Phone:: (023) 8120 6891
Email:: M.Feelisch@soton.ac.uk

Professor Martin Feelisch MSc, PhD

Professor of Experimental Medicine and Integrative Biology

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Martin is Professor of Experimental Medicine and Integrative Biology within Medicine at the University of Southampton.

In biology, a finite number of regulatory modules and organising principles suffice to support life and are used by microbes, plants and mammals alike. As a Systems Biologist (with a predilection toward evolutionary thought and a knack for analytical chemistry) I am interested in unraveling the significance of nitric oxide and sulfur in its various forms for human physiology. Specifically, I aim to understand how their production and availabilities are regulated in the face of rapidly changing demands as a function of nutrient and oxygen supply, physical activity and interaction with the environment; and – above all - how this is orchestrated at the cellular, organ and whole body level.

After the study of pharmacy Martin earned his PhD in pharmacology from the Heinrich-Heine University in Dusseldorf in 1988. He was appointed to the Personal Chair of Experimental Medicine & Integrative Biology at Southampton University in April 2012, following a number of other senior research positions in both academia and industry in the USA and Europe.

Qualifications

BSc/MSc (Diploma), Pharmacy, Heinrich-Heine University, Dusseldorf, 1985
PhD (summa cum laude), Pharmacology, Heinrich-Heine University, 1988
Specialist for Drug Information, Apothekerkammer Nordrhein, 1992
Expert in Pharmacology, German Society for Experimental & Clinical Pharmacology and Toxicology (DGPT), 1992
Habilitation (venia legendi), Pharmacology and Toxicology, University of Cologne, 1997

Appointments held

Professor of Experimental Medicine & Integrative Biology, University of Southampton, Faculty of Medicine, 2012-present
Professor of Experimental Medicine and Biology, University of Warwick Medical School and Warwick Systems Biology Centre (MRC Strategic Appointment),
2007-2012
Professor of Medicine and Biochemistry, Adjunct Professor of Pharmacology, Boston University School of Medicine (Boston, USA), 2003-2007
Professor of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center (Shreveport, USA), 1999-2003
Senior Lecturer & Scientific Coordinator, The Wolfson Institute for Biomedical Research, University College London, 1997-1999
Director of Pharmacology, Schwarz Pharma (Monheim, Germany), 1991-1997
Department Head, Pharmacology, Schwarz Pharma, 1990-1991
Visiting Research Scientist, The Wellcome Research Laboratories, Beckenham, 1989/90
Postdoctoral Research Fellow, Pharmacology, Heinrich Heine University (Germany), 1988-1989

Research

Responsibilities

Publications

Honours and Services

Contact

Research interests

Martin has a long-standing interest in analytical chemistry, cardiovascular pharmacology, nutrition and metabolism, photobiology, disease mechanisms, and the chemical biology of nitric oxide (NO), nitroxyl (HNO), and sulfide in its various forms (H₂S, HS^-, R-SSxH). His more recent interests focus on the interconversion of nitrogen and sulfur species and related storage forms in the context of intermediary metabolism, the role of sunlight and the skin microbiome for cardiovascular health, mechanisms of adaptation to hypoxia and altitude as well as the significance of chemical interactions between reactive oxygen, nitrogen and sulfur species (ROS, RNS, RSS) for mitochondrial function and redox signalling in humans. Work in his laboratory is both hypothesis- and curiosity-driven and includes basic as well as translational research projects in all of the above areas. Current development efforts in his lab focus on targeted metabolomic approaches (‘redox metabolomics’) to disentangle the mechanisms of redox regulation in health and disease.

Research group

Clinical and Experimental Sciences

Affiliate research group

Institute for Life Sciences

Postgraduate Supervision

Supervision of 6 MMedSc, 1 BMedSc, 2 MD, and 8 PhD students (Germany, USA, UK)
Current supervision of 1 Masters and 3 PhD students.

External Assessor/Examiner/Promotor/Opponent

2002 Neesha Suvarna (University of Tennessee)
2007 Eliza Tsou (University of Buffalo)
2008 Sarah Fox (University of Edinburgh)
2008 Megan Mowbray (University of Edinburgh)
2012 Rasmus Aamand Olesen (Aarhus University)
2014 Johanna van Langen (Antwerp University)
2015 Anne-Roos S Frenay (University of Groningen)
2017 Ammar W Ashor (Newcastle University)
2017 Anne Koning (Groningen University)

Articles

Sutton, T. R., Minnion, M., Barbarino, F., Koster, G., Fernandez, B. O., Cumpstey, A. F., ... Feelisch, M. (2018). A robust and versatile mass spectrometry platform for comprehensive assessment of the thiol redox metabolome. Redox Biology, 16, 359-380. DOI: 10.1016/j.redox.2018.02.012
Cortese-Krott, M. M., Mergia, E., Kramer, C. M., Luckstadt, W., Yang, J., Wolff, G., ... Kelm, M. (2018). Identification of a soluble guanylate cyclase in RBCs: preserved activity in patients with coronary artery disease. Redox Biology, 14, 328-337. DOI: 10.1016/j.redox.2017.08.020
Bianco, C. L., Savitsky, A., Feelisch, M., & Cortese-Krott, M. M. (2018). Investigations on the role of hemoglobin in sulfide metabolism by intact human red blood cells. Biochemical Pharmacology, 149, 163-173. DOI: 10.1016/j.bcp.2018.01.045
Murray, A. J., Montgomery, H., Grocott, M., Feelisch, M., & Martin, D. S. (2018). Metabolic adjustment to high-altitude hypoxia: from genetic signals to physiological implications. . Biochemical Society Transactions, 46(3), 599-607. DOI: 10.1042/BST20170502
Olson, K. R., Gao, Y., Arif, F., Arora, K., Patel, S., DeLeon, E. R., ... Straub, K. D. (2018). Metabolism of hydrogen sulfide (H2S) and production of Reactive Sulfur Species (RSS) by superoxide dismutase. Redox Biology, 15, 74-85. DOI: 10.1016/j.redox.2017.11.009
Borgognone, A., Shantsila, E., Worrall, S. M., Prompunt, E., Loka, T., Loudon, B. L., ... Madhani, M. (2018). Nitrite circumvents platelet resistance to nitric oxide in patients with heart failure preserved ejection fraction and chronic atrial fibrillation. Cardiovascular Research, 114(10), 1313–1323. DOI: 10.1093/cvr/cvy087
Erkens, R., Suvorava, T., Sutton, T. R., Fernandez, B. O., Mikus-Lelinska, M., Barbarino, F., ... Cortese-Krott, M. M. (2018). Nrf2 deficiency unmasks the significance of nitric oxide synthase activity for cardioprotection. Oxidative Medicine and Cellular Longevity, 2018, 1-16. [8309698]. DOI: 10.1155/2018/8309698
Bogdándi, V., Ida, T., Sutton, T. R., Bianco, C., Ditrói, T., Koster, G., ... Nagy, P. (2018). Speciation of reactive sulfur species and their reactions with alkylating agents: do we have any clue about what is present inside the cell? British Journal of Pharmacology. DOI: 10.1111/bph.14394
Monaghan, C., McIlvenna, L. C., Liddle, L., Burleigh, M., Weller, R. B., Fernandez, B. O., ... Easton, C. (2018). The effects of two different doses of ultraviolet-A light exposure on nitric oxide metabolites and cardiorespiratory outcomes. European Journal of Applied Physiology, 118(5), 1043-1052. DOI: 10.1007/s00421-018-3835-x
Dyson, A., Dal-Pizzol, F., Sabbatini, G., Lach, A. B., Galfo, F., Dos Santos Cardoso, J., ... Singer, M. (2017). Ammonium tetrathiomolybdate following ischemia/reperfusion injury: chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models. PLoS Medicine, 14(7), 1-24. [e1002310]. DOI: 10.1371/journal.pmed.1002310
Collins, S. A., Kelso, M. J., Rineh, A., Yepuri, N. R., Coles, J., Jackson, C. L., ... Allan, R. N. (2017). Cephalosporin-3’ -diazeniumdiolate NO-donor prodrug PYRRO-C3D enhances azithromycin susceptibility of Non-typeable Haemophilus influenzae biofilms. Antimicrobial Agents and Chemotherapy, 61(2), e02086-16. DOI: 10.1128/AAC.02086-16
Allan, R., Kelso, M. J., Rineh, A., Yepuri, N. R., Feelisch, M., Soren, O., ... Faust, S. (2017). Cephalosporin-NO-donor prodrug PYRRO-C3D shows β-lactam-mediated activity against Streptococcus pneumoniae biofilms. Nitric Oxide. DOI: 10.1016/j.niox.2017.02.006
Luks, A. M., Levett, D., Martin, D. S., Goss, C., Mitchell, K., Fernandez, B. O., ... Caudwell Xtreme Everest Investigators (2017). Changes in acute pulmonary vascular responsiveness to hypoxia during a progressive ascent to high altitude (5,300 m). Experimental Physiology, 102(6), 711-724. DOI: 10.1113/EP086083
Akaike, T., Ida, T., Wei, F., Nishida, M., Kumagai, Y., Alam, M. M., ... Motohashi, H. (2017). Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics. Nature Communications, 8(1), [1177]. DOI: 10.1038/s41467-017-01311-y
Wandrag, L., Siervo, M., Riley, H., Khosravid, . M., Fernandez, B., Leckstrom, C. A., ... Feelisch, M. (2017). Does hypoxia play a role in the development of sarcopenia in humans? Mechanistic insights from the Caudwell Xtreme Everest Expedition. Redox Biology, 13, 60-68. DOI: 10.1016/j.redox.2017.05.004
Cumpstey, A. F., Hennis, P. J., Gilbert-kawai, E. T., Fernandez, B. O., Poudevigne, M., Cobb, A., ... Martin, D. S. (2017). Effects of dietary nitrate on respiratory physiology at high altitude: results from the Xtreme Alps study. Nitric Oxide, 71, 57-68. DOI: 10.1016/j.niox.2017.10.005
Ormerod, J. O. M., Evans, J. D. W., Contractor, H., Beretta, M., Arif, S., Fernandez, B. O., ... Ashrafian, H. (2017). Human second window pre-conditioning and post-conditioning by nitrite is influenced by a common polymorphism in mitochondrial aldehyde dehydrogenase. JACC. Basic to translational science, 2(1), 13-21. DOI: 10.1016/j.jacbts.2016.11.006
Aghagolzadeh, P., Radpour, R., Bachtler, M., van Goor, H., Smith, E. R., Lister, A., ... Pasch, A. (2017). Hydrogen sulfide attenuates calcification of vascular smooth muscle cells via KEAP1/NRF2/NQO1 activation. Atherosclerosis, 265, 78-86. DOI: 10.1016/j.atherosclerosis.2017.08.012
Schwarz, K., Singh, S., Parasuraman, S., Rudd, A., Shepstone, L., Feelisch, M., ... Frenneaux, M. P. (2017). Inorganic nitrate in angina study: A randomized double-blind placebo-controlled trial. Journal of the American Heart Association, 6(9), [e006478]. DOI: 10.1161/JAHA.117.006478
Kayacelebi, A. A., Minović, I., Hanff, E., Frenay, A-R. S., de Borst, M. H., Feelisch, M., ... Tsikas, D. (2017). Low plasma homoarginine concentration is associated with high rates of all-cause mortality in renal transplant recipients. Amino Acids, 49(7), 1193-1202. DOI: 10.1007/s00726-017-2420-7
Howlin, R. P., Cathie, K., Hall-Stoodley, L., Cornelius, V., Duignan, C., Allan, R. N., ... Webb, J. S. (2017). Low-dose nitric oxide as targeted anti-biofilm adjunctive therapy to treat chronic Pseudomonas aeruginosa infection in cystic fibrosis. Molecular Therapy, 25(9), 2104-2116. DOI: 10.1016/j.ymthe.2017.06.021
Horscroft, J. A., Kotwica, A. O., Laner, V., West, J. A., Hennis, P. J., Levett, D. Z. H., ... Murray, A. J. (2017). Metabolic basis to Sherpa altitude adaption. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1700527114
Fleury, N., Feelisch, M., Hart, P. H., Weller, R. B., Smoothy, J., Matthews, V. B., & Gorman, S. (2017). Sub-erythemal ultraviolet radiation reduces metabolic dysfunction in already overweight mice. Journal of Endocrinology, 233(1), 81-92. DOI: 10.1530/JOE-16-0616
Lee, E. S., Boldo, L. S., Fernandez, B. O., Feelisch, M., & Harmsen, M. C. (2017). Suppression of TAK1 pathway by shear stress counteracts the inflammatory endothelial cell phenotype induced by oxidative stress and TGF-β1. Scientific Reports, 7, 42487. DOI: 10.1038/srep42487
Cortese-Krott, M. M., Koning, A., Kuhnle, G. G., Nagy, P., Bianco, C., Pasch, A., ... Feelisch, M. (2017). The reactive species interactome: Evolutionary emergence, biological significance, and opportunities for redox metabolomics and personalized medicine. Antioxidants & Redox Signaling, 27(10), 684-712. DOI: 10.1089/ars.2017.7083
Gilbert-Kawai, E., Coppel, J., Bountziouka, V., Ince, C., Martin, D., & Feelisch, M. (2016). A comparison of the quality of image acquisition between the incident dark field and sidestream dark field video-microscopes. BMC Medical Imaging, 1-5. DOI: 10.1186/s12880-015-0078-8
Schwarz, K., Singh, S., Parasuraman, S., Bruce, M., Shepstone, L., Feelisch, M., ... Frenneaux, M. (2016). A randomized double-blind placebo controlled crossover trial of sodium nitrate in patients with stable angina INAS. Future Cardiology, 12(6), 617-626. DOI: 10.2217/fca-2016-0026
McIlvenna, L., Monaghan, C., Liddle, L., Fernandez, B., Feelisch, M., Muggeridge, D., & Easton, C. (2016). Beetroot juice versus chard gel: a pharmacokinetic and pharmacodynamic comparison of nitrate bioavailability. Nitric Oxide, 1-7. DOI: 10.1016/j.niox.2016.12.006
Hennis, P. J., Mitchell, K., Gilbert-Kawai, E., Bountziouka, V., Wade, A., Feelisch, M., ... Martin, D. S. (2016). Effects of dietary nitrate supplementation on symptoms of acute mountain sickness and basic physiological responses in a group of male adolescents during ascent to Mount Everest Base Camp. Nitric Oxide, 60, 24-31. DOI: 10.1016/j.niox.2016.08.007
Heikal, L., Ghezzi, P., Mengozzi, M., Feelisch, M., Stelmaszczuk, B., & Ferns, G. A. A. (2016). Erythropoietin and a nonerythropoietic peptide analog promote aortic endothelial cell repair under hypoxic conditions: role of nitric oxide. Hypoxia, 4, 121-133. DOI: 10.2147/HP.S104377
Muenster, S., Beloiartsev, A., Yu, B., Du, E., Abidi, S., Dao, M., ... Zapol, W. M. (2016). Exposure of stored packed erythrocytes to NO prevents transfusion-associated pulmonary hypertension. Anesthesiology, 1-12. DOI: 10.1097/ALN.0000000000001294
van der Graaf, A. M., Paauw, N. D., Toering, T. J., Feelisch, M., Faas, M. M., Sutton, T. R., ... Lely, A. T. (2016). Impaired sodium-dependent adaptation of arterial stiffness in formerly preeclamptic women: the RETAP-vascular study. American Journal of Physiology: Heart and Circulatory Physiology, 310(11), H1827-H1833. DOI: 10.1152/ajpheart.00010.2016
Roberts, L., Ashmore, T., McNally, B., Murfitt, S., Fernandez, B., Feelisch, M., ... Griffin, J. (2016). Inorganic nitrate mimics exercise-stimulated muscular fiber-type switching and myokine and GABA release. Diabetes, 1-42. DOI: 10.2337/db16-0843
Cortese-Krott, M. M., Butler, A. R., Woollins, J. D., & Feelisch, M. (2016). Inorganic sulfur–nitrogen compounds: from gunpowder chemistry to the forefront of biological signaling. Dalton Transactions, 45(14), 5908-5919. DOI: 10.1039/c5dt05034k
Allan, R. N., Morgan, S., Brito-Mutunayagam, S., Skipp, P., Feelisch, M., Hayes, S. M., ... Hall-Stoodley, L. (2016). Low concentrations of nitric oxide modulate Streptococcus pneumoniae biofilm metabolism and antibiotic tolerance. Antimicrobial Agents and Chemotherapy, 60(4), 2456-2466. DOI: 10.1128/AAC.02432-15
Cortese-Krott, M. M., Pullmann, D., & Feelisch, M. (2016). Nitrosopersulfide (SSNO(-)) targets the Keap-1/Nrf2 redox system. Pharmacological Research, 1-44. DOI: 10.1016/j.phrs.2016.09.022
Frenay, A-R. S., de Borst, M. H., Bachtler, M., Tschopp, N., Keyzer, C. A., van den Berg, E., ... van Goor, H. (2016). Serum free sulfhydryl status is associated with patient and graft survival in renal transplant recipients. Free Radical Biology and Medicine, 99, 345-351. DOI: 10.1016/j.freeradbiomed.2016.08.024
Koning, A. M., Meijers, W. C., Pasch, A., Leuvenink, H. G. D., Frenay, A-R. S., Dekker, M. M., ... van Goor, H. (2016). Serum free thiols in chronic heart failure. Pharmacological Research, 111, 452-458. DOI: 10.1016/j.phrs.2016.06.027
Koning, A., Meijers, W., Minovic, I., Post, A., Feelisch, M., Pasch, A., ... van Goor, H. (2016). The fate of sulfate in chronic heart failure. American Journal of Physiology: Heart and Circulatory Physiology, 1-28. DOI: 10.1152/ajpheart.00645.2016
Gorman, S., Lucas, R., Allen-Hall, A., Fleury, N., & Feelisch, M. (2016). Ultraviolet radiation, vitamin D and the development of obesity, metabolic syndrome and type-2 diabetes. Photochemical & Photobiological Sciences, 1-12. DOI: 10.1039/C6PP00274A
Roggenbuck, M., Anderson, D., Barfod, K. K., Feelisch, M., Geldenhuys, S., Sørensen, S. J., ... Gorman, S. (2016). Vitamin D and allergic airway disease shape the murine lung microbiome in a sex-specific manner. Respiratory Research, 17(116), 1-18. DOI: 10.1186/s12931-016-0435-3
Curtis, K. J., O'Brien, K. A., Tanner, R. J., Polkey, J. I., Minnion, M., Feelisch, M., ... Hopkinson, N. S. (2015). Acute dietary nitrate supplementation and exercise performance in COPD: a double-blind, placebo-controlled, randomised controlled pilot study. PLoS ONE, 10(12), 1-18. DOI: 10.1371/journal.pone.0144504
Gorman, S., Black, L. J., Feelisch, M., Hart, P. H., & Weller, R. (2015). Can skin exposure to sunlight prevent liver inflammation? Nutrients, 7(5), 3219-3239. DOI: 10.3390/nu7053219
Gilbert-Kawai, E., Sheperdigian, A., Adams, T., Mitchell, K., Feelisch, M., Murray, A., ... Martin, D. (2015). Design and conduct of Xtreme Everest 2: an observational cohort study of Sherpa and lowlander responses to graduated hypobaric hypoxia. F1000 Research, 4, 90. DOI: 10.12688/f1000research.6297.1
Oosterhuis, N. R., Frenay, A-R. S., Wesseling, S., Snijder, P. M., Slaats, G. G., Yazdani, S., ... van Goor, H. (2015). DL-propargylglycine reduces blood pressure and renal injury but increases kidney weight in angiotensin-II infused rats. Nitric Oxide, 49, 56-66. DOI: 10.1016/j.niox.2015.07.001
Wythe, S., Davies, T., Martin, D., Feelisch, M., & Gilbert-Kawai, E. (2015). Getting the most from venous occlusion plethysmography: proposed methods for the analysis of data with a rest/exercise protocol. Extreme Physiology & Medicine, 4, 8. DOI: 10.1186/s13728-015-0027-8
Mwanga-Amumpaire, J., Carroll, R. W., Baudin, E., Kemigisha, E., Nampijja, D., Mworozi, K., ... Zapol, W. M. (2015). Inhaled nitric oxide as an adjunctive treatment for cerebral malaria in children: a phase II randomized open-label clinical trial. Open Forum Infectious Diseases, 2(3), 1-9. DOI: 10.1093/ofid/ofv111
Cortese-Krott, M., Kuhnle, G., Fernandez, B. O., Grman, M., DuMond, J., Barrow, M., ... Feelisch, M. (2015). Key bioactive reaction products of the NO/H2S interaction are S/N-hybrid species, polysulfides, and nitroxyl. Proceedings of the National Academy of Sciences, 1-10. DOI: 10.1073/pnas.1509277112
Ashmore, T., Roberts, L. D., Morash, A. J., Kotwica, A. O., Finnerty, J., West, J. A., ... Murray, A. J. (2015). Nitrate enhances skeletal muscle fatty acid oxidation via a nitric oxide-cGMP-PPAR-mediated mechanism. BMC Biology, 13(110), 1-17. DOI: 10.1186/s12915-015-0221-6
Frenay, A-R. S., van den Berg, E., de Borst, M. H., Beckmann, B., Tsikas, D., Feelisch, M., ... van Goor, H. (2015). Plasma ADMA associates with all-cause mortality in renal transplant recipients. Amino Acids, 1-9. DOI: 10.1007/s00726-015-2023-0
Arif, S., Borgognone, A., Lin, E. L-S., O'Sullivan, A. G., Sharma, V., Drury, N. E., ... Madhani, M. (2015). Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans. British Journal of Pharmacology, 172, 3341-3352. DOI: 10.1111/bph.13122
Ormerod, J. O. M., Arif, S., Mukadam, M., Evans, J. D. W., Beadle, R., Fernandez, B. O., ... Frenneaux, M. P. (2015). Short-term intravenous sodium nitrite infusion improves cardiac and pulmonary hemodynamics in heart failure patients. Circulation: Heart failure, 8(3), 565-571. DOI: 10.1161/CIRCHEARTFAILURE.114.001716
Berra, L., Pinciroli, R., Stowell, C. P., Wang, L., Yu, B., Fernandez, B. O., ... Zapol, W. M. (2014). Autologous tansfusion of stored red blood cells increases pulmonary artery pressure. American Journal of Respiratory and Critical Care Medicine, 190(7), 800-807. DOI: 10.1164/rccm.201405-0850OC
Ashmore, T., Fernandez, B. O., Branco-Price, C., West, J. A., Cowburn, A. S., Heather, L. C., ... Murray, A. J. (2014). Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart. The Journal of Physiology, 1-17. DOI: 10.1113/jphysiol.2014.275263
Siervo, M., Riley, H. L., Fernandez, B. O., Leckstrom, C. A., Martin, D. S., Mitchell, K., ... Feelisch, M. (2014). Effects of prolonged exposure to hypobaric hypoxia on oxidative stress, inflammation and gluco-insular regulation: the not-so-sweet price for good regulation. PLoS ONE, 9(4), e94915. DOI: 10.1371/journal.pone.0094915
Roberts, L. D., Ashmore, T., Kotwica, A. O., Murfitt, S. A., Fernandez, B. O., Feelisch, M., ... Griffin, J. L. (2014). Inorganic nitrate promotes the browning of white adipose tissue through the nitrate-nitrite-nitric oxide pathway. Diabetes. DOI: 10.2337/db14-0496
Siddiqi, N., Neil, C., Bruce, M., Maclennan, G., Cotton, S., Papadopoulou, S., ... Frenneaux, M. (2014). Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI). European Heart Journal, 1-9. DOI: 10.1093/eurheartj/ehu096
Cortese-Krott, M. M., Fernandez, B. O., Santos, J. L. T., Mergia, E., Grman, M., Nagy, P., ... Feelisch, M. (2014). Nitrosopersulfide (SSNO-) accounts for sustained NO bioactivity of S-nitrosothiols following reaction with sulfide. Redox Biology, 2, 234-244. DOI: 10.1016/j.redox.2013.12.031
Cortese-Krott, M. M., Fernandez, B. O., Kelm, M., Butler, A. R., & Feelisch, M. (2014). On the chemical biology of the nitrite/sulfide interaction. Nitric Oxide, 46, 14-24. DOI: 10.1016/j.niox.2014.12.009
Bailey, J. C., Feelisch, M., Horowitz, J. D., Frenneaux, M. P., & Madhani, M. (2014). Pharmacology and therapeutic role of inorganic nitrite and nitrate in vasodilatation. Pharmacology & Therapeutics, 144, 303-320. DOI: 10.1016/j.pharmthera.2014.06.009
Umbrello, M., Dyson, A., Bollen Pinto, B., Fernandez, B. O., Simon, V., Feelisch, M., & Singer, M. (2014). Short-term hypoxic vasodilation in vivo is mediated by bioactive nitric oxide metabolites, rather than free nitric oxide derived from haemoglobin-mediated nitrite reduction. The Journal of Physiology, 592(5), 1061-1075. DOI: 10.1113/jphysiol.2014.255687
Ashmore, T., Fernandez, B. O., Evans, C. E., Huang, Y., Branco-Price, C., Griffin, J. L., ... Murray, A. J. (2014). Suppression of erythropoiesis by dietary nitrate. The FASEB Journal, 29(3), 1102-1112. DOI: 10.1096/fj.14-263004
Berenyiova, A., Grman, M., Mijuskovic, A., Stasko, A., Misak, A., Nagy, P., ... Ondrias, K. (2014). The reaction products of sulfide and S-nitrosoglutathione are potent vasorelaxants. Nitric Oxide, 46, 123-130. DOI: 10.1016/j.niox.2014.12.008
Geldenhuys, S., Hart, P. H., Endersby, R., Jacoby, P., Feelisch, M., Weller, R. B., ... Gorman, S. (2014). Ultraviolet radiation suppresses obesity and symptoms of metabolic syndrome independently of vitamin d in mice fed a high-fat diet. Diabetes, 63(11), 3759-3769. DOI: 10.2337/db13-1675
Liu, D., Fernandez, B. O., Hamilton, A., Lang, N. N., Gallagher, J. M. C., Newby, D. E., ... Weller, R. B. (2014). UVA irradiation of human skin vasodilates arterial vasculature and lowers blood pressure independently of nitric oxide synthase. Journal of Investigative Dermatology, 1-38. DOI: 10.1038/jid.2014.27
Feelisch, M., Gorman, S., & Weller, R. B. (2014). Vitamin D status and ill health. The Lancet Diabetes & Endocrinology, 2(4), e8. DOI: 10.1016/S2213-8587(14)70043-9
Cortese-Krott, M. M., Rodriguez-Mateos, A., Kuhnle, G., Brown, G., Feelisch, M., & Kelm, M. (2013). A multi-level analytical approach for detection and visualization of intracellular NO production and nitrosation events using diaminofluoresceins. Free Radical Biology and Medicine, 53, 2146-2158. DOI: 10.1016/j.freeradbiomed.2012.09.008
Martin, D. S., Gilbert-Kawai, E. T., Meale, P. M., Fernandez, B. O., Cobb, A., Khosravi, M., ... Feelisch, M. (2013). Design and conduct of 'Xtreme Alps': a double-blind, randomised controlled study of the effects of dietary nitrate supplementation on acclimatisation to high altitude. Contemporary Clinical Trials, 36(2), 450-459. DOI: 10.1016/j.cct.2013.09.002
Feelisch, M., & Olson, K. R. (2013). Embracing sulfide and CO to understand nitric oxide biology. Nitric Oxide, 2-4. DOI: 10.1016/j.niox.2013.06.004
Maher, A. R., Arif, S., Madhani, M., Abozguia, K., Ahmed, I., Fernandez, B. O., ... Frenneaux, M. P. (2013). Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite. British Journal of Pharmacology, 169(3), 659-670. DOI: 10.1111/bph.12152
Umbrello, M., Dyson, A., Feelisch, M., & Singer, M. (2013). The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching. Antioxidants & Redox Signaling, 19(14), 1690-710. DOI: 10.1089/ars.2012.4979
Pacheco, L. G. C., Castro, T. L. P., Carvalho, R. D., Moraes, P. M., Dorella, F. A., Carvalho, N. B., ... Azevedo, V. (2012). A role for sigma factor ?(E) in Corynebacterium pseudotuberculosis resistance to nitric oxide/peroxide stress. Frontiers in Microbiology, 3(126). DOI: 10.3389/fmicb.2012.00126
Milsom, A. B., Fernandez, B. O., Garcia-Saura, M. F., Rodriguez, J., & Feelisch, M. (2012). Contributions of nitric oxide synthases, dietary nitrite/nitrate, and other sources to the formation of NO signaling products. Antioxidants & Redox Signaling, 17(3), 422-432. DOI: 10.1089/ars.2011.4156
Cortese-Krott, M. M., Rodriguez-Mateos, A., Sansone, R., Kuhnle, G. G. C., Thasian-Sivarajah, S., Krenz, T., ... Kelm, M. (2012). Human red blood cells at work: identification and visualization of erythrocytic eNOS activity in health and disease. Blood, 120, 4229-4237. DOI: 10.1182/blood-2012-07-442277
Fago, A., Jensen, F. B., Tota, B., Feelisch, M., Olson, K. R., Helbo, S., ... Skovgaard, N. (2012). Integrating nitric oxide, nitrite and hydrogen sulfide signaling in the physiological adaptations to hypoxia: a comparative approach. Comparative Biochemistry and Physiology. Part A: Molecular & Integrative Physiology, 162(1), 1-6. DOI: 10.1016/j.cbpa.2012.01.011
Garcia-Saura, M-F., Saijo, F., Bryan, N. S., Bauer, S., Rodriguez, J., & Feelisch, M. (2012). Nitroso-redox status and vascular function in marginal and severe ascorbate deficiency. Antioxidants & Redox Signaling, 17(7), 937-950. DOI: 10.1089/ars.2011.4201
Berra, L., Coppadoro, A., Yu, B., Lei, C., Spagnolli, E., Steinbicker, A. U., ... Zapol, W. M. (2012). Transfusion of stored autologous blood does not alter reactive hyperemia index in healthy volunteers. Anesthesiology, 117(1), 56-63. DOI: 10.1097/ALN.0b013e31825575e6
Siervo, M., Tomatis, V., Blossom, C. M. S., Feelisch, M., & Bluck, L. C. J. (2012). VEGF is indirectly associated with NO production. European Journal of Clinical Investigation, 42(9), 967-973. DOI: 10.1111/j.1365-2362.2012.02684.x
Dyson, A., Bryan, N. S., Fernandez, B. O., Garcia-Saura, M-F., Saijo, F., Mongardon, N., ... Feelisch, M. (2011). An integrated approach to assessing nitroso-redox balance in systemic inflammation. Free Radical Biology and Medicine, 51(6), 1137-1145. DOI: 10.1016/j.freeradbiomed.2011.06.012
Siervo, M., Stephan, B. C. M., Feelisch, M., & Bluck, L. J. C. (2011). Measurement of in vivo nitric oxide synthesis in humans using stable isotopic methods: a systematic review. Free Radical Biology & Medicine, 51(4), 795-804. DOI: 10.1016/j.freeradbiomed.2011.05.032
Levett, D. Z., Fernandez, B. O., Riley, H. L., Martin, D. S., Mitchell, K., Leckstrom, C. A., ... Feelisch, M. (2011). The role of nitrogen oxides in human adaptation to hypoxia. Scientific Reports, 1(109). DOI: 10.1038/srep00109
Ormerod, J. O. M., Ashrafian, H., Maher, A. R., Arif, S., Steeples, V., Born, G. V. R., ... Frenneaux, M. P. (2011). The role of vascular myoglobin in nitrite-mediated blood vessel relaxation. Cardiovascular Research, 89(3), 560-565. DOI: 10.1093/cvr/cvq299
Kulshrestha, P., McKinstry, K. C., Fernandez, B. O., Feelisch, M., & Mitch, W. A. (2010). Application of an optimized total N-nitrosamine (TONO) assay to pools: placing N-nitrosodimethylamine (NDMA) determinations into perspective. Environmental Science and Technology Library, 44(9), 3369-3375. DOI: 10.1021/es100361f
Garcia-Saura, M. F., Fernandez, B. O., McAllister, B. P., Whitlock, D. R., Cruikshank, W. W., & Feelisch, M. (2010). Dermal nitrite application enhances global nitric oxide availability: new therapeutic potential for immunomodulation? Journal of Investigative Dermatology, 130(2), 608-611. DOI: 10.1038/jid.2009.303
Klings, E. S., Lowry, M. H., Li, G., Jean, J-C., Fernandez, B. O., Garcia-Saura, M. F., ... Joyce-Brady, M. (2010). Hyperoxia-induced lung injury in gamma-glutamyl transferase deficiency is associated with alterations in nitrosative and nitrative stress. The American Journal of Pathology, 175(6), 2309-2318. DOI: 10.2353/ajpath.2009.081017
Feelisch, M., Kolb-Bachofen, V., Liu, D., Lundberg, J. O., Revelo, L. P., Suschek, C. V., & Weller, R. B. (2010). Is sunlight good for our heart? European Heart Journal, 31(9), 1041-1045. DOI: 10.1093/eurheartj/ehq069
Saijo, F., Milsom, A. B., Bryan, N. S., Bauer, S. M., Vowinkel, T., Ivanovic, M., ... Feelisch, M. (2010). On the dynamics of nitrite, nitrate and other biomarkers of nitric oxide production in inflammatory bowel disease. Nitric Oxide, 22(2), 155-167. DOI: 10.1016/j.niox.2009.11.009
Jourd'heuil, F. L., Lowery, A. M., Melton, E. M., Mnaimneh, S., Bryan, N. S., Fernandez, B. O., ... Jourd'heuil, D. (2010). Redox-sensitivity and site-specificity of S- and N- denitrosation in proteins. PLoS ONE, 5(12), e14400-[10pp]. DOI: 10.1371/journal.pone.0014400
Qin, X., Hu, W., Song, W., Blair, P., Wu, G., Hu, X., ... Halperin, J. A. (2009). Balancing role of nitric oxide in complement-mediated activation of platelets from mCd59a and mCd59b double-knockout mice. American Journal of Hematology, 84(4), 221-227. DOI: 10.1002/ajh.21363
Lim, C. C., Bryan, N. S., Jain, M., Garcia-Saura, M. F., Fernandez, B. O., Sawyer, D. B., ... Liao, R. (2009). Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms. American Journal of Physiology: Heart and Circulatory Physiology, 297(6), H2144-H2153. DOI: 10.1152/ajpheart.00673.2009
Cornelius, J., Tran, T., Turner, N., Piazza, A., Mills, L., Slack, R., ... Rodriguez, J. (2009). Isotope tracing enhancement of chemiluminescence assays for nitric oxide research. Biological Chemistry, 390(2), 181-189. DOI: 10.1515/BC.2009.017
Perlman, D. H., Bauer, S. M., Ashrafian, H., Bryan, N. S., Garcia-Saura, M. F., Lim, C. C., ... Feelisch, M. (2009). Mechanistic insights into nitrite-induced cardioprotection using an integrated metabolomic/proteomic approach. Circulation Research, 104(6), 796-804. DOI: 10.1161/CIRCRESAHA.108.187005
Lundberg, J. O., Gladwin, M. T., Ahluwalia, A., Benjamin, N., Bryan, N. S., Butler, A., ... Weitzberg, E. (2009). Nitrate and nitrite in biology, nutrition and therapeutics. Nature Chemical Biology, 5(12), 865-869. DOI: 10.1038/nchembio.260
van Faassen, E. E., Bahrami, S., Feelisch, M., Hogg, N., Kelm, M., Kim-Shapiro, D. B., ... Gladwin, M. T. (2009). Nitrite as regulator of hypoxic signaling in mammalian physiology. Medicinal Research Reviews, 29(5), 683-741. DOI: 10.1002/med.20151
Nagasaka, Y., Fernandez, B. O., Garcia-Saura, M. F., Petersen, B., Ichinose, F., Bloch, K. D., ... Zapol, W. M. (2008). Brief periods of nitric oxide inhalation protect against myocardial ischemia-reperfusion injury. Anesthesiology, 109(4), 675-682. DOI: 10.1097/ALN.0b013e318186316e
Lee, U., Wie, C., Fernandez, B. O., Feelisch, M., & Vierling, E. (2008). Modulation of nitrosative stress by S-nitrosoglutathione reductase is critical for thermotolerance and plant growth in Arabidopsis. The Plant Cell, 20(3), 786-802. DOI: 10.1105/tpc.107.052647
Feelisch, M. (2008). The chemical biology of nitric oxide--an outsider's reflections about its role in osteoarthritis. Osteoarthritis and Cartilage, 16, S3-S13. DOI: 10.1016/S1063-4584(08)60007-2
Butler, A. R., & Feelisch, M. (2008). Therapeutic uses of inorganic nitrite and nitrate: from the past to the future. Circulation, 117(16), 2151-2159. DOI: 10.1161/CIRCULATIONAHA.107.753814
Feelisch, M., Fernandez, B. O., Bryan, N. S., Garcia-Saura, M. F., Bauer, S., Whitlock, D. R., ... Ashrafian, H. (2008). Tissue processing of nitrite in hypoxia: an intricate interplay of nitric oxide-generating and -scavenging systems. The Journal of Biological Chemistry, 283(49), 33927-33934. DOI: 10.1074/jbc.M806654200
Erzurum, S. C., Ghosh, S., Janocha, A. J., Xu, W., Bauer, S., Bryan, N. S., ... Beall, C. M. (2007). Higher blood flow and circulating NO products offset high-altitude hypoxia among Tibetans. Proceedings of the National Academy of Sciences of the United States of America, 104(45), 17593-175988. DOI: 10.1073/pnas.0707462104
Feelisch, M. (2007). Nitrated cyclic GMP as a new cellular signal. Nature Chemical Biology, 3(11), 687-688. DOI: 10.1038/nchembio1107-687
Elrod, J. W., Greer, J. J. M., Bryan, N. S., Langston, W., Szot, J. F., Gebregzlabher, H., ... Lefer, D. J. (2006). Cardiomyocyte-specific overexpression of NO synthase-3 protects against myocardial ischemia-reperfusion injury. Arteriosclerosis, Thrombosis, and Vascular Biology, 26(7), 1517-1523. DOI: 10.1161/01.ATV.0000224324.52466.e6
Lundberg, J. O., Feelisch, M., Björne, H., Jansson, E., & Weitzberg, E. (2006). Cardioprotective effects of vegetables: is nitrate the answer? Nitric Oxide, 15(4), 359-362. DOI: 10.1016/j.niox.2006.01.013
Duranski, M. R., Elrod, J. W., Calvert, J. W., Bryan, N. S., Feelisch, M., & Lefer, D. J. (2006). Genetic overexpression of eNOS attenuates hepatic ischemia-reperfusion injury. American Journal of Physiology: Heart and Circulatory Physiology, 291(6), H2980-H2986. DOI: 10.1152/ajpheart.01173.2005
Wang, X., Bryan, N. S., MacArthur, P. H., Rodriguez, J., Gladwin, M. T., & Feelisch, M. (2006). Measurement of nitric oxide levels in the red cell: validation of tri-iodide-based chemiluminescence with acid-sulfanilamide pretreatment. The Journal of Biological Chemistry, 281(37), 26994-27002. DOI: 10.1074/jbc.M603953200
Peyrot, F., Fernandez, B. O., Bryan, N. S., Feelisch, M., & Ducrocq, C. (2006). N-Nitroso products from the reaction of indoles with Angeli's salt. Chemical Research in Toxicology, 19(1), 58-67. DOI: 10.1021/tx050253b
Kleinbongard, P., Dejam, A., Lauer, T., Jax, T., Kerber, S., Gharini, P., ... Kelm, M. (2006). Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans. Advances in Free Radical Biology & Medicine, 40(2), 295-302. DOI: 10.1016/j.freeradbiomed.2005.08.025
Heiss, C., Lauer, T., Dejam, A., Kleinbongard, P., Hamada, S., Rassaf, T., ... Kelm, M. (2006). Plasma nitroso compounds are decreased in patients with endothelial dysfunction. Journal of the American College of Cardiology, 47(3), 573-579. DOI: 10.1016/j.jacc.2005.06.089
Donzelli, S., Switzer, C. H., Thomas, D. D., Ridnour, L. A., Espey, M. G., Isenberg, J. S., ... Wink, D. A. (2006). The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: a new feature of nitrogen oxide signaling. Antioxidants & Redox Signaling, 8(7-8), 1363-1371. DOI: 10.1089/ars.2006.8.1363
Bryan, N. S., Fernandez, B. O., Bauer, S. M., Garcia-Saura, M. F., Milsom, A. B., Rassaf, T., ... Feelisch, M. (2005). Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues. Nature Chemical Biology, 1(5), 290-297. DOI: 10.1038/nchembio734
Zamora, R., Bryan, N. S., Boyle, P., Wong, C., Milsom, A. B., Jaffe, R., ... Ford, H. R. (2005). Nitrosative stress in an animal model of necrotizing enterocolitis. Free Radical Biology and Medicine, 39(11), 1428-37. DOI: 10.1016/j.freeradbiomed.2005.07.004
Rodriguez, J., Specian, V., Maloney, R., Jourd'heuil, D., & Feelisch, M. (2005). Performance of diamino fluorophores for the localization of sources and targets of nitric oxide. Free Radical Biology and Medicine, 38(3), 356-68. DOI: 10.1016/j.freeradbiomed.2004.10.036
Ridnour, L. A., Thomas, D. D., Mancardi, D., Espey, M. G., Miranda, K. M., Paolocci, N., ... Wink, D. A. (2005). The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations. Biological Chemistry, 385(1), 1-10. DOI: 10.1515/BC.2004.001
Gladwin, M. T., Schechter, A. N., Kim-Shapiro, D. B., Patel, R. P., Hogg, N., Shiva, S., ... Lundberg, J. O. (2005). The emerging biology of the nitrite anion. Nature Chemical Biology, 1(6), 308-314. DOI: 10.1038/nchembio1105-308
Bryan, N. S., Rassaf, T., Rodriguez, J., & Feelisch, M. (2004). Bound NO in human red blood cells: fact or artifact? Nitric Oxide, 10(4), 221-228. DOI: 10.1016/j.niox.2004.04.008
Tao, L., Gao, E., Bryan, N. S., Qu, Y., Liu, H-R., Hu, A., ... Ma, X. L. (2004). Cardioprotective effects of thioredoxin in myocardial ischemia and reperfusion: role of S-nitrosation [corrected]. Proceedings of the National Academy of Sciences of the United States of America, 101(31), 11471-11476. DOI: 10.1073/pnas.0402941101
Bryan, N. S., Rassaf, T., Maloney, R. E., Rodriguez, C. M., Saijo, F., Rodriguez, J. R., & Feelisch, M. (2004). Cellular targets and mechanisms of nitros(yl)ation: an insight into their nature and kinetics in vivo. Proceedings of the National Academy of Sciences, 101(12), 4308-4313. DOI: 10.1073/pnas.0306706101
Rassaf, T., Feelisch, M., & Kelm, M. (2004). Circulating NO pool: assessment of nitrite and nitroso species in blood and tissues. Free Radical Biology and Medicine, 36(4), 413-422. DOI: 10.1016/j.freeradbiomed.2003.11.011
Janero, D. R., Bryan, N. S., Saijo, F., Dhawan, V., Schwalb, D. J., Warren, M. C., & Feelisch, M. (2004). Differential nitros(yl)ation of blood and tissue constituents during glyceryl trinitrate biotransformation in vivo. Proceedings of the National Academy of Sciences, 101(48), 16958-16963. DOI: 10.1073/pnas.0406075101
Reif, A., Shutenko, Z. V., Feelisch, M., & Schmidt, H. H. H. W. (2004). Superoxide dismutase and catalase are required to detect •NO from both coupled and uncoupled neuronal no synthase. Advances in Free Radical Biology & Medicine, 37(7), 988-997. DOI: 10.1016/j.freeradbiomed.2004.07.005
Miranda, K. M., Paolocci, N., Katori, T., Thomas, D. D., Ford, E., Bartberger, M. D., ... Wink, D. A. (2003). A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system. Proceedings of the National Academy of Sciences of the United States of America, 100(16), 9196-9201. DOI: 10.1073/pnas.1430507100
Rodriguez, J., Maloney, R. E., Rassaf, T., Bryan, N. S., & Feelisch, M. (2003). Chemical nature of nitric oxide storage forms in rat vascular tissue. Proceedings of the National Academy of Sciences of the United States of America, 100(1), 336-341. DOI: 10.1073/pnas.0234600100
Miranda, K. M., Nims, R. W., Thomas, D. D., Espey, M. G., Citrin, D., Bartberger, M. D., ... Wink, D. A. (2003). Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins. A chemical discussion of the differential biological effects of these redox related products of NOS. Journal of Inorganic Biochemistry, 93(1-2), 52-60. DOI: 10.1016/S0162-0134(02)00498-1
Lauer, T., Kleinbongard, P., Preik, M., Rauch, B. H., Deussen, A., Feelisch, M., ... Kelm, M. (2003). Direct biochemical evidence for eNOS stimulation by bradykinin in the human forearm vasculature. Basic Research in Cardiology, 98(2), 84-89. DOI: 10.1007/s003950300000
Pagliaro, P., Mancardi, D., Rastaldo, R., Penna, C., Gattullo, D., Miranda, K. M., ... Paolocci, N. (2003). Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning. Free Radical Biology and Medicine, 34(1), 33-43. DOI: 10.1016/S0891-5849(02)01179-6
Feelisch, M. (2003). Nitroxyl gets to the heart of the matter. Proceedings of the National Academy of Sciences of the United States of America, 100(9), 4978-4980. DOI: 10.1073/pnas.1031571100
Rassaf, T., Bryan, N. S., Maloney, R. E., Specian, V., Kelm, M., Kalyanaraman, B., ... Feelisch, M. (2003). NO adducts in mammalian red blood cells: too much or too little? Nature Medicine, 9(5), 481-482. DOI: 10.1038/nm0503-481
Wink, D. A., Miranda, K. M., Katori, T., Mancardi, D., Thomas, D. D., Ridnour, L., ... Paolocci, N. (2003). Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm. American Journal of Physiology: Heart and Circulatory Physiology, 285(6), H2264-H2276. DOI: 10.1152/ajpheart.00531.2003
Jourd'heuil, D., Jourd'heuil, F. L., & Feelisch, M. (2003). Oxidation and nitrosation of thiols at low micromolar exposure to nitric oxide. Evidence for a free radical mechanism. The Journal of Biological Chemistry, 278(18), 15720-15726. DOI: 10.1074/jbc.M300203200
Kleinbongard, P., Dejam, A., Lauer, T., Rassaf, T., Schindler, A., Picker, O., ... Kelm, M. (2003). Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals. Free Radical Biology and Medicine, 35(7), 790-796. DOI: 10.1016/S0891-5849(03)00406-4
Dejam, A., Kleinbongard, P., Rassaf, T., Hamada, S., Gharini, P., Rodriguez, J., ... Kelm, M. (2003). Thiols enhance NO formation from nitrate photolysis. Free Radical Biology and Medicine, 35(12), 1551-1559. DOI: 10.1016/j.freeradbiomed.2003.09.009
Rassaf, T., Bryan, N. S., Kelm, M., & Feelisch, M. (2002). Concomitant presence of N-nitroso and S-nitroso proteins in human plasma. Free Radical Biology and Medicine, 33(11), 1590-1596. DOI: 10.1016/S0891-5849(02)01183-8
Feelisch, M., Rassaf, T., Mnaimneh, S., Singh, N., Bryan, N. S., Jourd'Heuil, D., & Kelm, M. (2002). Concomitant S-, N-, and heme-nitros(yl)ation in biological tissues and fluids: implications for the fate of NO in vivo. The FASEB Journal, 16(13), 1775-1785. DOI: 10.1096/fj.02-0363com
Rassaf, T., Preik, M., Kleinbongard, P., Lauer, T., Heiß, C., Strauer, B-E., ... Kelm, M. (2002). Evidence for in vivo transport of bioactive nitric oxide in human plasma. Journal of Clinical Investigation, 109(9), 1241-1248. DOI: 10.1172/JCI14995
Thomas, D. D., Miranda, K. M., Espey, M. G., Citrin, D., Jourd'heuil, D., Paolocci, N., ... Wink, D. A. (2002). Guide for the use of nitric oxide (NO) donors as probes of the chemistry of NO and related redox species in biological systems. Methods in Enzymology, 359, 84-105. DOI: 10.1016/S0076-6879(02)59174-6
Joshi, M. S., Ferguson, T. B., Han, T. H., Hyduke, D. R., Liao, J. C., Rassaf, T., ... Lancaster, J. R. (2002). Nitric oxide is consumed, rather than conserved, by reaction with oxyhemoglobin under physiological conditions. Proceedings of the National Academy of Sciences of the United States of America, 99(16), 10341-6. DOI: 10.1073/pnas.152149699
Cerwinka, W. H., Cooper, D., Krieglstein, C. F., Feelisch, M., & Granger, D. N. (2002). Nitric oxide modulates endotoxin-induced platelet-endothelial cell adhesion in intestinal venules. American Journal of Physiology: Heart and Circulatory Physiology, 282(3), H1111-H1117. DOI: 10.1152/ajpheart.00391.2001
Rassaf, T., Kleinbongard, P., Preik, M., Dejam, A., Gharini, P., Lauer, T., ... Kelm, M. (2002). Plasma nitrosothiols contribute to the systemic vasodilator effects of intravenously applied NO: experimental and clinical Study on the fate of NO in human blood. Circulation Research, 91(6), 470-477. DOI: 10.1161/01.RES.0000035038.41739.CB
Wink, D. A., Miranda, K. M., Espey, M. G., Pluta, R. M., Hewett, S. J., Colton, C., ... Grisham, M. B. (2001). Mechanisms of the antioxidant effects of nitric oxide. Antioxidants & Redox Signaling, 3(2), 203-213. DOI: 10.1089/152308601300185179
Paolocci, N., Saavedra, W. F., Miranda, K. M., Martignani, C., Isoda, T., Hare, J. M., ... Kass, D. A. (2001). Nitroxyl anion exerts redox-sensitive positive cardiac inotropy in vivo by calcitonin gene-related peptide signaling. Proceedings of the National Academy of Sciences of the United States of America, 98(18), 10463-10468. DOI: 10.1073/pnas.181191198
Reif, A., Zecca, L., Riederer, P., Feelisch, M., & Schmidt, H. H. H. W. (2001). Nitroxyl oxidizes NADPH in a superoxide dismutase inhibitable manner. Free Radical Biology and Medicine, 30(7), 803-8. DOI: 10.1016/S0891-5849(01)00477-4
Lauer, T., Preik, M., Rassaf, T., Strauer, B. E., Deussen, A., Feelisch, M., & Kelm, M. (2001). Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action. Proceedings of the National Academy of Sciences of the United States of America, 98(22), 12814-12819. DOI: 10.1073/pnas.221381098
Miranda, K. M., Espey, M. G., Yamada, K., Krishna, M., Ludwick, N., Kim, S., ... Wink, D. A. (2001). Unique oxidative mechanisms for the reactive nitrogen oxide species, nitroxyl anion. The Journal of Biological Chemistry, 276(3), 1720-1727. DOI: 10.1074/jbc.M006174200
Marley, R., Feelisch, M., Holt, S., & Moore, K. (2000). A chemiluminescense-based assay for S-nitrosoalbumin and other plasma S-nitrosothiols. Free Radical Research, 32(1), 1-9. DOI: 10.1080/10715760000300011
Orsi, A., Beltrán, B., Clementi, E., Hallén, K., Feelisch, M., & Moncada, S. (2000). Continuous exposure to high concentrations of nitric oxide leads to persistent inhibition of oxygen consumption by J774 cells as well as extraction of oxygen by the extracellular medium. Biochemical Journal, 346, 407-412.
Jourd'heuil, D., Hallén, K., Feelisch, M., & Grisham, M. B. (2000). Dynamic state of S-nitrosothiols in human plasma and whole blood. Free Radical Biology and Medicine, 28(3), 409-417. DOI: 10.1016/S0891-5849(99)00257-9
Komarov, A. M., Wink, D. A., Feelisch, M., & Schmidt, H. H. H. W. (2000). Electron-paramagnetic resonance spectroscopy using N-methyl-D-glucamine dithiocarbamate iron cannot discriminate between nitric oxide and nitroxyl: implications for the detection of reaction products for nitric oxide synthase. Free Radical Biology and Medicine, 28(5), 739-742. DOI: 10.1016/S0891-5849(00)00156-8
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Wolzt, M., MacAllister, R. J., Davis, D., Feelisch, M., Moncada, S., Vallance, P., & Hobbs, A. J. (1999). Biochemical characterization of S-nitrosohemoglobin. Mechanisms underlying synthesis, no release, and biological activity. The Journal of Biological Chemistry, 274(41), 28983-28990. DOI: 10.1074/jbc.274.41.28983
Ma, X. L., Gao, F., Liu, G-L., Lopez, B. L., Christopher, T. A., Fukuto, J. M., ... Feelisch, M. (1999). Opposite effects of nitric oxide and nitroxyl on postischemic myocardial injury. Proceedings of the National Academy of Sciences, 96(25), 14617-14622. DOI: 10.1073/pnas.96.25.14617
Ji, G. J., Fleischmann, B. K., Bloch, W., Feelisch, M., Andressen, C., Addicks, K., & Hescheler, J. (1999). Regulation of the L-type Ca2+ channel during cardiomyogenesis: switch from NO to adenylyl cyclase-mediated inhibition. The FASEB Journal, 13(2), 313-324.
Feelisch, M., Kotsonis, P., Siebe, J., Clement, B., & Schmidt, H. H. H. W. (1999). The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3,-a] quinoxalin-1-one is a nonselective heme protein inhibitor of nitric oxide synthase and other cytochrome P-450 enzymes involved in nitric oxide donor bioactivation. Molecular Pharmacology, 56(2), 243-253.
Clementi, E., Brown, G. C., Feelisch, M., & Moncada, S. (1998). Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione. Proceedings of the National Academy of Sciences, 95(13), 7631-7636.
Mitchell, J. B., DeGraff, W., Kim, S., Cook, J. A., Gamson, J., Christodoulou, D., ... Wink, D. A. (1998). Redox generation of nitric oxide to radiosensitize hypoxic cells. International Journal of Radiation Oncology*Biology*Physics, 42(4), 795-798. DOI: 10.1016/S0360-3016(98)00327-7
Liu, G-L., Christopher, T. A., Lopez, B. L., Gao, F., Guo, Y., Gao, E., ... Ma, X. L. (1998). SP/W-5186, A cysteine-containing nitric oxide donor, attenuates postischemic myocardial injury. The Journal of Pharmacology and Experimental Therapeutics, 287(2), 527-537.
Wink, D. A., Feelisch, M., Fukuto, J., Chistodoulou, D., Jourd'heuil, D., Grisham, M. B., ... Mitchell, J. B. (1998). The cytotoxicity of nitroxyl: possible implications for the pathophysiological role of NO. Archives of Biochemistry and Biophysics, 351(1), 66-74. DOI: 10.1006/abbi.1997.0565
Feelisch, M. (1998). The use of nitric oxide donors in pharmacological studies. Naunyn-Schmiedeberg's Archives of Pharmacology, 358(1), 113-122. DOI: 10.1007/PL00005231
Kelm, M., Dahmann, R., Wink, D., & Feelisch, M. (1997). The nitric oxide/superoxide assay. Insights into the biological chemistry of the NO/O-2 interaction. The Journal of Biological Chemistry, 272, 9922-9932.
Preik, M., Kelm, M., Feelisch, M., & Strauer, B. E. (1996). Impaired effectiveness of nitric oxide-donors in resistance arteries of patients with arterial hypertension. Journal of Hypertension, 14(7), 903-908.
Schmidt, H. H. H. W., Hofmann, H., Schindler, U., Shutenko, Z. S., Cunningham, D. D., & Feelisch, M. (1996). No?·NO from NO?synthase. Proceedings of the National Academy of Sciences, 93(25), 14492-14497.
Wang, S. Y., Feelisch, M., Harrison, D. G., & Sellke, F. W. (1996). Preferential dilation of large coronary microvessels by the mononitrates SPM-4744 and SPM-5185. Journal of Cardiovascular Pharmacology, 27(4), 587-593.
De Meyer, G. R., Bult, H., Ustünes, L., Kockx, M. M., Feelisch, M., & Herman, A. G. (1995). Effect of nitric oxide donors on neointima formation and vascular reactivity in the collared carotid artery of rabbits. Journal of Cardiovascular Pharmacology, 26(2), 272-279.
Feelisch, M., Brands, F., & Kelm, M. (1995). Human endothelial cells bioactivate organic nitrates to nitric oxide: implications for the reinforcement of endothelial defence mechanisms. European Journal of Clinical Investigation, 25(10), 737-745. DOI: 10.1111/j.1365-2362.1995.tb01952.x
Edling, O., Bao, G., Feelisch, M., Unger, T., & Gohlke, P. (1995). Moexipril, a new angiotensin-converting enzyme (ACE) inhibitor: pharmacological characterization and comparison with enalapril. The Journal of Pharmacology and Experimental Therapeutics, 275(2), 854-863.
Zamora, R., Grzesiok, A., Weber, H., & Feelisch, M. (1995). Oxidative release of nitric oxide accounts for guanylyl cyclase stimulating, vasodilator and anti-platelet activity of Piloty's acid: a comparison with Angeli's salt. Biochemical Journal, 312 (Pt 2), 333-339.
Kelm, M., Feelisch, M., Krebber, T., Deußen, A., Motz, W., & Strauer, B. E. (1995). Role of nitric oxide in the regulation of coronary vascular tone in hearts from hypertensive rats. Maintenance of nitric oxide-forming capacity and increased basal production of nitric oxide. Hypertension, 25(2), 186-93. DOI: 10.1161/01.HYP.25.2.186
Feelisch, M., & Martin, J. F. (1995). The early role of nitric oxide in evolution. Trends in Ecology & Evolution, 10(12), 496-499. DOI: 10.1016/S0169-5347(00)89206-X
Ney, P., & Feelisch, M. (1995). Vasodilator effects of PGE1 in the coronary and systemic circulation of the rat are mediated by ATP-sensitive potassium (K+) channels. Agents and Actions. Supplements, 45, 71-76.
Pino, R. Z., & Feelisch, M. (1994). Bioassay discrimination between nitric oxide (NO) and nitroxyl (NO-) using L-cysteine. Biochemical and Biophysical Research Communications, 201(1), 54-62. DOI: 10.1006/bbrc.1994.1668
Addicks, K., Bloch, W., & Feelisch, M. (1994). Nitric oxide modulates sympathetic neurotransmission at the prejunctional level. Microscopy Research and Technique, 29(2), 161-168. DOI: 10.1002/jemt.1070290214
Zanzinger, J., Feelisch, M., & Bassenge, E. (1994). Novel organic nitrates are potent dilators of large coronary arteries with reduced development of tolerance during long-term infusion in dogs: role of the sulfhydryl moiety. Journal of Cardiovascular Pharmacology, 23(5), 772-778.
Moro, M. Á., Darley-Usmar, V. M., Goodwin, D. A., Read, N. G., Zamora-Pino, R., Feelisch, M., ... Moncada, S. (1994). Paradoxical fate and biological action of peroxynitrite on human platelets. Proceedings of the National Academy of Sciences, 91(14), 6702-6706.
Feelisch, M., te Poel, M., Zamora, R., Deussen, A., & Moncada, S. (1994). Understanding the controversy over the identity of EDRF. Nature, 368(6466), 62-65. DOI: 10.1038/368062a0
Feelisch, M. (1993). [Nitrogen monoxide (NO)- the active principle of organic nitrates]. Schweizerische Rundschau für Medizin Praxis, 82(42), 1167-1171.
Feelisch, M. (1993). Biotransformation to nitric oxide of organic nitrates in comparison to other nitrovasodilators. European Heart Journal, 14, 123-132. DOI: 10.1093/eurheartj/14.suppl.1
Kelm, M., Feelisch, M., Krebber, T., Motz, W., & Strauer, B. E. (1993). Mechanisms of histamine-induced coronary vasodilatation: H1-receptor-mediated release of endothelium-derived nitric oxide. Journal of Vascular Research, 30(3), 132-138. DOI: 10.1159/000158987
Kelm, M., Feelisch, M., Krebber, T., Motz, W., & Strauer, B. E. (1992). The role of nitric oxide in the regulation of coronary vascular resistance in arterial hypertension: comparison of normotensive and spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology, 20, S183-S186.
Feelisch, M., Schönafingeri, K., & Noack, E. (1992). Thiol-mediated generation of nitric oxide accounts for the vasodilator action of furoxans. Biochemical Pharmacology, 44(6), 1149-1157. DOI: 10.1016/0006-2952(92)90379-w
Feelisch, M., & Kelm, M. (1991). Biotransformation of organic nitrates to nitric oxide by vascular smooth muscle and endothelial cells. Biochemical and Biophysical Research Communications, 180(1), 286-293. DOI: 10.1016/S0006-291X(05)81290-2
McCall, T. B., Feelisch, M., Palmer, R. M., & Moncada, S. (1991). Identification of N-iminoethyl-L-ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells. British Journal of Pharmacology, 102(1), 234-238.
Noack, E., & Feelisch, M. (1991). Molecular mechanisms of nitrovasodilator bioactivation. Basic Research in Cardiology, 86, 37-50.
Kelm, M., Feelisch, M., Deussen, A., Strauer, B. E., & Schrader, J. (1991). Release of endothelium derived nitric oxide in relation to pressure and flow. Cardiovascular Research, 25(10), 831-836. DOI: 10.1093/cvr/25.10.831
Noack, E., & Feelisch, M. (1989). Molecular aspects underlying the vasodilator action of molsidomine. Journal of Cardiovascular Pharmacology, 14, S1-S5.
Feelisch, M., Ostrowski, J., & Noack, E. (1989). On the mechanism of NO release from sydnonimines. Journal of Cardiovascular Pharmacology, 14, S13-S22.
Kelm, M., Feelisch, M., & Schrader, J. (1989). Release of the free nitric oxide radical (NO) and EDRF from endothelial cells. Zeitschrift für Kardiologie, 78, 70-74.
Feelisch, M., Noack, E., & Schröder, H. (1988). Explanation of the discrepancy between the degree of organic nitrate decomposition, nitrite formation and guanylate cyclase stimulation. European Heart Journal, 9, 57-62. DOI: 10.1093/eurheartj/9.suppl_A.57
Kelm, M., Feelisch, M., Spahr, R., Piper, H-M., Noack, E., & Schrader, J. (1988). Quantitative and kinetic characterization of nitric oxide and EDRF released from cultured endothelial cells. Biochemical and Biophysical Research Communications, 154(1), 236-244. DOI: 10.1016/0006-291X(88)90675-4
Feelisch, M., & Noack, E. A. (1987). Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase. European Journal of Pharmacology, 139(1), 19-30. DOI: 10.1016/0014-2999(87)90493-6
Feelisch, M., & Noack, E. (1987). Nitric oxide (NO) formation from nitrovasodilators occurs independently of hemoglobin or non-heme iron. European Journal of Pharmacology, 142(3), 465-469. DOI: 10.1016/0014-2999(87)90090-2

Review

Fukuto, J. M., Ignarro, L. J., Nagy, P., Wink, D. A., Kevil, C. G., Feelisch, M., ... Akaike, T. (2018). Biological hydropersulfides and related polysulfides: A new concept and perspective in redox biology. FEBS Letters, 592(12), 2140-2152. DOI: 10.1002/1873-3468.13090

Book

Feelisch, M., & Stamler, J. (Eds.) (1996). Methods in nitric oxide research. Chichester, GB: Wiley-Blackwell.

Book Chapters

Kevil, C. G., Cortese-Krott, M. M., Nagy, P., Papapetropoulos, A., Feelisch, M., & Szabo, C. (2017). Cooperative interactions between NO and H2S: chemistry, biology, physiology, pathophysiology. In B. Freeman (Ed.), Nitric Oxide (3rd ed., pp. 57-83). Academic Press. DOI: 10.1016/B978-0-12-804273-1.00005-3
Feelisch, M., & Cumpstey, A. F. (2017). Free radicals in inflammation: from molecular and cellular mechanisms to the clinic. In J-M. Cavaillon, & M. Singer (Eds.), Inflammation: From Molecular and Cellular Mechanisms to the Clinic (1st ed., Vol. 2, pp. 695-726). Wiley-Blackwell.
Whitlock, D., & Feelisch, M. (2009). Soil bacteria, nitrite and the skin. In G. A. W. Rook (Ed.), The Hygiene Hypothesis and Darwinian Medicine (pp. 103-115). Springer. DOI: 10.1007/978-3-7643-8903-1_6

1990 Fritz-Külz-Prize (German Society for Exp & Clin Pharmacology and Toxicology)

Meeting Organisation

1992-present Organization, co-organisation and member of Scientific Advisory Boards of >10 international scientific meetings and workshops (30-650 participants)
2011 Chair Gordon Research Conference on Nitric Oxide

Editorial Board Membership

1993-97 Endothelium
1995-present Nitric Oxide Chemistry and Biology
2005-09 British Journal of Pharmacology
2015-present Pharmacological Research

Advisor Activity

1995 Co-Founder and Director of the "Nitric Oxide Society"
1998-02 Member, Scientific Advisory Board, Vasopharm Biotech GmbH
2003-07 Member, Scientific Advisory Board, NitroMed, Inc.
2011-present Member, Xtreme Everest Scientific Strategy Group
2014-present Member, Scientific Advisory Board, AOBiome
2016-present Member, Scientific Advisory Board, Clinical Sensors
2016-present Member, Scientific Advisory Board, RelaxSol

Service

1990-present ad hoc reviewer for >20 scientific journals
1999-present Reviewer for national and international grant funding bodies
(incl NIH, Wellcome Trust, MRC, BBSRC, BHF, The Royal Society, SFI, DFG, and FWF)
2009 External Peer Review and Member of Site-Visit Team, Trinity College School of Pharmacy, Dublin, Ireland
2013-present Member, NIHR Wellcome Trust Early Phase Safety Committee
2017 Quality Assessment of Research Programs (Peer Review Committee Chair), Faculty of Pharmaceutical Sciences, University of Antwerp, Belgium

Professor Martin Feelisch
CES Academic unit
Level F, South Block, MP810
University of Southampton
Southampton General Hospital
Tremona Road
Southampton SO166YD

Room Number:SGH/LF80/MP810

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