Defining the role of ZEB1-dependent epithelial-mesenchymal crosstalk in lung fibrosis

Project overview

Idiopathic pulmonary fibrosis (IPF) is a life-threatening condition of the lungs where tissue becomes thickened, stiff, and scarred, limiting the amount of oxygen getting into the blood. The aim of this project is to provide effective targeted therapies for sufferers to reduce symptoms of this devastating disease and improve their quality of life as well as to identify biomarkers for IPF patients.

Staff

Lead researcher

Dr Yihua Wang

Associate Professor

Research interests

Cell Signalling in Disease
Epithelial-Mesenchymal Crosstalk
Pulmonary Fibrosis

Connect with Yihua

Email: yihua.wang@soton.ac.uk

Collaborating research institutes, centres and groups

Cell and Developmental Biology

We explore how molecular interactions between proteins and small molecules, defined at atomic resolution, govern biochemical output and in turn control cell behaviour.

Research outputs

Risk factors associated with radiolucent foreign body inhalation in adults: a 10-year retrospective cohort study

Xiaofan Liu,

Fang Ni,

Tao Guo,

Fangfang Jiang,

Yan Jiang,

Cheng Song,

Mingli Yuan,

Zhaowu Tao,

Mingxin Ye,

Junjie Xu,

Ying Wang,

Qiong Qian,

Yi Hu,

& Yihua Wang

, 2022 , Respiratory Research , 23

DOI: 10.1186/s12931-022-02165-9

Type: article

Integrated analysis reveals effects of bioactive ingredients from Limonium Sinense (Girard) Kuntze on hypoxia-inducible factor (HIF) activation

Hualong Zhao,

Siyuan Wang,

Yilu Zhou,

Ayse Ertay,

Philip Williamson,

Robert Ewing,

Xinhui Tang,

Jialian Wang,

& Yihua Wang

, 2022 , Frontiers in Plant Science , 13

DOI: 10.3389/fpls.2022.994036

Type: article

Spatially resolved deconvolution of the fibrotic niche in lung fibrosis

Michael Eyres,

Joseph A. Bell,

Elizabeth R. Davies,

Aurelie Fabre,

Aiman Alzetani,

Sanjay Jogai,

Ben G. Marshall,

David. A. Johnston,

Zijian Xu,

Sophie V. Fletcher,

Yihua Wang,

Gayle Marshall,

Donna E. Davies,

Emily Offer,

Mark G. Jones,

, 2022 , Cell Reports , 40 (7)

DOI: 10.1016/j.celrep.2022.111230

Type: article

Integrated analysis reveals the protective mechanism and therapeutic potential of hyperbaric oxygen against pulmonary fibrosis

Yuan Yuan,

Guoqiang Qiao,

Jiajiao Zhou,

Yilu Zhou,

Yali Li,

Xia Li,

Zhenglin Jiang,

& Yihua Wang

, 2022 , Genes and Diseases

DOI: 10.1016/j.gendis.2022.08.012

Type: article

Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis

Christopher J. Brereton,

Liudi Yao,

Elizabeth R. Davies,

Yilu Zhou,

Milica Vukmirovic,

Joseph A. Bell,

Siyuan Wang,

Robert A. Ridley,

Lareb S.N. Dean,

Orestis G. Andriotis,

Franco Conforti,

Lennart Brewitz,

Soran Mohammed,

Timothy Wallis,

Ali Tavassoli,

Rob M. Ewing,

Aiman Alzetani,

Benjamin G. Marshall,

Sophie V. Fletcher,

Philipp J. Thurner,

Aurelie Fabre,

Naftali Kaminski,

Luca Richeldi,

Atul Bhaskar,

Christopher J. Schofield,

Matthew Loxham,

Donna E. Davies,

Yihua Wang,

Mark G. Jones,

, 2022 , eLife , 11

DOI: 10.7554/eLife.69348

Type: article