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The University of Southampton
Institute for Life Sciences

Integrative Molecular Phenotyping Centre

Southampton’s unique in-depth expertise in multi-omic technologies, combined with access to patient cohorts from world-leading collaborative clinical and commercial partners, aims to transform precision medicine across the disease spectrum from cancer immunology to respiratory conditions.

The Integrative Molecular Phenotyping Centre (IMPC) brings together ’omic experts from across the University to use multi-omic data, in combination with clinical data, to better understand disease and enable more personalised and effective healthcare treatment and diagnosis.

Molecular phenotyping to explore individual variability in genes, environment and lifestyle, allows doctors and researchers to predict more accurately which treatment and prevention strategies for a particular disease will work in which groups of people.

Transforming precision medicine through data analytics

Southampton is in a unique position because we have experts in numerous ’omic technologies and data science and have excellent collaboration with our clinical partners both in the UK and across Europe.

By working together researchers can really understand the mechanisms behind diseases. Not only are we carrying out the innovative research here, but our established clinical links mean we can translate that research into the clinic and through to the patient.

By using molecular signatures from multi omics data - genomics, transcriptomics, proteomics, glycomics and metabolomics-in combination with clinical data, we can enable better tailoring of existing treatments, and pave the way for the development of new  therapeutics and diagnostics for improved patient outcome.

The data that we are generating from this research is huge, and the Integrative Molecular Phenotyping Centre enables us to develop critical new approaches to integrate and analyse this data and extract the information we need from these big datasets.

“The combination of all the work we are doing at Southampton, particularly in the areas of cancer, respiratory and infectious disease, is changing the way we look at disease and places us as leaders in precision medicine.”  Professor Paul Skipp, Head of the IMPC.

Research impact

Southampton is already making an impact in molecular phenotyping and precision medicine:

TopoMD -is a group of scientists and mathematicians from the University whose exciting research is promising to revolutionise healthcare by allowing high resolution investigation of molecular mechanisms underlying disease, and therefore enabling development of targeted treatments for application in personalised medicine. They are using revolutionary topological algorithms to plot the shape of a patient’s gene expression and compare it to the shape of gene expression characteristic of diseases for precise and accurate diagnosis.

Asthma – using clinical and ’omics data from hundreds of adults and children with severe asthma we are able to understand more about different types of asthma to ensure better diagnosis and treatment for each person and uncover new information and ideas that could lead to the creation of effective new treatments. The team has recently identified novel molecular sub-types of asthma that are used in clinical trials to better predict therapeutic efficacy.

Cancer -in collaboration with the Southampton Centre for Cancer Immunology, the team is using multi-omics approaches to identify human leukocyte antigen (HLA) class-I and class-II peptides presented to T-cells in a number of cancers which are crucial for designing innovative personalised therapeutics and vaccines against cancer and other diseases.

Breast cancer – using molecular phenotyping data collected from 3,000patients over five years, we are discovering new biomarkers for assessing the risk of developing secondary breast cancer, breast cancer recurrence and how diet and lifestyle factors could influence the outcome of the disease.

Related Staff Member

Please see a selection of postgraduate courses related to this subject area below.

For the full range of undergraduate and postgraduate courses at the University of Southampton, please visit our courses webpages: https://www.southampton.ac.uk/courses.page 

 

MSc Statistics

This programme includes options ranging from the more theoretical aspects of statistics to those which cover material focussed on real world applications of statistics.

MSc in Statistics with Applications in Medicine

The MSc in Statistics with Applications in Medicine provides training in statistical methodology, with an emphasis on solving practical problems arising in the context of collecting and analysing medical data.

PhD Programme - Medicine

Full and part- time PhD's in a broad range of specialist areas in Medicine, including biomedicine, research in clinical environments and population-based statistical studies.

MSc Genomic Medicine

This programme explores the genomic and informatics of rare and common diseases, cancer and infectious diseases, and the application of these for diagnostics, prognostics and stratified medicine.

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