, L., Xu, S., ... Sahota, S. S. (2018). Single cell exomes in an index case of amp1q21 multiple myeloma reveals more diverse mutanomes than the whole population. Blood, 132(2), 232-235. DOI: 10.1182/blood-2018-01-829291

Report

Scott, M., Boardman, R. P., Reed, P. A. S., Byatt, D., Stark, I., Cox, S. J., ... Soady, K. A. (2016). Introducing research data - fourth edition. Southampton, GB: University of Southampton.

Review

Collins, A. (2018). The challenge of genome sequence assembly. Open Bioinformatics Journal, 11(1), 231-239. DOI: 10.2174/1875036201811010231

Professor Andrew Collins
Duthie Building (MP 808),
Southampton General Hospital,
Southampton,
SO16 6YD

Room Number: SGH/Duthie/MP808

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