Prof R. Read: MRC Experimental Human Challenge with Genetically Modified Commensals to Investigate Respiratory Tract Mucosal Immunity and Colonisation

Staff

Lead researchers

Professor Robert Read

Chair of Infectious Diseases

Connect with Robert

Email: R.C.Read@soton.ac.uk

Other researchers

Emeritus Professor Ian Clarke

Research interests

Transposon mutagenesis of Chlamydia species
Cell culture systems and replicons for human noroviruses

Connect with Ian

Email: inc@soton.ac.uk

Professor Saul Faust MBBS, FRCPCH, PhD, FHEA, OBE

Professor Paediatric Immunology & Infect

Connect with Saul

Email: s.faust@soton.ac.uk

Research outputs

Effect of priming interval on reactogenicity, peak immunological response, and waning after homologous and heterologous COVID-19 vaccine schedules: exploratory analyses of Com-COV, a randomised control trial

Robert H. Shaw, Xinxue Liu, Arabella S.V. Stuart, Melanie Greenland, Parvinder K. Aley, Nick J. Andrews, Saul Faust & Robert Read, 2022, The Lancet Respiratory Medicine, 10(11), 1049-1060

DOI: 10.1016/S2213-2600(22)00163-1

Type: article

Antibiotics for lower respiratory tract infection in children presenting in primary care (ARTIC-PC): the predictive value of molecular testing

Paul Little, Robert C. Read, Taeko Becque, Nick A. Francis, Alastair D. Hay, Beth Stuart, Gilly O'Reilly, Natalie Thompson, Kerenza Hood, Saul Faust, Kay Wang, Michael Moore & Theo Verheij, 2022, Clinical Microbiology and Infection, 28(9), 1238-1244

DOI: 10.1016/j.cmi.2022.02.033

Type: article

Safety, immunogenicity, and reactogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines given as fourth-dose boosters following two doses of ChAdOx1 nCoV-19 or BNT162b2 and a third dose of BNT162b2 (COV-BOOST): a multicentre, blinded, phase 2, randomised trial

Alasdair P S Munro, Shuo Feng, Leila Janani, Victoria Cornelius, Parvinder K Aley, Gavin Babbage, David Baxter, Marcin Bula, Katrina Cathie, Krishna Chatterjee, Kate Dodd, Yvanne Enever, Ehsaan Qureshi, Anna L Goodman, Christopher A Green, Linda Harndahl, John Haughney, Alexander Hicks, Agatha A van der Klaauw, Nasir Kanji, Vincenzo Libri, Martin J Llewelyn, Alastair C McGregor, Mina Maallah, Angela M Minassian, Patrick Moore, Mehmood Mughal, Yama F Mujadidi, Kyra Holliday, Orod Osanlou, Rostam Osanlou, Daniel R Owens, Mihaela Pacurar, Adrian Palfreeman, Daniel Pan, Tommy Rampling, Karen Regan, Stephen Saich, Tanveer Bawa, Dinesh Saralaya, Sunil Sharma, Ray Sheridan, Emma C Thomson, Shirley Todd, Chris Twelves, Robert C Read, Sue Charlton, Bassam Hallis, Mary Ramsay & Saul N Faust, 2022, The Lancet Infectious Diseases, 22(8), 1131-1141

DOI: 10.1016/S1473-3099(22)00271-7

Type: article

Persistence of immunogenicity after seven COVID-19 vaccines given as third dose boosters following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK: three month analyses of the COV-BOOST trial

Xinxue Liu, Alasdair P S Munro, Shuo Feng, Leila Janani, Parvinder K Aley, Gavin Babbage, David Baxter, Marcin Bula, Katrina Cathie, Krishna Chatterjee, Wanwisa Dejnirattisai, Kate Dodd, Yvanne Enever, Ehsaan Qureshi, Anna L Goodman, Christopher A Green, Linda Harndahl, John Haughney, Alexander Hicks, Agatha A van der Klaauw, Jonathan Kwok, Vincenzo Libri, Martin J Llewelyn, Alastair C McGregor, Angela M Minassian, Patrick Moore, Mehmood Mughal, Yama F Mujadidi, Kyra Holliday, Orod Osanlou, Rostam Osanlou, Daniel R Owens, Mihaela Pacurar, Adrian Palfreeman, Daniel Pan, Tommy Rampling, Karen Regan, Stephen Saich, Teona Serafimova, Dinesh Saralaya, Gavin R Screaton, Sunil Sharma, Ray Sheridan, Ann Sturdy, Piyada Supasa, Emma C Thomson, Shirley Todd, Chris Twelves, Robert C Read & Saul N Faust, 2022, Journal of Infection, 84(6), 795-813

DOI: 10.1016/j.jinf.2022.04.018

Type: article

Controlled human infection with Neisseria lactamica in late pregnancy to measure horizontal transmission and microbiome changes in mother-neonate pairs

Anastasia A Theodosiou, Jay R Laver, Adam P Dale, David W Cleary, Christine E Jones & Robert C Read, 2022, BMJ Open, 12(5)

DOI: 10.1136/bmjopen-2021-056081

Type: article

Public attitudes to a human challenge study with SARS-CoV-2: a mixed-methods study

Caroline Barker, Katharine Collet, Diane Gbesemete, Maria Piggin, Daniella Watson, Philippa Pristerà, Wendy Lawrence, Emma Smith, Michael Bahrami-Hessari, Halle Johnson, Katherine Baker, Ambar Qavi, Carmel McGrath, Christopher Chiu, Robert C Read & Helen Ward, 2022, Wellcome Open Research , 7, 49

DOI: 10.12688/wellcomeopenres.17516.1

Type: article

Immunogenicity, safety, and reactogenicity of heterologous COVID-19 primary vaccination incorporating mRNA, viral-vector, and protein-adjuvant vaccines in the UK (Com-COV2): a single-blind, randomised, phase 2, non-inferiority trial

Arabella S V Stuart, Robert H Shaw, Xinxue Liu, Melanie Greenland, Parvinder K Aley, Nick J Andrews, J C Cameron, Sue Charlton, Elizabeth A Clutterbuck, Andrea M Collins, Tom Darton, Tanya Dinesh, Christopher J A Duncan, Anna England, Saul N Faust, Daniela M Ferreira, Adam Finn, Anna L Goodman, Christopher A Green, Bassam Hallis, Paul T Heath, Helen Hill, Bryn M Horsington, Teresa Lambe, Rajeka Lazarus, Vincenzo Libri, Patrick J Lillie, Yama F Mujadidi, Ruth Payne, Emma L Plested, Samuel Provstgaard-Morys, Maheshi N Ramasamy, Mary Ramsay, Robert C Read, Hannah Robinson, Gavin R Screaton, Nisha Singh, David P J Turner, Paul J Turner, Iason Vichos, Rachel White, Jonathan S Nguyen-Van-Tam & Matthew D Snape, 2022, The Lancet, 399(10319), 36-49

DOI: 10.1016/S0140-6736(21)02718-5

Type: article