The University of Southampton
Medicine

Dr Rahul Tare MSc, PhD

Lecturer - Musculoskeletal Science and Bioengineering

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Dr Rahul Tare is Lecturer - Musculoskeletal Science and Bioengineering within the Faculties of Medicine & Engineering and the Environment at the University of Southampton.

My research harnesses a multidisciplinary approach encompassing human stem cells, primary skeletal cells, tissue engineering and acoustofluidics to generate 3-D cartilage grafts, and seeks to gain insight into the development of skeletal diseases through improved appreciation of the molecular regulation of skeletogenesis

Rahul leads an interdisciplinary research group based in the Centre for Human Development, Stem Cells and Regeneration. His research focuses on human stem cells, tissue engineering and skeletal development.

Potential students and researchers interested in the above mentioned areas of research are encouraged to contact Rahul.

Qualifications

PhD, University of Southampton, UK (2002)
Postgraduate Certificate in Academic Practice, University of Southampton, UK (2013)

Appointments held

Lecturer, Faculties of Medicine and Engineering & the Environment, University of Southampton (May 2010 onwards)

Senior Postdoctoral Career Track Fellow, Bone and Joint Research Group, University of Southampton (Jan 2009 – Apr 2010)

Postdoctoral Career Track Fellow, Bone and Joint Research Group, University of Southampton (July 2008 – Dec 2008)

Postdoctoral Research Fellow, Bone and Joint Research Group, University of Southampton (Mar 2004 – June 2008)

Postdoctoral Research Fellow, Department of Cell Biology, University of Massachusetts Medical School, Worcester, USA (Oct 2002 – Feb 2004)

Research

Responsibilities

Publications

Teaching

Contact

Research interests

Rahul’s research group utilises innovative approaches encompassing human stem cells, primary skeletal cell populations, tissue engineering and acoustofluidics to generate 3-D cartilage grafts for the regeneration of articular cartilage defects, and seeks to gain insight into the development of skeletal diseases such as osteoporosis and osteoarthritis through improved appreciation of the molecular regulation of skeletal development.

Research projects
  1. Isolation and characterisation of human progenitor/stem cell populations from bone marrow and articular cartilage.
  2. Development of an acoustofluidic bioreactor platform for cartilage tissue engineering.
  3. Generation of human embryonic stem cell-derived chondrocytes for bioengineering cartilage.
  4. Analysis of the effects of the deletion of the Bag-1 (Bcl-2-associated athanogene-1) gene on skeletal development.
  5. Elucidation of the interaction between the molecular chaperone (HSC-70) and cochaperone (BAG-1) proteins in the regulation of skeletal stem cell osteogenic differentiation and maintenance of the articular chondrocyte phenotype.
Collaborators

Faculty of Engineering and the Environment – Prof Martyn Hill, Dr Peter Glynne-Jones, Dr Bram Sengers, Dr Martin Stolz, Dr Xunli Zhang, Dr Richard Cook

Faculty of Medicine – Prof Richard Oreffo, Prof Graham Packham, Dr Franchesca Houghton, Mr Ramsey Cutress

External – Prof Kenneth Ka Ho Lee (Chinese University of Hong Kong), Prof Paul Townsend (University of Manchester), Prof Andrew Zannettino (University of Adelaide)

Funding

European Calcified Tissue Society, Wessex Medical Research, Rosetrees Trust, Research Grants Council of Hong Kong, Arthritis Research UK, EPSRC, University of Southampton PhD scholarships

Primary research group: Bone and Joint Diseases, Bioengineering Science

 

Micromass cultures
Figure 1
Cartilage explants
Figure 2
MSCs from human BM
Figure 3

Academic unit(s)

Human Development and Health Academic Units

Affiliate academic unit(s)

Human development and physiology Research group

1. Primary PhD supervisor

Current:

Howard Tribe (2016)
Lauren Jevons (2015)

Past (successfully completed):

Umesh Jonnalagadda (2013-2016)
Joanna Greenhough (2011-2014)
Siwei Li (2010-2013)

2. Second/third PhD supervisor

Current:

Juan Aviles Milan
Michael Glinka
Alia Hafiz
Sussane Renz
Catarina Moura
Daniel Tang
Shona Waddell

Past (successfully completed):

Elizabeth Lemm
Agnieszka Janeczek
Sam Dias

3. Personal tutor for BM and PG students in FoM

4. Representative for the Bone and Joint theme at the BM5 Year II poster presentation sessions

5. Member of University Senate (2013-16)

6. Member of HDH Academic Unit Operations Group

7. Member of PCAP Mentors Group

External responsibilities

  1. Manuscript reviewer for peer-reviewed journals – Apoptosis, Journal of Tissue Engineering and Regenerative Medicine, Experimental Cell Research, Tissue Engineering, Stem Cell Research, Journal of Functional Biomaterials, Connective Tissue Research, Journal of Tissue Engineering, Scientific Reports, Biomaterials, PLoS One

  2. Grant reviewer for BBSRC, MRC, Arthritis Research UK, Swiss National Science Foundation, Orthopaedic Research UK, Action Research UK, Croucher Foundation (Hong Kong)

Articles

Book Chapters

1. BM5 programme
a. Year I

i. Lectures:

Basic bone and cartilage biology
Calcium homeostasis

ii. Prepare OBA and EMI questions on above topics

b. Year IV

i. Lectures:
Basic bone and cartilage biology (refresher session)
Metabolic bone diseases

c. Research project supervision

i.  Supervise BM Year III and MMedSc research project students
ii. Mark project reports and mark student presentations

2. BM4 programme

i.   Lecture: Calcium homeostasis (Year II)
ii.  Prepare OBA and EMI questions on above topic
iii. Facilitation (Year I)

3. MRes in Stem Cells, Development and Regenerative Medicine – Deputy Director
a. Stem Cell module

i.  Lecture: Skeletal Stem Cells
ii. Journal clubs:
    Pluripotent stem cells 
    Musculoskeletal stem cells
    Mark journal club reports

b. Lead for Research Project 1 module

i.   Allocate research projects
ii.  Supervise research project students
iii. Mark research projects, marking moderator
iv. Organise and conduct vivas
v.  Organise oral presentations

c.  Lead for Advanced Scientific Skills module

i.  Mark scientific and lay abstracts
ii. Organise lay oral presentations

d. Research Project 2 module

i.   Supervise research project students
ii.  Mark research projects
iii. Conduct vivas
v.  Organise and mark poster presentations

e. Research Skills in Biomedical Sciences module

i. Mark research proposals

4. MSc Diabetes Best Practice
a. Foundations module

i.   Mark group presentations
ii.  Mark individual oral presentations
iii. Lecture: Reflective Learning
iv. Mark reports on Key Event Reflection

5. Faculty of Medicine PGR student induction programme

a. Lectures:
(i)  Role of epigenetics in regulation of gene expression
(ii) PCR and Real-time qPCR

6. BEng Mechanical Engineering (Faculty of Engineering and the Environment)

a. Lectures:
(i) Tissue engineering (as part of the Functional Materials in Orthopaedics lecture)
(ii) Biomaterials

b. Supervise IP (individual project) and GDP (group design project) students, mark project reports and poster presentations

7. MSc Biomedical Engineering

a. Lecture: Stem Cells
b. Supervise research project students, mark project reports and poster presentations

Dr Rahul Tare
Centre for Human Development, Stem Cells and Regeneration
Institute of Developmental Sciences
Room: DS D09, Mailpoint: 887
University Hospital Southampton
Tremona Road
Southampton SO16 6YD
United Kingdom
Telephone: +44 (0)23 8120 5257
Email: R.Tare@soton.ac.uk

Room Number:SGH/DS D09/MP887

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