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Research project

Defining the role of ZEB1-dependent epithelial-mesenchymal crosstalk in lung fibrosis

  • Research groups:
  • Lead researcher:
  • Research funder:
    Medical Research Council
  • Status:
    Not active

Project overview

Idiopathic pulmonary fibrosis (IPF) is a life-threatening condition of the lungs where tissue becomes thickened, stiff, and scarred, limiting the amount of oxygen getting into the blood. The aim of this project is to provide effective targeted therapies for sufferers to reduce symptoms of this devastating disease and improve their quality of life as well as to identify biomarkers for IPF patients.


Lead researcher

Dr Yihua Wang

Associate Professor

Research interests

  • Cell Signalling in Disease
  • Epithelial-Mesenchymal Crosstalk
  • Pulmonary Fibrosis
Connect with Yihua

Collaborating research institutes, centres and groups

Research outputs

Hualong Zhao, Siyuan Wang, Yilu Zhou, Ayse Ertay, Philip Williamson, Robert Ewing, Xinhui Tang, Jialian Wang & Yihua Wang, 2022, Frontiers in Plant Science, 13
Type: article
Xiaofan Liu, Fang Ni, Tao Guo, Fangfang Jiang, Yan Jiang, Cheng Song, Mingli Yuan, Zhaowu Tao, Mingxin Ye, Junjie Xu, Ying Wang, Qiong Qian, Yi Hu & Yihua Wang, 2022, Respiratory Research, 23
Type: article
Yuan Yuan, Guoqiang Qiao, Jiajiao Zhou, Yilu Zhou, Yali Li, Xia Li, Zhenglin Jiang & Yihua Wang, 2022, Genes and Diseases
Type: article
Michael Eyres, Joseph A. Bell, Elizabeth R. Davies, Aurelie Fabre, Aiman Alzetani, Sanjay Jogai, Ben G. Marshall, David. A. Johnston, Zijian Xu, Sophie V. Fletcher, Yihua Wang, Gayle Marshall, Donna E. Davies, Emily Offer & Mark G. Jones, 2022, Cell Reports, 40(7)
Type: article
Christopher J. Brereton, Liudi Yao, Elizabeth R. Davies, Yilu Zhou, Milica Vukmirovic, Joseph A. Bell, Siyuan Wang, Robert A. Ridley, Lareb S.N. Dean, Orestis G. Andriotis, Franco Conforti, Lennart Brewitz, Soran Mohammed, Timothy Wallis, Ali Tavassoli, Rob M. Ewing, Aiman Alzetani, Benjamin G. Marshall, Sophie V. Fletcher, Philipp J. Thurner, Aurelie Fabre, Naftali Kaminski, Luca Richeldi, Atul Bhaskar, Christopher J. Schofield, Matthew Loxham, Donna E. Davies, Yihua Wang & Mark G. Jones, 2022, eLife, 11
Type: article