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Ammonium tetrathiomolybdate following ischemia/reperfusion injury: chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models.
PLoS Medicine,
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Cephalosporin-3’ -diazeniumdiolate NO-donor prodrug PYRRO-C3D enhances azithromycin susceptibility of Non-typeable Haemophilus influenzae biofilms.
Antimicrobial Agents and Chemotherapy,
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Cephalosporin-NO-donor prodrug PYRRO-C3D shows β-lactam-mediated activity against Streptococcus pneumoniae biofilms.
Nitric Oxide. DOI:
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Changes in acute pulmonary vascular responsiveness to hypoxia during a progressive ascent to high altitude (5,300 m).
Experimental Physiology,
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Does hypoxia play a role in the development of sarcopenia in humans? Mechanistic insights from the Caudwell Xtreme Everest Expedition: hypoxemia and sarcopenia in humans.
Redox Biology.
Ormerod, J. O. M., Evans, J. D. W., Contractor, H., Beretta, M., Arif, S.
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Human second window pre-conditioning and post-conditioning by nitrite is influenced by a common polymorphism in mitochondrial aldehyde dehydrogenase.
JACC. Basic to translational science,
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Low plasma homoarginine concentration is associated with high rates of all-cause mortality in renal transplant recipients.
Amino Acids,
49(7), 1193-1202. DOI:
10.1007/s00726-017-2420-7Howlin, R. P., Cathie, K., Hall-Stoodley, L., Cornelius, V.
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Low-dose nitric oxide as targeted anti-biofilm adjunctive therapy to treat chronic Pseudomonas aeruginosa infection in cystic fibrosis.
Molecular Therapy. DOI:
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Metabolic basis to Sherpa altitude adaption.
Proceedings of the National Academy of Sciences. DOI:
10.1073/pnas.1700527114Fleury, N.
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Sub-erythemal ultraviolet radiation reduces metabolic dysfunction in already overweight mice.
Journal of Endocrinology,
233(1), 81-92. DOI:
10.1530/JOE-16-0616Lee, E. S., Boldo, L. S.
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Suppression of TAK1 pathway by shear stress counteracts the inflammatory endothelial cell phenotype induced by oxidative stress and TGF-β1.
Scientific Reports,
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The reactive species interactome: Evolutionary emergence, biological significance, and opportunities for redox metabolomics and personalized medicine.
Antioxidants & Redox Signaling. DOI:
10.1089/ars.2017.7083Gilbert-Kawai, E., Coppel, J., Bountziouka, V., Ince, C., Martin, D.
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A comparison of the quality of image acquisition between the incident dark field and sidestream dark field video-microscopes.
BMC Medical Imaging, 1-5. DOI:
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A randomized double-blind placebo controlled crossover trial of sodium nitrate in patients with stable angina INAS.
Future Cardiology,
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10.2217/fca-2016-0026McIlvenna, L., Monaghan, C., Liddle, L.
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Beetroot juice versus chard gel: a pharmacokinetic and pharmacodynamic comparison of nitrate bioavailability. Nitric Oxide, 1-7. DOI:
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Effects of dietary nitrate supplementation on symptoms of acute mountain sickness and basic physiological responses in a group of male adolescents during ascent to Mount Everest Base Camp.
Nitric Oxide,
60, 24-31. DOI:
10.1016/j.niox.2016.08.007Heikal, L., Ghezzi, P., Mengozzi, M.
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Erythropoietin and a nonerythropoietic peptide analog promote aortic endothelial cell repair under hypoxic conditions: role of nitric oxide.
Hypoxia,
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Exposure of stored packed erythrocytes to NO prevents transfusion-associated pulmonary hypertension.
Anesthesiology, 1-12. DOI:
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Impaired sodium-dependent adaptation of arterial stiffness in formerly preeclamptic women: the RETAP-vascular study.
American Journal of Physiology: Heart and Circulatory Physiology,
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Inorganic nitrate mimics exercise-stimulated muscular fiber-type switching and myokine and GABA release.
Diabetes, 1-42. DOI:
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Low concentrations of nitric oxide modulate Streptococcus pneumoniae biofilm metabolism and antibiotic tolerance.
Antimicrobial Agents and Chemotherapy,
60(4), 2456-2466. DOI:
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Serum free sulfhydryl status is associated with patient and graft survival in renal transplant recipients.
Free Radical Biology and Medicine,
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Serum free thiols in chronic heart failure.
Pharmacological Research,
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The fate of sulfate in chronic heart failure.
American Journal of Physiology: Heart and Circulatory Physiology, 1-28. DOI:
10.1152/ajpheart.00645.2016Gorman, S., Lucas, R., Allen-Hall, A., Fleury, N.
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Ultraviolet radiation, vitamin D and the development of obesity, metabolic syndrome and type-2 diabetes. Photochemical & Photobiological Sciences, 1-12. DOI:
10.1039/C6PP00274ARoggenbuck, M., Anderson, D., Barfod, K. K.
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Vitamin D and allergic airway disease shape the murine lung microbiome in a sex-specific manner.
Respiratory Research,
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Acute dietary nitrate supplementation and exercise performance in COPD: a double-blind, placebo-controlled, randomised controlled pilot study.
PLoS ONE,
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Can skin exposure to sunlight prevent liver inflammation? Nutrients,
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Design and conduct of Xtreme Everest 2: an observational cohort study of Sherpa and lowlander responses to graduated hypobaric hypoxia.
F1000 Research,
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DL-propargylglycine reduces blood pressure and renal injury but increases kidney weight in angiotensin-II infused rats.
Nitric Oxide,
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Getting the most from venous occlusion plethysmography: proposed methods for the analysis of data with a rest/exercise protocol.
Extreme Physiology & Medicine,
4, 8. DOI:
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Inhaled nitric oxide as an adjunctive treatment for cerebral malaria in children: a phase II randomized open-label clinical trial.
Open Forum Infectious Diseases,
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Key bioactive reaction products of the NO/H2S interaction are S/N-hybrid species, polysulfides, and nitroxyl.
Proceedings of the National Academy of Sciences, 1-10. DOI:
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Nitrate enhances skeletal muscle fatty acid oxidation via a nitric oxide-cGMP-PPAR-mediated mechanism.
BMC Biology,
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Plasma ADMA associates with all-cause mortality in renal transplant recipients.
Amino Acids, 1-9. DOI:
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Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans.
British Journal of Pharmacology,
172, 3341-3352. DOI:
10.1111/bph.13122Ormerod, J. O. M., Arif, S., Mukadam, M., Evans, J. D. W., Beadle, R., Fernandez, B. O., ... Frenneaux, M. P. (2015).
Short-term intravenous sodium nitrite infusion improves cardiac and pulmonary hemodynamics in heart failure patients.
Circulation: Heart failure,
8(3), 565-571. DOI:
10.1161/CIRCHEARTFAILURE.114.001716Berra, L., Pinciroli, R., Stowell, C. P., Wang, L., Yu, B., Fernandez, B. O., ... Zapol, W. M. (2014).
Autologous tansfusion of stored red blood cells increases pulmonary artery pressure.
American Journal of Respiratory and Critical Care Medicine,
190(7), 800-807. DOI:
10.1164/rccm.201405-0850OCAshmore, T.
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Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart.
The Journal of Physiology, 1-17. DOI:
10.1113/jphysiol.2014.275263Siervo, M., Riley, H. L.
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Effects of prolonged exposure to hypobaric hypoxia on oxidative stress, inflammation and gluco-insular regulation: the not-so-sweet price for good regulation. PLoS ONE,
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Inorganic nitrate promotes the browning of white adipose tissue through the nitrate-nitrite-nitric oxide pathway.
Diabetes. DOI:
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Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI).
European Heart Journal, 1-9. DOI:
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Nitrosopersulfide (SSNO-) accounts for sustained NO bioactivity of S-nitrosothiols following reaction with sulfide.
Redox Biology,
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On the chemical biology of the nitrite/sulfide interaction.
Nitric Oxide,
46, 14-24. DOI:
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Pharmacology and therapeutic role of inorganic nitrite and nitrate in vasodilatation. Pharmacology & Therapeutics,
144, 303-320. DOI:
10.1016/j.pharmthera.2014.06.009Umbrello, M., Dyson, A., Bollen Pinto, B.
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Short-term hypoxic vasodilation in vivo is mediated by bioactive nitric oxide metabolites, rather than free nitric oxide derived from haemoglobin-mediated nitrite reduction.
The Journal of Physiology,
592(5), 1061-1075. DOI:
10.1113/jphysiol.2014.255687Ashmore, T.
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Suppression of erythropoiesis by dietary nitrate.
The FASEB Journal,
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The reaction products of sulfide and S-nitrosoglutathione are potent vasorelaxants.
Nitric Oxide,
46, 123-130. DOI:
10.1016/j.niox.2014.12.008Geldenhuys, S., Hart, P. H., Endersby, R., Jacoby, P.
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Ultraviolet radiation suppresses obesity and symptoms of metabolic syndrome independently of vitamin d in mice fed a high-fat diet. Diabetes,
63(11), 3759-3769. DOI:
10.2337/db13-1675Liu, D.
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UVA irradiation of human skin vasodilates arterial vasculature and lowers blood pressure independently of nitric oxide synthase.
Journal of Investigative Dermatology, 1-38. DOI:
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A multi-level analytical approach for detection and visualization of intracellular NO production and nitrosation events using diaminofluoresceins.
Free Radical Biology and Medicine,
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10.1016/j.freeradbiomed.2012.09.008Martin, D. S., Gilbert-Kawai, E. T., Meale, P. M.
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Design and conduct of 'Xtreme Alps': a double-blind, randomised controlled study of the effects of dietary nitrate supplementation on acclimatisation to high altitude.
Contemporary Clinical Trials,
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Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite.
British Journal of Pharmacology,
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10.1111/bph.12152Pacheco, L. G. C., Castro, T. L. P., Carvalho, R. D., Moraes, P. M., Dorella, F. A., Carvalho, N. B., ... Azevedo, V. (2012).
A role for sigma factor ?(E) in Corynebacterium pseudotuberculosis resistance to nitric oxide/peroxide stress.
Frontiers in Microbiology,
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Contributions of nitric oxide synthases, dietary nitrite/nitrate, and other sources to the formation of NO signaling products.
Antioxidants & Redox Signaling,
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10.1089/ars.2011.4156Cortese-Krott, M. M., Rodriguez-Mateos, A., Sansone, R., Kuhnle, G. G. C., Thasian-Sivarajah, S., Krenz, T., ... Kelm, M. (2012).
Human red blood cells at work: identification and visualization of erythrocytic eNOS activity in health and disease.
Blood,
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Integrating nitric oxide, nitrite and hydrogen sulfide signaling in the physiological adaptations to hypoxia: a comparative approach.
Comparative Biochemistry and Physiology. Part A: Molecular & Integrative Physiology,
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Nitroso-redox status and vascular function in marginal and severe ascorbate deficiency.
Antioxidants & Redox Signaling,
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10.1089/ars.2011.4201Berra, L., Coppadoro, A., Yu, B., Lei, C., Spagnolli, E., Steinbicker, A. U., ... Zapol, W. M. (2012).
Transfusion of stored autologous blood does not alter reactive hyperemia index in healthy volunteers.
Anesthesiology,
117(1), 56-63. DOI:
10.1097/ALN.0b013e31825575e6Siervo, M., Tomatis, V., Blossom, C. M. S.
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VEGF is indirectly associated with NO production.
European Journal of Clinical Investigation,
42(9), 967-973. DOI:
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An integrated approach to assessing nitroso-redox balance in systemic inflammation.
Free Radical Biology and Medicine,
51(6), 1137-1145. DOI:
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The role of nitrogen oxides in human adaptation to hypoxia.
Scientific Reports,
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The role of vascular myoglobin in nitrite-mediated blood vessel relaxation.
Cardiovascular Research,
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Application of an optimized total N-nitrosamine (TONO) assay to pools: placing N-nitrosodimethylamine (NDMA) determinations into perspective.
Environmental Science and Technology Library,
44(9), 3369-3375. DOI:
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Dermal nitrite application enhances global nitric oxide availability: new therapeutic potential for immunomodulation? Journal of Investigative Dermatology,
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Hyperoxia-induced lung injury in gamma-glutamyl transferase deficiency is associated with alterations in nitrosative and nitrative stress.
The American Journal of Pathology,
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Is sunlight good for our heart? European Heart Journal,
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On the dynamics of nitrite, nitrate and other biomarkers of nitric oxide production in inflammatory bowel disease.
Nitric Oxide,
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Redox-sensitivity and site-specificity of S- and N- denitrosation in proteins.
PLoS ONE,
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Balancing role of nitric oxide in complement-mediated activation of platelets from mCd59a and mCd59b double-knockout mice.
American Journal of Hematology,
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Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms.
American Journal of Physiology: Heart and Circulatory Physiology,
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Isotope tracing enhancement of chemiluminescence assays for nitric oxide research.
Biological Chemistry,
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Mechanistic insights into nitrite-induced cardioprotection using an integrated metabolomic/proteomic approach.
Circulation Research,
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Nitrate and nitrite in biology, nutrition and therapeutics.
Nature Chemical Biology,
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Nitrite as regulator of hypoxic signaling in mammalian physiology.
Medicinal Research Reviews,
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Brief periods of nitric oxide inhalation protect against myocardial ischemia-reperfusion injury.
Anesthesiology,
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Modulation of nitrosative stress by S-nitrosoglutathione reductase is critical for thermotolerance and plant growth in Arabidopsis.
The Plant Cell,
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