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Research project

Prof S. Gadola: Structure-Activity relationships for CD1c-lipid binding BB/J017302/1

Staff

Other researchers

Professor Chris Skylaris

Professor of Computational Chemistry

Research interests

  • the computational study of chemical processes, especially in problems involving nanostructures and biological molecules. 

Professor Jonathan Essex

Professor

Collaborating research institutes, centres and groups

Computational Systems Chemistry

Our research covers a broad range of domains from nanoscale materials properties, atmospheric chemistry, through to biological systems.

Research outputs

Recent advances in Major Histocompatibility Complex (MHC) class I antigen presentation: plastic MHC molecules and TAPBPR-mediated quality control
Andrew van Hateren,
Timothy Elliott,
& Alistair Bailey
, 2017 , F1000 Research , 6 (158)
DOI: 10.12688/f1000research.10474.1
Type: review
The clonal iNKT cell repertoire in people with type 1 diabetes is characterized by a loss of clones expressing high-affinity T cell receptors
Anna S. Tocheva,
Salah Mansour,
Tristan G.H. Holt,
Samuel Jones,
Andrew Chancellor,
Joseph P. Sanderson,
Efrem Eren,
Timothy Elliott,
Richard Holt,
& Stephan Gadola
, 2017 , The Journal of Immunology , 198 (4) , 1452--1459
DOI: 10.4049/jimmunol.1600255
Type: article
CD1b-restricted GEM T cell responses are modulated by Mycobacterium tuberculosis mycolic acid meromycolate chains
Andrew Chancellor,
Anna Tocheva,
Christopher Cave-Ayland,
Liku Bekele Tezera,
Andrew White,
Juma'a Al Dulayymi,
John Bridgeman,
Ivo Tews,
Susan Wilson,
Nikolai Lissin,
Marc Tebruegge,
Benjamin Marshall,
Sally Sharpe,
Timothy Elliott,
Chris-Kriton Skylaris,
Jonathan W. Essex,
Mark Baird,
Stephan D. Gadola,
Paul Elkington,
& Salah Mansour
, 2017 , Proceedings of the National Academy of Sciences , 114 (51) , E10956--E10964
DOI: 10.1073/pnas.1708252114
Type: article
Cholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cells
Salah Mansour,
Anna Tocheva,
Chris Cave-Ayland,
Moritz M. Machelett,
Barbara Sander,
Nikolai M. Lissin,
Peter E. Molloy,
Mark S. Baird,
Gunthard Stubs,
Nicolas W.J. Schroder,
Ralf R. Schumann,
Jorg Rademann,
Anthony D. Postle,
Bent K. Jakobsen,
Ben G. Marshall,
Rajendra Gosain,
Paul Elkington,
Tim Elliott,
Chris-Kriton Skylaris,
Jonathan W. Essex,
Ivo Tews,
& Stephan D. Gadola
, 2016 , Proceedings of the National Academy of Sciences , 113 (9) , E1266--E1275
DOI: 10.1073/pnas.1519246113
Type: article
Structural and functional changes of the invariant NKT clonal repertoire in early rheumatoid arthritis.
Salah Mansour,
Anna S. Tocheva,
Joseph P. Sanderson,
Lyndsey M. Goulston,
Helen Platten,
Lina Serhal,
Camille Parsons,
Mark H. Edwards,
Christopher H. Woelk,
Paul T. Elkington,
Tim Elliott,
Cyrus Cooper,
Christopher J. Edwards,
& Stephan D. Gadola
, 2015 , The Journal of Immunology , 195 (12) , 5582--5591
DOI: 10.4049/jimmunol.1501092
Type: article
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