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The University of Southampton
Centre for Human Development, Stem Cells and Regeneration

Dr Sylvia Pender

Gingival derived cells
Gingival derived cells

Research in Sylvia Pender’s laboratory focuses on the functions of matrix metalloproteinases (MMPs) in system biology.  Due to their ability to cleave, degrade and rearrange extra-cellular matrix molecules, MMPs can modulate a variety of stem cell niches. Using mesenchymal stem cells derived from gingival (gum) and adipose (fat) tissue, the group is working to induce MSC to undergo osteogenesis so that they can be used as part of a novel therapeutic approach to craniofacial reconstruction.  The group is also studying ways to reactivate senescence stem cells isolated from older patients in order to provide patient specific stem cells in tissue regeneration. 

Click here for Sylvia's page in the Faculty of Medicine.

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