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Research project

Dr H M Haitchi ADAM33 gene and environmental interactions in developing lungs and their involvement in the early life origin of asthma

Staff

Lead researcher

Dr Hans Michael Haitchi MD, MMed(INT), PhD, PD, MRCP(London), FHEA, PGcert

Associate Professor

Research interests

  • Study of the asthma susceptibility gene A Disintegrin and Metalloprotease 33 (ADAM33) in early life and adult asthma and other chronic lung diseases.
  • Development of novel Anti-ADAM33 agents as potential disease modifying asthma therapy.
  • Multiomic study of the influence of the maternal environment (e.g. allergic asthma, obesity) during pregnancy on ADAM33 and other mediators and the early origin of lung disease in the Maternal Environment in Pregnancy (MEP) cohort.

Research outputs

A disintegrin and metalloprotease (ADAM) 33 protein in patients with pulmonary sarcoidosis
Asif Shaffiq,
Hans Michael Haitchi,
Yun Yung Pang,
Abdullah A. Alangari,
Mark G. Jones,
Ben G. Marshall,
Peter H. Howarth,
Donna E. Davies,
& Katherine M.A. O'Reilly
, 2012 , Respirology , 17 (2) , 342--349
DOI: 10.1111/j.1440-1843.2011.02098.x
Type: article
Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation
Yutaka Maeda,
Gang Chen,
Yan Xu,
Hans Michael Haitchi,
Lingling Du,
Angela R. Keiser,
Peter H. Howarth,
Donna E. Davies,
Stephen T. Holgate,
& Jeffrey A. Whitsett
, 2011 , American Journal of Respiratory and Critical Care Medicine , 184 (4) , 421--429
DOI: 10.1164/rccm.201101-0106OC
Type: article
Kruppel-like factor 5 is required for formation and differentiation of the bladder urothelium
Sheila M. Bell,
Liqian Zhang,
Angela Mendell,
Yan Xu,
Hans Michael Haitchi,
James L. Lessard,
& Jeffrey A. Whitsett
, 2011 , Developmental Biology , 358 (1) , 79--90
DOI: 10.1016/j.ydbio.2011.07.020
Type: article
Intersections between pulmonary development and disease
Jeffrey A. Whitsett,
Hans Michael Haitchi,
& Yutaka Maeda
, 2011 , American Journal of Respiratory and Critical Care Medicine , 184 (4) , 401--406
DOI: 10.1164/rccm.201103-0495PP
Type: article