The University of Southampton

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Phone:: (023) 8120 6373
Email:: L.R.Green@soton.ac.uk

Dr Lucy Green BSc, PhD

Associate Professor in Developmental Physiology

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My research uncovers the adaptive responses made by the fetus to changes in nutrition in pregnancy, which have implications for health of skeletal muscle and the cardiovascular system in later life. I am an Associate Professor in Developmental Physiology in the Faculty of Medicine.

It seems that it isn’t just about adult diet and lifestyle – your health may have been determined when you were just a twinkle in your mother’s eye

Dr Lucy Green joined the Faculty of Medicine in 2000 and is based in The Institute of Developmental Sciences (Southampton General Hospital). Her work is part of a strong Faculty theme on the Developmental Origins of Health and Disease. She held a previous academic appointment at University College London (1998-2000) and trained at King’s College London, Cornell University (USA), University College London, and University of Western Ontario (Canada).

She is a member of The Physiological Society, The International Society for Developmental Origins of Health and Disease (European Representative on Council, 2015-), The Society for Reproductive Investigation, and The Fetal and Neonatal Physiological Society. Dr Green is an Editorial Board member for Physiological Reports (Wiley).

Qualifications

BSc. (Hons.), Physiology, University of London (1991)
Ph.D., University of London (1996)

Appointments held

1998-2000 Lecturer, Department of Obstetrics and Gynaecology, University College London, U.K.
2000-2005 Lecturer, School of Medicine, University of Southampton, UK
2005-2008 Senior Lecturer, School of Medicine, University of Southampton, UK
2008-present Reader, School of Medicine, University of Southampton, UK

Research

Responsibilities

Publications

Teaching

Contact

Research interests

Research Interests

Dr Green’s research concerns the mechanisms underlying the effect of the early nutritional environment on cardiovascular development, growth and metabolism during fetal and postnatal life. This has potential ramifications for increased risk of diseases in later life.

Research Projects

Fetal cardiovascular adaptive responses in a non-optimal nutritional environment

Models determining the nature of fetal adaptations (and the underlying mechanisms) to changes in nutrients during pregnancy, such as restriction of calorific intake or depletion of vitamin D. We compare and translate these findings to fetal cardiovascular measurements from ongoing human clinical trials in Southampton (e.g. Southampton Women’s Survey, SPRING).

Postnatal consequences for skeletal muscle of a prenatal and postnatal obesity

Using models of obesity from conception and throughout the life course to study the impact on offspring skeletal muscle structure and contractile function. Cross-faculty collaboration with researchers from The Institute for Developmental Sciences (Faculty of Medicine), The Centre for Biological Sciences (Faculty of Natural and Environmental Sciences) and The Institute of Sound and Vibration Research (Faculty of Engineering and the Environment).

Reduced pregnancy vitamin D and offspring skeletal muscle

We have established models for vitamin D depletion in pregnancy to examine the mechanistic link between reduced vitamin D in early development and skeletal muscle development and adult function. Cross-faculty collaboration with researchers from The Institute for Developmental Sciences, The Centre for Biological Sciences and The Institute of Sound and Vibration Research.

Relationship between sunlight, diet and vitamin D across ethnic groups

Collaboration on a Malaysian Cohort grant (FRGS) with Chong and Khor (IMU, Malaysia).

Laboratory in utero validation of non-invasive fetal ECG monitoring — Translational science

Academic unit(s)

Human Development and Health Academic Units

Affiliate academic unit(s)

Human development and physiology Research group

Postgraduate student supervision

Awarded
2004 Christopher Torrens Ph.D.
2006 Jane Cleal Ph.D.
2006 Deborah Burrage Ph.D.
2007 Lucinda Braddick Ph.D.
2009 Paula Costello Ph.D.

Current
Lisa Jones Ph.D.
Lisa Hollis Ph.D.
Katy Gould Ph.D.

Faculty of Medicine

Head of Field for Maternal, Fetal and Neonatal Physiology (BMedSc. student projects)
Co-leader of Mother, Pregnancy and Child theme (Human Development and Health (HDH) Academic Unit)
HDH executive group member
HDH Education Committee member
Board Member, MMedSc programme

University of Southampton

Member of Senate (2011-2013)

National and International responsibilities

Fetal and Neonatal Research Society, Board Member (2008-present)
International Union of Physiological Sciences 2013 (Birmingham, UK) International and Local Organizing Committees member (2010-2013)
Member of The Physiological Society, Society for Gynecologic Investigation, DOHaD Society, Blair Bell Research Society, Fetal and Neonatal Physiological Society
Editorial board, Physiological Reports

Articles

EFSA Panel on Animal Health and Welfare (AHAW) (2017). Animal welfare aspects in respect of the slaughter or killing of pregnant livestock animals (cattle, pigs, sheep, goats, horses). EFSA Journal, 15(5), [4782]. DOI: 10.2903/j.efsa.2017.4782
Cleal, J., Hargreaves, M., Poore, K., Tang, J., Fraser, W., Hanson, M., & Green, L. (2017). Reduced fetal vitamin D status by maternal undernutrition during discrete gestational windows in sheep. Journal of Developmental Origins of Health and Disease, 8(3), 370-381. [DOHaD-11-16-OA-0735]. DOI: 10.1017/S2040174417000149
Poore, K. R., Hollis, L. J., Murray, R. J. S., Warlow, A., Brewin, A., Fulford, L., ... Green, L. R. (2014). Differential pathways to adult metabolic dysfunction following poor nutrition at two critical developmental periods in sheep. PLoS ONE, 9(3), 1-13. DOI: 10.1371/journal.pone.0090994
Cleal, J. K., Thomas, M., Hanson, M. A., Paterson-Brown, S., Gardiner, H. M., & Green, L. R. (2010). Noninvasive fetal electrocardiography following intermittent umbilical cord occlusion in the preterm ovine fetus. BJOG: An International Journal of Obstetrics & Gynaecology, 117(4), 438-444. DOI: 10.1111/j.1471-0528.2009.02471.x
Poore, K. R., Boullin, J. P., Cleal, J. K., Newman, J. P., Noakes, D. E., Hanson, M. A., & Green, L. R. (2010). Sex- and age-specific effects of nutrition in early gestation and early postnatal life on hypothalamo-pituitary-adrenal axis and sympathoadrenal function in adult sheep. Journal of Physiology, 588(12), 2219-2237. DOI: 10.1113/jphysiol.2010.187682
Cleal, J. K., Bagby, S., Hanson, M. A., Gardiner, H., & Green, L. (2010). The effect of late gestation fetal hypoglycaemia on cardiovascular and endocrine function in sheep. Journal of Developmental Origins of Health and Disease, 1(1), 42-49. DOI: 10.1017/S204017440999016X
Torrens, C., Snelling, T. H., Chau, R., Shanmuganathan, M., Cleal, J. K., Poore, K. R., ... Green, L. R. (2009). Effects of pre- and periconceptional undernutrition on arterial function in adult female sheep are vascular bed dependent. Experimental Physiology, 94(9), 1024-1033. DOI: 10.1113/expphysiol.2009.047340
Burrage, D. M., Braddick, L., Cleal, J. K., Costello, P., Noakes, D. E., Hanson, M. A., & Green, L. R. (2009). The late gestation fetal cardiovascular response to hypoglycaemia is modified by prior peri-implantation undernutrition in sheep. Journal of Physiology, 587(3), 611-624. DOI: 10.1113/jphysiol.2008.165944
Pollintine, P., Barrett, G. W., Millais, I. E., Green, L. R., Cooper, C., Lanham, S. A., ... Dolan, P. (2008). Early nutritional compromise affects the mechanical properties of sheep spines. Journal of Bone and Joint Surgery, 90B(Supplement 2), 373-374.
Costello, P. M., Cripps, R. L., Bearpark, N., Rowlerson, A., Hollis, L., Patel, H., ... Green, L. R. (2008). Effect of maternal diet and body condition on glucose metabolism and skeletal muscle structure in mature adult sheep offspring. Proceedings of the Physiological Society, 11(C32).
Costello, P. M., Rowlerson, A., Astaman, N. A., Anthony, F. E. W., Sayer, A. A., Cooper, C., ... Green, L. R. (2008). Peri-implantation and late gestation maternal undernutrition differentially affect fetal sheep skeletal muscle development. Journal of Physiology, 586(9), 2371-2379. DOI: 10.1113/jphysiol.2008.150987
Burrage, D., Green, L. R., Moss, T. J., Sloboda, D. M., Nitsos, I., Newnham, J. P., & Hanson, M. A. (2008). The carotid bodies influence growth responses to moderate maternal undernutrition in late-gestation fetal sheep. BJOG: An International Journal of Obstetrics & Gynaecology, 115(2), 261-268. DOI: 10.1111/j.1471-0528.2007.01607.x
Cripps, R. L., Green, L. R., Thompson, J., Martin-Gronert, M. S., Monk, M., Sheldon, I. M., ... Ozanne, S. E. (2008). The effect of maternal body condition score before and during pregnancy on the glucose tolerance of adult sheep offspring. Reproductive Sciences, 15(5), 448-456. DOI: 10.1177/1933719107312161
Pollintine, P., Cooper, I., Anderson, H. L., Green, L. R., Cooper, C., Lanham, S. A., ... Dolan, P. (2008). The influence of early nutritional compromise on bone structure and strength. Journal of Bone and Joint Surgery, 90-B(Supp II), p.392.
Costello, P. M., Braddick, L., Burrage, D., Hanson, M. A., & Green, L. R. (2007). Circulating glucose affects vascular reactivity in late gestation sheep fetuses. Early Human Development, 82(8), 518-519. DOI: 10.1016/j.earlhumdev.2006.06.003
Costello, P., Rowlerson, A., Braddick, L., Burrage, D., Cooper, C., Ahie Sayer, A., ... Green, L. R. (2007). Fetal skeletal muscle capillary density is reduced by both early and late gestation maternal undernutrition in sheep. Proceedings of the Physiological Society, 6, PC2-PC2.
Hollis, L., Anthony, F. W., Hanson, M. A., & Green, L. R. (2007). Hepatic glucocorticoid receptor expression in adult sheep following early gestational and / or postnatal undernutrition. Proceedings of the Physiological Society, 6(PC4).
Cleal, J. K., Poore, K. R., Boullin, J. P., Khan, O., Chau, R., Hambidge, O., ... Green, L. R. (2007). Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood. Proceedings of the National Academy of Sciences of the United States of America, 104(22), 9529-9533. DOI: 10.1073/pnas.0610373104
Poore, K. R., Cleal, J. K., Newman, J. P., Boullin, J. P., Noakes, D. E., Hanson, M. A., & Green, L. R. (2007). Nutritional challenges during development induce sex-specific changes in glucose homeostasis in the adult sheep. American Journal of Physiology: Endocrinology and Metabolism, 292(1), E32-E39. DOI: 10.1152/ajpendo.00253.2006
Costello, P. M., Astaman, N. A., Anthony, F. W., Sayer, A. A., Cooper, C., Hanson, M. A., & Green, L. R. (2007). Peri-implantation and late gestation maternal undernutrition differentially alter pathways of insulin and IGF-1 action in fetal sheep skeletal muscle. Early Human Development, 83(Supplement 1), pp.S135. DOI: 10.1016/S0378-3782(07)70356-0
Cleal, J. K., Hanson, M. A., Gardiner, H. M., & Green, L. R. (2007). The effect of acute maternal hypoglycaemia on fetal cardiovascular control. Early Human Development, 83(supplement 1), p.S88. DOI: 10.1016/S0378-3782(07)70191-3
Cleal, J. K., Poore, K. R., Newman, J. P., Noakes, D. E., Hanson, M. A., & Green, L. R. (2007). The effect of maternal undernutrition in early gestation on gestation length and fetal and postnatal growth in sheep. Pediatric Research, 62(4), 422-427.
Braddick, L., Burrage, D., Cleal, J., Noakes, D., Hanson, M. A., & Green, L. R. (2007). The effect of moderate early gestation undernutrition on kidney glomerular number in fetal sheep. Proceedings of the Physiological Society, 6(PC3).
Khan, O. A., Chau, R., Torrens, C., Cleal, J., Anthony, F., Ohri, S. K., ... Green, L. R. (2006). Early gestation undernutrition causes increased expression of myosin light chain kinase in adult sheep coronary arteries [In special abstracts issue]. Early Human Development, 82(8), p.499. DOI: 10.1016/j.earlhumdev.2006.06.003
Costello, P., Rowlerson, A., Braddick, L., Burrage, D., Cooper, C., Hanson, M. A., ... Green, L. R. (2006). Fetal skeletal muscle fibre number and type are altered by early and late gestation matetrnal undernutrition in sheep. Procedings of the Physiological Society, 3(C116).
Braddick, L., Burrage, D., Cleal, J., Noakes, D., Hanson, M. A., & Green, L. R. (2006). Moderate early gestation undernutrition has no effect on kidney size and function in late gestation. Journal of the Society for Gynecologic Investigation, 13(2).
Chau, R., Torrens, C., Ohri, S. K., Noakes, D. E., Poston, L., Hanson, M. A., & Green, L. R. (2006). Pre- and periconceptional nutrient restriction affect coronary vascular reactivity in sheep offspring [In special abstracts issue]. Early Human Development, 82(8), p.524. DOI: 10.1016/j.earlhumdev.2006.06.003
Pound, J. C., Green, D. W., Chaudhuri, J. B., Mann, S., Roach, H. I., & Oreffo, R. O. C. (2006). Strategies to promote chondrogenesis and osteogenesis from human bone marrow cells and articular chondrocytes encapsulated in polysaccharide templates. Tissue Engineering, 12(10), 2789-2799. DOI: 10.1089/ten.2006.12.2789
Yang, X. B., Green, D. W., Roach, H. I., Anderson, H. C., Howdle, S. M., Shakesheff, K. M., & Oreffo, R. O. C. (2006). The effect of an admix of bone morphogenetic proteins on human osteoprogenitor activity in vitro and in vivo. Tissue Engineering, 12(4), 1002-1003. DOI: 10.1089/ten.2006.12.983
Khan, O. A., Torrens, C., Noakes, D. E., Poston, L., Hanson, M. A., Green, L. R., & Ohri, S. K. (2005). Effects of pre-natal and early post-natal undernutrition on adult internal thoracic artery function. European Journal of Cardio-Thoracic Surgery, 28(6), 811-815. DOI: 10.1016/j.ejcts.2005.08.021
Elmes, M., Green, L. R., Poore, K., Newman, J., Burrage, D., Abayasekara, D. R. E., ... Wathes, D. C. (2005). Raised dietary n-6 polyunsaturated fatty acid intake increases 2-series prostaglandin production during labour in the ewe. Journal of Physiology, 562(2), 583-592. DOI: 10.1113/jphysiol.2004.071969
Gallagher, E. A. L., Newman, J. P., Green, L. R., & Hanson, M. A. (2005). The effect of low protein diet in pregnancy on the development of brain metabolism in rat offspring. Journal of Physiology, 568(2), 553-558. DOI: 10.1113/jphysiol.2005.092825
Nardo, L., Zhao, L., Green, L. R., Possmayer, F., Richardson, B. S., & Bocking, A. D. (2005). The effect of repeated umbilical cord occlusions on pulmonary surfactant protein mRNA levels in the ovine fetus. Journal of the Society for Gynecologic Investigation, 12(7), 510-517. DOI: 10.1016/j.jsgi.2005.07.004
Nishina, H., Green, L. R., McGarrigle, H. H. G., Noakes, D. E., Poston, L., & Hanson, M. A. (2003). Effect of nutritional restriction in early pregnancy on isolated femoral artery function in mid-gestation fetal sheep. Journal of Physiology, 553(2), 637-647. DOI: 10.1113/jphysiol.2003.045278
Miller, S. L., Green, L. R., Peebles, D. M., Hanson, M. A., & Blanco, C. E. (2002). Effects of chronic hypoxia and protein malnutrition on growth in the developing chick. American Journal of Obstetrics and Gynecology, 186(2), 261-267. DOI: 10.1067/mob.2002.119629
Green, L. R., Kawagoe, Y., Homan, J., White, S. E., & Richardson, B. S. (2001). Adaptation of cardiovascular responses to repetitive umbilical cord occlusion in the late gestation ovine fetus. Journal of Physiology, 535(3), 879-888. DOI: 10.1111/j.1469-7793.2001.t01-1-00879.x
Czikk, M. J., Green, L. R., Kawagoe, Y., McDonald, T. J., Hill, D. J., & Richardson, B. S. (2001). Intermittent umbilical cord occlusion in the ovine fetus: effects on blood glucose, insulin, and glucagon and on pancreatic development. Journal of the Society for Gynecologic Investigation, 8(4), 191-197. DOI: 10.1016/S1071-5576(01)00114-9
Kalache, K. D., Ojutiku, D., Nishina, H., Green, L. R., & Hanson, M. A. (2001). Mild maternal undernutrition in the first half of ovine pregnancy influences placental morphology but not fetal Doppler flow velocity waveforms and fetal heart size. Journal of Perinatal Medicine, 29(4), 286-292. DOI: 10.1515/JPM.2001.041

Book

Green, L., & Hester, R. (Eds.) (2016). Parental obesity: intergenerational programming and consequences. (Physiology in Health and Disease). New York, US: Springer. DOI: 10.1007/978-1-4939-6386-7

Book Chapters

Green, L. R., Hanson, M. A., & Oepkes, D. (2012). Insights into pathogenesis of adult cardiovascular disease from fetal animal studies. In M. D. Kilby, & A. Johnson (Eds.), Fetal Therapy: Scientific Basis and Critical Appraisal of Clinical Benefits (pp. 12-23). Cambridge, GB: Cambridge University Press.
Green, L. R., & Hanson, M. A. (2011). Developmental effects on fetal circulation. In R. A. Polin, W. W. Fox, & S. H. Abman (Eds.), Fetal and Neonatal Physiology. 4th Edition (pp. 798-806). Philadelphia, US: Saunders.
Newman, J. P., Hanson, M. A., & Green, L. R. (2003). Fetal adaptations to hypoxia. In S. Lahiri, G. L. Semenza, & N. R. Prabhakar (Eds.), Oxygen Sensing: Responses and Adaptation to Hypoxia (pp. 209-234). (Lung Biology in Health and Disease; No. 175). New York, US: Marcel Dekker.

Conferences

Poore, K. R., Cleal, J. K., Newman, J. P., Boullin, J., Hanson, M. A., & Green, L. R. (2008). The effect of growth in early life on metabolic homeostasis in later life. In S. Wilsher, J. F. Wade, & W. R. Allen (Eds.), Proceedings of a Workshop on Second Workshop Embryonic and Fetal Nutrition (pp. 81-86). (Havemeyer Foundation Monograph Series; No. 21). Newmarket, United Kingdom: R & W Communications.
Poore, K. R., Cleal, J. K., Newman, J. P., Boullin, J., Noakes, D., Hanson, M. A., & Green, L. R. (2006). Hypothalamo-pituitary-adrenal axis responsiveness in adult sheep following early life nutrient restriction. Early Human Development, 82(8), pp.537.
Cleal, J. K., Thomas, M., Smith, M. J., Hanson, M. A., Gardiner, H. M., & Green, L. R. (2006). Non-invasive measures of heart rate variability following intermittent umbilical cord occlusion in the preterm ovine fetus. Paper presented at Measurement & Modelling of Autonomic Function, .
Cleal, J. K., Poore, K. R., Newman, J. P., Noakes, D., Hanson, M. A., & Green, L. R. (2006). Sex and twinning influence early gestation undernutrition effects on sheep offspring growth. Early Human Development, 82(8), p.550.

Pastoral care

Personal tutor (BM5)
Postgraduate mentoring

Undergraduate teaching

1) Maternal, Fetal and Neonatal Physiology (BIOL3044 / BIOL6040)

For year 3 or Masters basic science (FNES) and MMedSc students. This course focuses on exciting new developments in the fields of embryonic, placental and fetal physiology, and life after birth using the Developmental Origins of Health and Disease (DOHaD) hypothesis as a conceptual framework upon which to base learning. Dr Green’s role in the course is as course organizer, facilitator and lecturer.

2) BMedSc / MMedSc

Research project supervisor since 2000. For further details see (https://www.som.soton.ac.uk/learn/bm/yr4/project/fieldguide/guides/)
MMedSc journal club facilitator.

Outreach activities

Student mentor - Physiological Society competition for school children “The Science of Life: How your body works”
Cafe Scientific meeting (29.4.13) (http://www.cafesci-basingstoke.org.uk/) (question and answer session with Prof M Hanson)

TheDOHaD hypothesis:

Dr Lucy Green
Faculty of Medicine University of Southampton Southampton General Hospital Mailpoint 887 Institute of Developmental Sciences Building Tremona Road Southampton SO16 6YD

Room Number:SGH/IDS B07/MP887

Telephone:(023) 8120 6373
Facsimile:(023) 8120 5255
Email:L.R.Green@soton.ac.uk

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