The University of Southampton
Medicine
Phone:
(023) 8120 6373
Email:
L.R.Green@soton.ac.uk

Dr Lucy Green BSc, PhD

Associate Professor in Developmental Physiology

Dr Lucy Green's photo
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My research uncovers the adaptive responses made by the fetus to changes in nutrition in pregnancy, which have implications for health of skeletal muscle and the cardiovascular system in later life. I am an Associate Professor in Developmental Physiology in the Faculty of Medicine.

It seems that it isn’t just about adult diet and lifestyle – your health may have been determined when you were just a twinkle in your mother’s eye

Dr Lucy Green joined the Faculty of Medicine in 2000 and is based in The Institute of Developmental Sciences (Southampton General Hospital). Her work is part of a strong Faculty theme on the Developmental Origins of Health and Disease. She held a previous academic appointment at University College London (1998-2000) and trained at King’s College London, Cornell University (USA), University College London, and University of Western Ontario (Canada).

She is a member of The Physiological Society, The International Society for Developmental Origins of Health and Disease (European Representative on Council, 2015-), The Society for Reproductive Investigation, and The Fetal and Neonatal Physiological Society. Dr Green is an Editorial Board member for Physiological Reports (Wiley).

Qualifications

BSc. (Hons.), Physiology, University of London (1991)
Ph.D., University of London (1996)

Appointments held

1998-2000 Lecturer, Department of Obstetrics and Gynaecology, University College London, U.K.
2000-2005 Lecturer, School of Medicine, University of Southampton, UK
2005-2008 Senior Lecturer, School of Medicine, University of Southampton, UK
2008-present Reader, School of Medicine, University of Southampton, UK

Research

Responsibilities

Publications

Teaching

Contact

Research interests

Research Interests

Dr Green’s research concerns the mechanisms underlying the effect of the early nutritional environment on cardiovascular development, growth and metabolism during fetal and postnatal life. This has potential ramifications for increased risk of diseases in later life.

Research Projects

Fetal cardiovascular adaptive responses in a non-optimal nutritional environment

Models determining the nature of fetal adaptations (and the underlying mechanisms) to changes in nutrients during pregnancy, such as restriction of calorific intake or depletion of vitamin D. We compare and translate these findings to fetal cardiovascular measurements from ongoing human clinical trials in Southampton (e.g. Southampton Women’s Survey, SPRING).

Postnatal consequences for skeletal muscle of a prenatal and postnatal obesity

Using models of obesity from conception and throughout the life course to study the impact on offspring skeletal muscle structure and contractile function. Cross-faculty collaboration with researchers from The Institute for Developmental Sciences (Faculty of Medicine), The Centre for Biological Sciences (Faculty of Natural and Environmental Sciences) and The Institute of Sound and Vibration Research (Faculty of Engineering and the Environment).

Reduced pregnancy vitamin D and offspring skeletal muscle

We have established models for vitamin D depletion in pregnancy to examine the mechanistic link between reduced vitamin D in early development and skeletal muscle development and adult function. Cross-faculty collaboration with researchers from The Institute for Developmental Sciences, The Centre for Biological Sciences and The Institute of Sound and Vibration Research.

Relationship between sunlight, diet and vitamin D across ethnic groups

Collaboration on a Malaysian Cohort grant (FRGS) with Chong and Khor (IMU, Malaysia).

Laboratory in utero validation of non-invasive fetal ECG monitoring
Translational science

Academic unit(s)

Human Development and Health Academic Units

Affiliate academic unit(s)

Human development and physiology Research group

Postgraduate student supervision

Awarded
2004 Christopher Torrens Ph.D.
2006 Jane Cleal Ph.D.
2006 Deborah Burrage Ph.D.
2007 Lucinda Braddick Ph.D.
2009 Paula Costello Ph.D.

Current
Lisa Jones Ph.D.
Lisa Hollis Ph.D.
Katy Gould Ph.D.

Faculty of Medicine

  • Head of Field for Maternal, Fetal and Neonatal Physiology (BMedSc. student projects)
  • Co-leader of Mother, Pregnancy and Child theme (Human Development and Health (HDH) Academic Unit)
  • HDH executive group member
  • HDH Education Committee member
  • Board Member, MMedSc programme

University of Southampton

Member of Senate (2011-2013)

National and International responsibilities

  • Fetal and Neonatal Research Society, Board Member (2008-present)
  • International Union of Physiological Sciences 2013 (Birmingham, UK) International and Local Organizing Committees member (2010-2013)
  • Member of The Physiological Society, Society for Gynecologic Investigation, DOHaD Society, Blair Bell Research Society, Fetal and Neonatal Physiological Society
  • Editorial board, Physiological Reports

Articles

Book

Book Chapters

    Green, L. R., Hanson, M. A., & Oepkes, D. (2012). Insights into pathogenesis of adult cardiovascular disease from fetal animal studies. In M. D. Kilby, & A. Johnson (Eds.), Fetal Therapy: Scientific Basis and Critical Appraisal of Clinical Benefits. (pp. 12-23). Cambridge, GB: Cambridge University Press.
    Green, L. R., & Hanson, M. A. (2011). Developmental effects on fetal circulation. In R. A. Polin, W. W. Fox, & S. H. Abman (Eds.), Fetal and Neonatal Physiology. 4th Edition. (pp. 798-806). Philadelphia, US: Saunders.
    Newman, J. P., Hanson, M. A., & Green, L. R. (2003). Fetal adaptations to hypoxia. In S. Lahiri, G. L. Semenza, & N. R. Prabhakar (Eds.), Oxygen Sensing: Responses and Adaptation to Hypoxia. (pp. 209-234). (Lung Biology in Health and Disease; No. 175). New York, US: Marcel Dekker.

Conferences

Pastoral care

  • Personal tutor (BM5)
  • Postgraduate mentoring

Undergraduate teaching

1) Maternal, Fetal and Neonatal Physiology (BIOL3044 / BIOL6040)

For year 3 or Masters basic science (FNES) and MMedSc students. This course focuses on exciting new developments in the fields of embryonic, placental and fetal physiology, and life after birth using the Developmental Origins of Health and Disease (DOHaD) hypothesis as a conceptual framework upon which to base learning. Dr Green’s role in the course is as course organizer, facilitator and lecturer.

2) BMedSc / MMedSc

Outreach activities

Many non-communicable diseases may have a developmental origin
TheDOHaD hypothesis:
Dr Lucy Green
Faculty of Medicine University of Southampton Southampton General Hospital Mailpoint 887 Institute of Developmental Sciences Building Tremona Road Southampton SO16 6YD

Room Number:SGH/IDS B07/MP887

Telephone:(023) 8120 6373
Facsimile:(023) 8120 5255
Email:L.R.Green@soton.ac.uk

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