Cosma Mirella Spalluto

Publications

35 publications

Page 1 of 4

Synthetic heparan sulfate mimetic pixatimod (PG545) potently inhibits SARS-CoV-2 by disrupting the Spike-ACE2 interaction

Scott E Guimond,

Courtney J Mycroft-West,

Neha S Gandhi,

Julia A Tree,

Thuy T Le,

C Mirella Spalluto,

Maria V Humbert,

Karen R Buttigieg,

Naomi Coombes,

Michael J Elmore,

Matthew Wand,

Kristina Nyström,

Joanna Said,

Yin Xiang Setoh,

Alberto A Amarilla,

Naphak Modhiran,

Julian D J Sng,

Mohit Chhabra,

Paul R Young,

Daniel J Rawle,

Marcelo A Lima,

Edwin A Yates,

Richard Karlsson,

Rebecca L Miller,

Yen-Hsi Chen,

Ieva Bagdonaite,

Zhang Yang,

James Stewart,

Dung Nguyen,

Stephen Laidlaw,

Edward Hammond,

Keith Dredge,

Tom M A Wilkinson,

Daniel Watterson,

Alexander A Khromykh,

Andreas Suhrbier,

Miles W Carroll,

Edward Trybala,

Tomas Bergström,

Vito Ferro,

Mark A Skidmore,

& Jeremy E Turnbull

, 2022 , ACS Central Science , 8 (5) , 527--545

DOI: 10.1021/acscentsci.1c01293

Type: article

Towards an artificial human lung

Maria Victoria Humbert,

Cosma Mirella Spalluto,

Joseph Bell,

Cornelia Blume,

Franco Conforti,

Elizabeth R Davies,

Lareb S N Dean,

Paul Elkington,

Hans Michael Haitchi,

Claire Jackson,

Mark G Jones,

Matthew Loxham,

Jane S Lucas,

Hywel Morgan,

Marta Polak,

Karl J Staples,

Emily J Swindle,

Liku Tezera,

Alastair Watson,

& Tom M A Wilkinson

, 2022 , European Respiratory Journal , 60 (2)

DOI: 10.1183/13993003.00455-2022

Type: article

Exercise training induces a shift in extracellular redox status with alterations in the pulmonary and systemic redox landscape in asthma

Anna Freeman,

Doriana Cellura,

Magdalena Minnion,

Bernadette Fernandez,

C. Mirella Spalluto,

Denny Levett,

Andrew Bates,

Timothy Wallis,

Alastair Watson,

Sandra Jack,

Karl J. Staples,

Mike P. Grocott,

Martin Feelisch,

& Tom M.A. Wilkinson

, 2021 , Antioxidants , 10 (12)

DOI: 10.3390/antiox10121926

Type: article

Dysregulation of COVID-19 related gene expression in the COPD lung

Alastair Watson,

Lisa Oberg,

Bastian Angermann,

C. Mirella Spalluto,

Michael Huhn,

Hannah Burke,

Doriana Cellura,

Anna Freeman,

Daniel Muthas,

Damla Etal,

Graham Belfield,

Fredrik Karlsson,

Karl Nordstrom,

Kristoffer Ostridge,

Karl J. Staples,

& Thomas Wilkinson

, 2021 , Respiratory Research , 22 (1) , 164

DOI: 10.1186/s12931-021-01755-3

Type: article

Influence of hypoxia on the epithelial-pathogen interactions in the lung: implications for respiratory disease

Lee K. Page,

Karl J. Staples,

C. Mirella Spalluto,

Alastair Watson,

& Thomas Wilkinson

, 2021 , Frontiers in Immunology , 12

DOI: 10.3389/fimmu.2021.653969

Type: article

A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection

Cornelia Blume,

Claire Jackson,

Cosma Spalluto,

Jelmer Legebeke,

Liliya Nazlamova,

Franco Conforti,

Jeanne-Marie Perotin-Collard,

Martin Frank,

John Butler,

Max Crispin,

Janice Coles,

James Thompson,

Robert Ridley,

Lareb Dean,

Matthew Loxham,

Stephanie Reikine,

Adnan Azim,

Kamran Tariq,

David Johnston,

Paul James Stuart Skipp,

Ratko Djukanovic,

Diana Baralle,

Christopher Mccormick,

Donna Davies,

Jane Lucas,

Gabrielle Wheway,

& Vito Mennella

, 2021 , Nature Genetics , 53 (2) , 205–214

DOI: 10.1101/2020.07.31.230870

Type: article

Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations

Julia A. Tree,

Jeremy E. Turnbull,

Karen R. Buttigieg,

Michael J. Elmore,

Naomi Coombes,

John Hogwood,

Courtney J. Mycroft-West,

Marcelo A. Lima,

Mark A. Skidmore,

Richard Karlsson,

Yen-Hsi Chen,

Yang Zhang,

Cosma Mirella Spalluto,

Karl J. Staples,

Edwin A. Yates,

Elaine Gray,

Dave Singh,

Tom Wilkinson,

Clive P. Page,

& Miles W. Carroll

, 2021 , British Journal of Pharmacology , 178 (3) , 626--635

DOI: 10.1111/bph.15304

Type: article

The role of extracellular vesicles as a shared disease mechanism contributing to multimorbidity in patients with COPD

Laura V. Reid,

C. Mirella Spalluto,

Alastair Watson,

Karl J. Staples,

& Tom M.A. Wilkinson

, 2021 , Frontiers in Immunology , 12

DOI: 10.3389/fimmu.2021.754004

Type: article

The role of non-typeable Haemophilus influenzae biofilms in Chronic Obstructive Pulmonary Disease

Jake R Weeks,

Karl J. Staples,

C. Mirella Spalluto,

Alastair Watson,

& Tom M. Wilkinson

, 2021 , Frontiers in Cellular and Infection Microbiology , 11

DOI: 10.3389/fcimb.2021.720742

Type: review

Interrelationships among small airways dysfunction, neutrophilic inflammation, and exacerbation frequency in COPD

Kerry Day,

Kristoffer Ostridge,

Joy Conway,

Doriana Cellura,

Alastair Watson,

Cosma Mirella Spalluto,

Karl J Staples,

Bruce Thompson,

& Tom Wilkinson

, 2021 , Chest , 159 (4) , 1391--1399

DOI: 10.1016/j.chest.2020.11.018

Type: article

Doctor Cosma Mirella Spalluto

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