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The University of Southampton
Computationally Intensive Imaging
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Dr Xize Niu PhD

Associate Professor

Dr Xize Niu's photo

Dr Xize Niu is Associate Professor within Engineering and Physical Sciences at the University of Southampton.

Xize’s group is currently focused on scientific and engineering challenges in developing wearable/portable chemical sensors for healthcare and environmental monitoring, especially for real time and continuous detection of chemical variations in body or environmental fluids. The key research areas related are microfluidics, lab-on-a-chip, analytical chemistry and mechatronics.

There are openings in his group for postdoctoral research and PhD studies. Applications are welcome.

Research interests

Dr. Xize Niu is interested in engineering microfluidic devices for bioanalytical applications, such as handling tiny amount of liquid samples, and performing high throughput analysis for disease monitoring and diagnostics. Consequently his research covers:

  • Microfluidics and lab-on-a-chip;
  • MEMS, micro and nano technology;
  • Drug screening, biosensors and microdialysis;
  • Protein separation and identification, DNA sequencing;
  • Fluid mechanics, chaotic mixing; Multiphase phase flows and droplets.

He likes to cover a project from the fundamental science through to application and product. He has applied 5 patents and a few of his inventions have been commercialised.

Group members

Dr. Adrian Nightingale (Research Fellow)
Dr. Leong, Chi Leng (Research Fellow)
Dr. Sammer-Ul Hassan (Research Fellow)
Dr. Sharon Coleman (Technical Officer)
Gareth Evans (PhD student)
Juan Avilés (PhD student)
Yu Zhang (PhD student)
Peixiang Xu (MSc student)
Ke Du (MSc student)
Yang Li (MSc student)
Jason Norman (Internship student)

Dr Xize Niu's research
Dr Xize Niu's research

Research group

Mechatronics Engineering Group

Affiliate research group

Bioengineering Science

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FEEG1004-29853-13-14: 13-14-Electrical and Electronics Systems-29853
SESM6021-28551-13-14: 13-14-Introduction to Energy Technologies-28551
FEEG2004 Electronic, Drives and Control

Droplet Microfluidics

Droplets are defined here as water droplets dispersed in an immiscible oil phase or oil droplets dispersed in water. These droplets are contained and motivated through microfluidic conduits having dimensions most easily measured in microns. Droplets microfluidics is emerging as a reliable engineering tool for performing biological operations such as analyte encapsulation, sampling, metering, dilution, reaction, separation and detection.

In Niu’s lab, we are interested in studying droplet generation-on-demand. These studies have led to several publications and two patents, one for robotic droplet generation for lab usages that has been commercialised (DropixTM), and the latest one for sampling droplets from real environments such as body or environmental fluids, which has the potential to be developed into various healthcare and diagnostic devices or environmental sensors.

We are also interested in analysing biochemical molecules with droplet interfaced electrophoresis separation, liquid chromatography and mass spectrometry, or sensitive assays within droplets. For example we have recently developed droplet interfaced parallel separations that can incorporate hundreds of droplets and separation channels onto a single chip, enhancing analytical throughput and reducing sample consumption.

Novel droplet operation units and toolkit are also within our research interests. We have developed microfluidic chips for droplet merging, dilution and sorting etc. (and some of the chips have been commercialised).

High throughput separation of biomolecules
Separation of biomolecules
Droplet on demand
Droplet on demand
Droplet trapping and merging
Droplet trapping and merging
Droplet dilution
Droplet dilution
Dr Xize Niu
Building 27, Room 2029, University of Southampton Highfield Southampton SO17 1BJ

Room Number: 7/5013

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