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Professor Andrew R Collins BSc (Hons), MSc, PhD

Professor of Genetic Epidemiology and Bioinformatics

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Andrew Collins is Professor of Genetic Epidemiology and Bioinformatics within Medicine at the University of Southampton.

Professor Collins began his academic career in Southampton in 1989 and was appointed head of the Genetic Epidemiology and Bioinformatics research group in 2002. He has developed diverse research projects spanning non-disjunction and aberrant recombination patterns, bioinformatic prediction of imprinted and disease genes, the biological properties of chromosomes, segregation analysis, autozygosity mapping, and linkage mapping studies for various diseases, genome-wide association mapping and next generation sequencing. Recent research projects include: the development and application of machine learning methods to determine the genetic basis of early onset breast cancer; bioinformatic analyses of next-generation sequencing data and application to cancer genomes; approaches to meta-analysis to identify genetic factors influencing survival in early onset breast cancer and the genetic basis of paediatric inflammatory bowel disease.

Qualifications

BSc (Hons.) Zoology, University of Nottingham (1982)
MSc Biological Computation, University of York (1989)
PhD, University of Southampton (1994)

Appointments held

Senior research fellow, Human Genetics, University of Southampton, 1995-1996
Non-clinical lecturer, Human Genetics, University of Southampton,1997-2001
Reader, Human Genetics, University of Southampton, 2001-2005

Research

Responsibilities

Publications

Teaching

Contact

Research interests

Current research interests include methods for improving the filtering of patient sequence data to identify disease variation, recognition of signatures of natural selection in genomes, genome sequence assembly, ancient DNA, the genetic basis of cleft lip and palate and analysis of patterns of linkage disequilibrium in human and non-human genomes.

PhD supervision

Current PhD students:

Dareen Alyousfi
Clare Horscroft
Alejandra Vergara-Lope

Department(s)

Human Development and Health

Faculty ethics committee member

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Articles

Book

Collins, A. R. (Ed.) (2008). Linkage disequilibrium and association mapping: analysis and applications. (Methods in Molecular Biology; Vol. 376). Humana. https://doi.org/10.1007/978-1-59745-389-9

Book Chapters

Collins, A. (Accepted/In press). Linkage analysis and gene mapping. In M. J. Zvelebil, & J. M. Hancock (Eds.), Concise Encyclopaedia of Bioinformatics and Computational Biology 2nd edition John Wiley & Sons.
Kuo, T-Y., Lau, W., & Collins, A. R. (2008). LDMAP: the construction of high-resolution linkage disequilibrium maps of the human genome. In A. R. Collins (Ed.), Linkage Disequilibrium and Association Mapping: Analysis and Applications (pp. 47-57). (Methods in Molecular Biology; Vol. 376). Humana. https://doi.org/10.1007/978-1-59745-389-9_4
Collins, A. R. (2008). Linkage disequilibrium and association mapping: an introduction. In A. R. Collins (Ed.), Linkage Disequilibrium and Association Mapping (pp. 1-15). (Methods in Molecular Biology; Vol. 376). Humana. https://doi.org/10.1007/978-1-59745-389-9_1
Collins, A., & Morton, N. (2007). Genome scanning by composite likelihood. In M. Weale (Ed.), Genetic Epidemiology II: Latest Developments (The Biomedical & Life Sciences Collection). Henry Stewart Talks.
Morton, N., & Collins, A. (2004). Optimal use of linkage disequilibrium, haplotypes, and integrated maps for positional cloning. In M. Weale (Ed.), Genetic Epidemiology I: Fundamentals, Theory, Practice and Latest Developments (The Biomedical & Life Sciences Collection). Henry Stewart Talks.
Collins, A. (2003). Genetics maps: integration. In D. Cooper (Ed.), Nature Encyclopedia of the Human Genome (pp. 888-891). Nature Publishing Group.

Conferences

Wojdacz, T. K., Amarasinghe, H. E., Rose-Zerilli, M. J. J., Beattie, A., Forster, J., Kadalayil, L., Blakemore, S., Parker, H., Larrayoz, M., Clifford, R., Davis, Z., Else, M., Cohen, D., Steele, A. J., Rosenquist, R., Collins, A., Pettitt, A., Hillmen, P., Plass, C., ... Strefford, J. C. (2018). The clinical importance of DNA methylation signatures in chronic lymphocytic leukemia patients treated with chemo-immunotherapy. Cancer Research, 78(13), [Abstract 3306]. https://doi.org/10.1158/1538-7445.AM2018-3306
Sahota, S., Bryant, D., Weston-Bell, N., Tapper, W., Bolomsky, A., Zojer, N., & Collins, A. (2017). Defining clonal plasticity using whole exome sequencing in single cells in an index case of amp1q21 multiple myeloma. Clinical Lymphoma, Myeloma & Leukemia, 17(1), [e108]. https://doi.org/10.1016/j.clml.2017.03.196

Letter/Editorial

Bryant, D., Tapper, W., Weston-Bell, N. J., Bolomsky, A., Song, L., Xu, S., Collins, A. R., Zojer, N., & Sahota, S. S. (2018). Single cell exomes in an index case of amp1q21 multiple myeloma reveals more diverse mutanomes than the whole population. Blood, 132(2), 232-235. https://doi.org/10.1182/blood-2018-01-829291

Report

Scott, M., Boardman, R. P., Reed, P. A. S., Byatt, D., Stark, I., Cox, S. J., Coles, S. J., Collins, A., Earl, G. P., Jasion, G., Mbuya, T. O., & Soady, K. A. (2016). Introducing research data - fourth edition. University of Southampton.

Review

Collins, A. (2018). The challenge of genome sequence assembly. Open Bioinformatics Journal, 11(1), 231-239. https://doi.org/10.2174/1875036201811010231

Module lead MSc Genomic Medicine

Personal Academic Tutor BM programmes

Professor Andrew R Collins
Faculty of Medicine, Room AB215, Mailpoint 801, South Academic Block, University Hospital Southampton, Tremona Road, Southampton, SO16 6YD

Room Number: SGH/Duthie/MP808

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