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Research project

Defining the role of ZEB1-dependent epithelial-mesenchymal crosstalk in lung fibrosis

  • Research groups:
  • Lead researchers:
    Dr Yihua Wang
  • Research funder:
    Medical Research Council
  • Status:
    Not active

Project overview

Idiopathic pulmonary fibrosis (IPF) is a life-threatening condition of the lungs where tissue becomes thickened, stiff, and scarred, limiting the amount of oxygen getting into the blood. The aim of this project is to provide effective targeted therapies for sufferers to reduce symptoms of this devastating disease and improve their quality of life as well as to identify biomarkers for IPF patients.

Staff

Lead researchers

Dr Yihua Wang

Associate Professor
Research interests
  • Cell Signalling in Disease
  • Epithelial-Mesenchymal Crosstalk
  • Pulmonary Fibrosis
Connect with Yihua

Email: yihua.wang@soton.ac.uk

Collaborating research institutes, centres and groups

Research outputs

Autophagy in pulmonary fibrosis: friend or foe?
Charlotte Hill & Yihua Wang, 2022, Genes and Diseases, 9(6), 1594-1607
DOI: 10.1016/j.gendis.2021.09.008
Type: review
Integrated analysis reveals effects of bioactive ingredients from Limonium Sinense (Girard) Kuntze on hypoxia-inducible factor (HIF) activation
Hualong Zhao, Siyuan Wang, Yilu Zhou, Ayse Ertay, Philip Williamson, Robert Ewing, Xinhui Tang, Jialian Wang & Yihua Wang, 2022, Frontiers in Plant Science, 13
DOI: 10.3389/fpls.2022.994036
Type: article
Risk factors associated with radiolucent foreign body inhalation in adults: a 10-year retrospective cohort study
Xiaofan Liu, Fang Ni, Tao Guo, Fangfang Jiang, Yan Jiang, Cheng Song, Mingli Yuan, Zhaowu Tao, Mingxin Ye, Junjie Xu, Ying Wang, Qiong Qian, Yi Hu & Yihua Wang, 2022, Respiratory Research, 23
DOI: 10.1186/s12931-022-02165-9
Type: article
Integrated analysis reveals the protective mechanism and therapeutic potential of hyperbaric oxygen against pulmonary fibrosis
Yuan Yuan, Guoqiang Qiao, Jiajiao Zhou, Yilu Zhou, Yali Li, Xia Li, Zhenglin Jiang & Yihua Wang, 2022, Genes and Diseases
DOI: 10.1016/j.gendis.2022.08.012
Type: article
Spatially resolved deconvolution of the fibrotic niche in lung fibrosis
Michael Eyres, Joseph A. Bell, Elizabeth R. Davies, Aurelie Fabre, Aiman Alzetani, Sanjay Jogai, Ben G. Marshall, David. A. Johnston, Zijian Xu, Sophie V. Fletcher, Yihua Wang, Gayle Marshall, Donna E. Davies, Emily Offer & Mark G. Jones, 2022, Cell Reports, 40(7)
DOI: 10.1016/j.celrep.2022.111230
Type: article
Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis
Christopher J. Brereton, Liudi Yao, Elizabeth R. Davies, Yilu Zhou, Milica Vukmirovic, Joseph A. Bell, Siyuan Wang, Robert A. Ridley, Lareb S.N. Dean, Orestis G. Andriotis, Franco Conforti, Lennart Brewitz, Soran Mohammed, Timothy Wallis, Ali Tavassoli, Rob M. Ewing, Aiman Alzetani, Benjamin G. Marshall, Sophie V. Fletcher, Philipp J. Thurner, Aurelie Fabre, Naftali Kaminski, Luca Richeldi, Atul Bhaskar, Christopher J. Schofield, Matthew Loxham, Donna E. Davies, Yihua Wang & Mark G. Jones, 2022, eLife, 11
DOI: 10.7554/eLife.69348
Type: article
Proteomic characterization of GSK3β knockout shows altered cell adhesion and metabolic pathway utilisation in colorectal cancer cells
Emily Bowler-Barnett, Francisco D. Martinez-Garcia, Matthew Sherwood, Ahood Aleidan, Steve John, Sara Weston, Yihua Wang, Nullin Divecha, Paul Skipp & Rob M. Ewing, 2021, PLoS ONE, 16(11), e0246707
DOI: 10.1371/journal.pone.0246707
Type: article