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A robust and versatile mass spectrometry platform for comprehensive assessment of the thiol redox metabolome.
Redox Biology,
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10.1016/j.redox.2018.02.012 Cortese-Krott, M. M., Mergia, E., Kramer, C. M., Luckstadt, W., Yang, J., Wolff, G., ... Kelm, M. (2018).
Identification of a soluble guanylate cyclase in RBCs: preserved activity in patients with coronary artery disease.
Redox Biology,
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Metabolism of hydrogen sulfide (H2S) and production of Reactive Sulfur Species (RSS) by superoxide dismutase.
Redox Biology,
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Ammonium tetrathiomolybdate following ischemia/reperfusion injury: chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models.
PLoS Medicine,
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Cephalosporin-3’ -diazeniumdiolate NO-donor prodrug PYRRO-C3D enhances azithromycin susceptibility of Non-typeable Haemophilus influenzae biofilms.
Antimicrobial Agents and Chemotherapy,
61(2), e02086-16. DOI:
10.1128/AAC.02086-16Allan, R., Kelso, M. J., Rineh, A., Yepuri, N. R.
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Cephalosporin-NO-donor prodrug PYRRO-C3D shows β-lactam-mediated activity against Streptococcus pneumoniae biofilms.
Nitric Oxide. DOI:
10.1016/j.niox.2017.02.006 Luks, A. M., Levett, D., Martin, D. S., Goss, C.
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Changes in acute pulmonary vascular responsiveness to hypoxia during a progressive ascent to high altitude (5,300 m).
Experimental Physiology,
102(6), 711-724. DOI:
10.1113/EP086083Akaike, T., Ida, T., Wei, F., Nishida, M., Kumagai, Y., Alam, M. M., ... Motohashi, H. (2017).
Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics.
Nature Communications,
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10.1038/s41467-017-01311-yWandrag, L., Siervo, M., Riley, H., Khosravid, . M.
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Does hypoxia play a role in the development of sarcopenia in humans? Mechanistic insights from the Caudwell Xtreme Everest Expedition.
Redox Biology,
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10.1016/j.redox.2017.05.004Ormerod, J. O. M., Evans, J. D. W., Contractor, H., Beretta, M., Arif, S.
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Human second window pre-conditioning and post-conditioning by nitrite is influenced by a common polymorphism in mitochondrial aldehyde dehydrogenase.
JACC. Basic to translational science,
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Hydrogen sulfide attenuates calcification of vascular smooth muscle cells via KEAP1/NRF2/NQO1 activation.
Atherosclerosis,
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10.1016/j.atherosclerosis.2017.08.012Schwarz, K., Singh, S., Parasuraman, S., Rudd, A., Shepstone, L.
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Inorganic nitrate in angina study: A randomized double-blind placebo-controlled trial.
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10.1161/JAHA.117.006478Kayacelebi, A. A., Minović, I., Hanff, E., Frenay, A-R. S., de Borst, M. H.
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Low plasma homoarginine concentration is associated with high rates of all-cause mortality in renal transplant recipients.
Amino Acids,
49(7), 1193-1202. DOI:
10.1007/s00726-017-2420-7Howlin, R. P., Cathie, K., Hall-Stoodley, L., Cornelius, V.
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Low-dose nitric oxide as targeted anti-biofilm adjunctive therapy to treat chronic Pseudomonas aeruginosa infection in cystic fibrosis.
Molecular Therapy,
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10.1016/j.ymthe.2017.06.021 Horscroft, J. A., Kotwica, A. O., Laner, V., West, J. A., Hennis, P. J., Levett, D. Z. H., ... Murray, A. J. (2017).
Metabolic basis to Sherpa altitude adaption.
Proceedings of the National Academy of Sciences. DOI:
10.1073/pnas.1700527114Fleury, N.
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Sub-erythemal ultraviolet radiation reduces metabolic dysfunction in already overweight mice.
Journal of Endocrinology,
233(1), 81-92. DOI:
10.1530/JOE-16-0616Lee, E. S., Boldo, L. S.
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Suppression of TAK1 pathway by shear stress counteracts the inflammatory endothelial cell phenotype induced by oxidative stress and TGF-β1.
Scientific Reports,
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10.1038/srep42487Cortese-Krott, M. M., Koning, A., Kuhnle, G. G., Nagy, P., Bianco, C., Pasch, A.
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The reactive species interactome: Evolutionary emergence, biological significance, and opportunities for redox metabolomics and personalized medicine.
Antioxidants & Redox Signaling. DOI:
10.1089/ars.2017.7083Gilbert-Kawai, E., Coppel, J., Bountziouka, V., Ince, C., Martin, D.
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A comparison of the quality of image acquisition between the incident dark field and sidestream dark field video-microscopes.
BMC Medical Imaging, 1-5. DOI:
10.1186/s12880-015-0078-8Schwarz, K., Singh, S., Parasuraman, S., Bruce, M., Shepstone, L.
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A randomized double-blind placebo controlled crossover trial of sodium nitrate in patients with stable angina INAS.
Future Cardiology,
12(6), 617-626. DOI:
10.2217/fca-2016-0026McIlvenna, L., Monaghan, C., Liddle, L.
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Beetroot juice versus chard gel: a pharmacokinetic and pharmacodynamic comparison of nitrate bioavailability. Nitric Oxide, 1-7. DOI:
10.1016/j.niox.2016.12.006Hennis, P. J., Mitchell, K., Gilbert-Kawai, E., Bountziouka, V., Wade, A.
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Effects of dietary nitrate supplementation on symptoms of acute mountain sickness and basic physiological responses in a group of male adolescents during ascent to Mount Everest Base Camp.
Nitric Oxide,
60, 24-31. DOI:
10.1016/j.niox.2016.08.007Heikal, L., Ghezzi, P., Mengozzi, M.
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Erythropoietin and a nonerythropoietic peptide analog promote aortic endothelial cell repair under hypoxic conditions: role of nitric oxide.
Hypoxia,
4, 121-133. DOI:
10.2147/HP.S104377Muenster, S., Beloiartsev, A., Yu, B., Du, E., Abidi, S., Dao, M., ... Zapol, W. M. (2016).
Exposure of stored packed erythrocytes to NO prevents transfusion-associated pulmonary hypertension.
Anesthesiology, 1-12. DOI:
10.1097/ALN.0000000000001294van der Graaf, A. M., Paauw, N. D., Toering, T. J.
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Impaired sodium-dependent adaptation of arterial stiffness in formerly preeclamptic women: the RETAP-vascular study.
American Journal of Physiology: Heart and Circulatory Physiology,
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10.1152/ajpheart.00010.2016Roberts, L., Ashmore, T., McNally, B., Murfitt, S.
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Inorganic nitrate mimics exercise-stimulated muscular fiber-type switching and myokine and GABA release.
Diabetes, 1-42. DOI:
10.2337/db16-0843Allan, R. N., Morgan, S., Brito-Mutunayagam, S.
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Low concentrations of nitric oxide modulate Streptococcus pneumoniae biofilm metabolism and antibiotic tolerance.
Antimicrobial Agents and Chemotherapy,
60(4), 2456-2466. DOI:
10.1128/AAC.02432-15 Frenay, A-R. S., de Borst, M. H., Bachtler, M., Tschopp, N., Keyzer, C. A., van den Berg, E., ... van Goor, H. (2016).
Serum free sulfhydryl status is associated with patient and graft survival in renal transplant recipients.
Free Radical Biology and Medicine,
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Serum free thiols in chronic heart failure.
Pharmacological Research,
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The fate of sulfate in chronic heart failure.
American Journal of Physiology: Heart and Circulatory Physiology, 1-28. DOI:
10.1152/ajpheart.00645.2016Gorman, S., Lucas, R., Allen-Hall, A., Fleury, N.
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Ultraviolet radiation, vitamin D and the development of obesity, metabolic syndrome and type-2 diabetes. Photochemical & Photobiological Sciences, 1-12. DOI:
10.1039/C6PP00274ARoggenbuck, M., Anderson, D., Barfod, K. K.
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Vitamin D and allergic airway disease shape the murine lung microbiome in a sex-specific manner.
Respiratory Research,
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10.1186/s12931-016-0435-3Curtis, K. J., O'Brien, K. A., Tanner, R. J., Polkey, J. I.
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Acute dietary nitrate supplementation and exercise performance in COPD: a double-blind, placebo-controlled, randomised controlled pilot study.
PLoS ONE,
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Can skin exposure to sunlight prevent liver inflammation? Nutrients,
7(5), 3219-3239. DOI:
10.3390/nu7053219Gilbert-Kawai, E., Sheperdigian, A., Adams, T., Mitchell, K.
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Design and conduct of Xtreme Everest 2: an observational cohort study of Sherpa and lowlander responses to graduated hypobaric hypoxia.
F1000 Research,
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DL-propargylglycine reduces blood pressure and renal injury but increases kidney weight in angiotensin-II infused rats.
Nitric Oxide,
49, 56-66. DOI:
10.1016/j.niox.2015.07.001Wythe, S., Davies, T., Martin, D.
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Getting the most from venous occlusion plethysmography: proposed methods for the analysis of data with a rest/exercise protocol.
Extreme Physiology & Medicine,
4, 8. DOI:
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Inhaled nitric oxide as an adjunctive treatment for cerebral malaria in children: a phase II randomized open-label clinical trial.
Open Forum Infectious Diseases,
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10.1093/ofid/ofv111Cortese-Krott, M., Kuhnle, G.
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Key bioactive reaction products of the NO/H2S interaction are S/N-hybrid species, polysulfides, and nitroxyl.
Proceedings of the National Academy of Sciences, 1-10. DOI:
10.1073/pnas.1509277112Ashmore, T., Roberts, L. D., Morash, A. J., Kotwica, A. O., Finnerty, J., West, J. A., ... Murray, A. J. (2015).
Nitrate enhances skeletal muscle fatty acid oxidation via a nitric oxide-cGMP-PPAR-mediated mechanism.
BMC Biology,
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10.1186/s12915-015-0221-6Frenay, A-R. S., van den Berg, E., de Borst, M. H., Beckmann, B., Tsikas, D.
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Plasma ADMA associates with all-cause mortality in renal transplant recipients.
Amino Acids, 1-9. DOI:
10.1007/s00726-015-2023-0Arif, S., Borgognone, A., Lin, E. L-S., O'Sullivan, A. G., Sharma, V., Drury, N. E., ... Madhani, M. (2015).
Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans.
British Journal of Pharmacology,
172, 3341-3352. DOI:
10.1111/bph.13122Ormerod, J. O. M., Arif, S., Mukadam, M., Evans, J. D. W., Beadle, R., Fernandez, B. O., ... Frenneaux, M. P. (2015).
Short-term intravenous sodium nitrite infusion improves cardiac and pulmonary hemodynamics in heart failure patients.
Circulation: Heart failure,
8(3), 565-571. DOI:
10.1161/CIRCHEARTFAILURE.114.001716Berra, L., Pinciroli, R., Stowell, C. P., Wang, L., Yu, B., Fernandez, B. O., ... Zapol, W. M. (2014).
Autologous tansfusion of stored red blood cells increases pulmonary artery pressure.
American Journal of Respiratory and Critical Care Medicine,
190(7), 800-807. DOI:
10.1164/rccm.201405-0850OCAshmore, T.
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Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart.
The Journal of Physiology, 1-17. DOI:
10.1113/jphysiol.2014.275263Siervo, M., Riley, H. L.
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Effects of prolonged exposure to hypobaric hypoxia on oxidative stress, inflammation and gluco-insular regulation: the not-so-sweet price for good regulation. PLoS ONE,
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Inorganic nitrate promotes the browning of white adipose tissue through the nitrate-nitrite-nitric oxide pathway.
Diabetes. DOI:
10.2337/db14-0496Siddiqi, N., Neil, C., Bruce, M., Maclennan, G., Cotton, S., Papadopoulou, S., ... Frenneaux, M. (2014).
Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI).
European Heart Journal, 1-9. DOI:
10.1093/eurheartj/ehu096Cortese-Krott, M. M.
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Nitrosopersulfide (SSNO-) accounts for sustained NO bioactivity of S-nitrosothiols following reaction with sulfide.
Redox Biology,
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10.1016/j.redox.2013.12.031Cortese-Krott, M. M.
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On the chemical biology of the nitrite/sulfide interaction.
Nitric Oxide,
46, 14-24. DOI:
10.1016/j.niox.2014.12.009Bailey, J. C.
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Pharmacology and therapeutic role of inorganic nitrite and nitrate in vasodilatation. Pharmacology & Therapeutics,
144, 303-320. DOI:
10.1016/j.pharmthera.2014.06.009Umbrello, M., Dyson, A., Bollen Pinto, B.
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Short-term hypoxic vasodilation in vivo is mediated by bioactive nitric oxide metabolites, rather than free nitric oxide derived from haemoglobin-mediated nitrite reduction.
The Journal of Physiology,
592(5), 1061-1075. DOI:
10.1113/jphysiol.2014.255687Ashmore, T.
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Suppression of erythropoiesis by dietary nitrate.
The FASEB Journal,
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The reaction products of sulfide and S-nitrosoglutathione are potent vasorelaxants.
Nitric Oxide,
46, 123-130. DOI:
10.1016/j.niox.2014.12.008Geldenhuys, S., Hart, P. H., Endersby, R., Jacoby, P.
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Ultraviolet radiation suppresses obesity and symptoms of metabolic syndrome independently of vitamin d in mice fed a high-fat diet. Diabetes,
63(11), 3759-3769. DOI:
10.2337/db13-1675Liu, D.
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UVA irradiation of human skin vasodilates arterial vasculature and lowers blood pressure independently of nitric oxide synthase.
Journal of Investigative Dermatology, 1-38. DOI:
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A multi-level analytical approach for detection and visualization of intracellular NO production and nitrosation events using diaminofluoresceins.
Free Radical Biology and Medicine,
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10.1016/j.freeradbiomed.2012.09.008Martin, D. S., Gilbert-Kawai, E. T., Meale, P. M.
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Design and conduct of 'Xtreme Alps': a double-blind, randomised controlled study of the effects of dietary nitrate supplementation on acclimatisation to high altitude.
Contemporary Clinical Trials,
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10.1016/j.cct.2013.09.002Maher, A. R., Arif, S., Madhani, M., Abozguia, K., Ahmed, I.
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Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite.
British Journal of Pharmacology,
169(3), 659-670. DOI:
10.1111/bph.12152Pacheco, L. G. C., Castro, T. L. P., Carvalho, R. D., Moraes, P. M., Dorella, F. A., Carvalho, N. B., ... Azevedo, V. (2012).
A role for sigma factor ?(E) in Corynebacterium pseudotuberculosis resistance to nitric oxide/peroxide stress.
Frontiers in Microbiology,
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10.3389/fmicb.2012.00126Milsom, A. B., Fernandez, B. O., Garcia-Saura, M. F., Rodriguez, J.
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Contributions of nitric oxide synthases, dietary nitrite/nitrate, and other sources to the formation of NO signaling products.
Antioxidants & Redox Signaling,
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10.1089/ars.2011.4156Cortese-Krott, M. M., Rodriguez-Mateos, A., Sansone, R., Kuhnle, G. G. C., Thasian-Sivarajah, S., Krenz, T., ... Kelm, M. (2012).
Human red blood cells at work: identification and visualization of erythrocytic eNOS activity in health and disease.
Blood,
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10.1182/blood-2012-07-442277Fago, A., Jensen, F. B., Tota, B.
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Integrating nitric oxide, nitrite and hydrogen sulfide signaling in the physiological adaptations to hypoxia: a comparative approach.
Comparative Biochemistry and Physiology. Part A: Molecular & Integrative Physiology,
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10.1016/j.cbpa.2012.01.011Garcia-Saura, M-F., Saijo, F., Bryan, N. S., Bauer, S., Rodriguez, J.
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Nitroso-redox status and vascular function in marginal and severe ascorbate deficiency.
Antioxidants & Redox Signaling,
17(7), 937-950. DOI:
10.1089/ars.2011.4201Berra, L., Coppadoro, A., Yu, B., Lei, C., Spagnolli, E., Steinbicker, A. U., ... Zapol, W. M. (2012).
Transfusion of stored autologous blood does not alter reactive hyperemia index in healthy volunteers.
Anesthesiology,
117(1), 56-63. DOI:
10.1097/ALN.0b013e31825575e6Siervo, M., Tomatis, V., Blossom, C. M. S.
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VEGF is indirectly associated with NO production.
European Journal of Clinical Investigation,
42(9), 967-973. DOI:
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An integrated approach to assessing nitroso-redox balance in systemic inflammation.
Free Radical Biology and Medicine,
51(6), 1137-1145. DOI:
10.1016/j.freeradbiomed.2011.06.012Levett, D. Z., Fernandez, B. O., Riley, H. L., Martin, D. S., Mitchell, K., Leckstrom, C. A.
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The role of nitrogen oxides in human adaptation to hypoxia.
Scientific Reports,
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The role of vascular myoglobin in nitrite-mediated blood vessel relaxation.
Cardiovascular Research,
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Application of an optimized total N-nitrosamine (TONO) assay to pools: placing N-nitrosodimethylamine (NDMA) determinations into perspective.
Environmental Science and Technology Library,
44(9), 3369-3375. DOI:
10.1021/es100361fGarcia-Saura, M. F., Fernandez, B. O., McAllister, B. P., Whitlock, D. R., Cruikshank, W. W.
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Dermal nitrite application enhances global nitric oxide availability: new therapeutic potential for immunomodulation? Journal of Investigative Dermatology,
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Hyperoxia-induced lung injury in gamma-glutamyl transferase deficiency is associated with alterations in nitrosative and nitrative stress.
The American Journal of Pathology,
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Is sunlight good for our heart? European Heart Journal,
31(9), 1041-1045. DOI:
10.1093/eurheartj/ehq069 Saijo, F., Milsom, A. B., Bryan, N. S., Bauer, S. M., Vowinkel, T., Ivanovic, M.
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On the dynamics of nitrite, nitrate and other biomarkers of nitric oxide production in inflammatory bowel disease.
Nitric Oxide,
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Redox-sensitivity and site-specificity of S- and N- denitrosation in proteins.
PLoS ONE,
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Balancing role of nitric oxide in complement-mediated activation of platelets from mCd59a and mCd59b double-knockout mice.
American Journal of Hematology,
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10.1002/ajh.21363Lim, C. C., Bryan, N. S., Jain, M., Garcia-Saura, M. F., Fernandez, B. O., Sawyer, D. B., ... Liao, R. (2009).
Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms.
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