The University of Southampton
Medicine
Phone:
(023) 8120 4316
Email:
F.Cagampang@soton.ac.uk

Dr Felino Cagampang BSc, MSc, PhD

Associate Professor in Integrative Physiology

Dr Felino Cagampang's photo
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Dr Felino Cagampang is currently Associate Professor in Integrative Physiology within Medicine at the University of Southampton. He obtained his undergraduate degree at the University of the Philippines, and graduate degrees (MSc & PhD) at Nagoya University (Japan). He did his post-doctoral research work at the Mitsubishi Kasei Institute of Life Sciences (Japan), at King’s College London, and at the University of Manchester, in the field of circadian clock biology. In 2002, he joined the University of Southampton.

We are now in a unique position of offering potential treatments not just for the benefit of the pregnant mother but also for the future health of the offspring

Dr Cagampang’s current research focuses on developmental programming of obesity and the metabolic syndrome, and the role of the biological clock system in disease pathologies and treatment. His work is funded by the Biotechnology and Biological Sciences Research Council (BBSRC), the Medical Research Council (MRC) and Diabetes UK. Dr Cagampang’s research group is based at the Institute of Developmental Sciences (Southampton General Hospital site), and comprises both clinical and basic scientist and researchers, as well as postgraduate and medical students.

Qualifications

BSc, Animal Science, University of the Philippines (1983)
MSc, Animal Science, University of the Philippines (1989)
MSc, Reproductive Physiology, Nagoya University, Japan (1989)
PhD, Reproductive Neuroendocrinology, Nagoya University, Japan (1992)
Postgraduate Certificate, Academic Practice in Higher Education, University of Southampton (2003)

Appointments held

Research Assistant/Instructor, University of the Philippines, 1983-92.

Postdoctoral Research Fellow, Laboratory of Integrative Brain Function, Mitsubishi Kasei Institute of Life Sciences (Japan), 1992-93.

Postdoctoral Research Fellow, School of Biomedical Sciences, King’s College London, 1993-98.

Demonstrator in Neuroanatomy, School of Biomedical Sciences, King’s College London, 1995-98.

Senior Research Fellow, School of Biological Sciences, University of Manchester, 1998-2002.

Lecturer, School of Medicine, University of Southampton, 2002-2009.

Senior Lecturer, Faculty of Medicine, University of Southampton, 2009-14.

Associate Professor, Faculty of Medicine, University of Southampton, 2014-present.

 

 

 

 

 

Research

Responsibilities

Publications

Teaching

Contact

Research interests

Dr Cagampang’s research focuses on developmental programming of obesity and the metabolic syndrome, and the role of the biological clock system in disease pathologies and treatment.

Developmental programming of obesity and the metabolic syndrome

In collaboration with clinical colleagues, Dr Cagampang has developed a unique mouse model where offspring of obese mothers develop a phenotype similar to the human metabolic syndrome (i.e. a clustering of cardiometabolic risk factors that include obesity and having fatty liver, elevated blood pressure, insulin resistance and glucose intolerance, dyslipidemia, being in a proinflammatory and prothrombic state). We found that maternal obesity during pregnancy, as a consequence of too much fat in the mother’s diet, can affect the developing liver of the fetus, making them more susceptible to developing fatty liver in later life. Eating an unhealthy fat-enriched diet in postnatal life can cause the fatty liver condition rapidly progressing to non-alcoholic fatty liver disease with ageing. We are currently investigating various mechanisms that may be involved in the developmental programming of this metabolic disorder, including mitochondrial dysfunction, telomere and epigenetic modifications, and altered circadian clock function. We are also exploring various intervention strategies to protect the offspring from developing metabolic syndrome in adulthood. We have shown previously in this mouse model that by giving the cholesterol lowering drug statin to obese pregnant mothers, it not only improves the mother’s cardiometabolic health but was also able to give some post weaning protection to the offspring fed an unhealthy fat-enriched diet. Currently we are investigating in this mouse model whether improving glycaemic control of the obese pregnant mothers with the anti-diabetic drug metformin will also reduce future risk of the offspring to obesity and the metabolic syndrome.

With colleagues from Clinical Neurosciences, we are exploring the possibility of whether obesity-induced high fat feeding during pregnancy increase susceptibility of the offspring to Alzheimer disease and eye damage with ageing. In collaboration with clinical colleagues in Obstetrics & Gynaecology, we are examining follicular development in the ovaries of female offspring from the high-fat fed mothers. Other collaborative work using this mouse model includes the investigation of placental function in obese pregnancy, and muscle function, bone development, brown adipose tissue function and thermogenesis, and changes in gut microflora and physiology in offspring from these obese mothers.

Circadian clock system and developmental programming of diseases

Most physiological processes exhibit rhythmic changes with a period of around 24h (termed 'circadian'), and are regulated within cells by endogenous timing systems involving a set of 'clock' genes. The involvement of the circadian clock system in the pathogenesis of diseases remains unclear. Dr Cagampang is interested in the role of the clock system in developmental programming of the metabolic syndrome. Using the mouse model of maternal high fat feeding leading to metabolic syndrome susceptibility in the offspring, Dr Cagampang’s group has been investigating whether there are alterations in circadian rhythms of genes involved in regulating appetite, energy expenditure and clock function in various tissues and organs of the offspring. His group is examining whether these changes are brought about by epigenetic modifications. In collaboration with clinical colleagues from Obstetrics & Gynaecology, Dr Cagampang is also investigating sleep and clock function in gynaecological pathologies.

 

 

Academic unit(s)

Human Development and Health Academic Units

Affiliate academic unit(s)

Human development and physiology Research group

Postgraduate supervision

PhD supervision (completed)

Dyan Sellayah PhD 2009
Sanjay Asopa PhD 2010
Maqsood Elahi PhD 2011

MPhil/PhD students currently supervised

Kerry Hyde
Khaled Sadek
Linden Stocker
Hugh Thomas
Aisha Rasool
Oliver Harrison

Responsibilities within the Faculty of Medicine

Deputy Coordinator, BMedSc Project Group
BMedSc Project Coordinator, HDH Academic Unit
Member, BMedSc Curriculum and Assessment Group
Member, BM Year 4 Steering Group
Home Office Project Licence Holder

National and International Responsibilities

MSc Examiner: National University of Ireland 2012
Member of the Editorial Board: Journal of Developmental Origins of Health and Disease
Referee for several international journals: Biology of Reproduction, Brain Research, British Journal of Nutrition, British Journal of Obstetrics and Gynaecology, Clinical Science, Endocrinology, Journal of Endocrinology, Journal of Neuroendocrinology, Journal of Molecular Endocrinology, Journal of Physiology, Journal of Developmental Origins of Health and Disease, Neuroscience Letters, Neuroscience, Nutrients, Nutrition Research, PLOS One, Reproduction, Trends in Endocrinology and Metabolism
Grant reviewer: Biotechnology and Biological Sciences Research Council (UK), Medical Research Council (UK), Diabetes UK, British Heart Foundation, Wellcome Trust (UK), French National Research Agency
Member: International Society for Developmental Origins of Health and Adult Disease, Physiological Society (UK), British Neuroscience Association, British Society for Neuroendocrinology, Philippine Society for Neuroscience (founding member)

 

 

Articles

Book Chapter

 

Graduate Group Facilitator on the BM4 programme. Facilitate group discussion on clinical topics.

Lectures on various topics on the BIOL3044 and BIOL6044 course (Maternal, Fetal and Neonatal Physiology). Delivers lectures on developmental programming of reproduction, metabolism and brain function.

BMedSc project supervisor. Supervise laboratory based research projects of medical students.

Postgraduate supervisor. Supervise research work of MPhil, DM and PhD students.

Personal Tutor. Provide support and guidance to BM4, BM5 and BM6 medical students in their academic and personal development

Deputy Coordinator. BMedSc Project (BM5 Programme)

 

 

Dr Felino Cagampang
Institute of Developmental Sciences
University of Southampton Faculty of Medicine
Southampton General Hospital (mailpoint 887)
Southampton SO16 6YD
UK

tel: 023 8120 4316
fax: 023 8120 4221
email: f.cagampang@soton.ac.uk

Room Number:SGH/IDS-DSB07

Telephone:(023) 8120 4316
Facsimile:(023) 8078 5255
Email:F.Cagampang@soton.ac.uk

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