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The University of Southampton
Centre for Human Development, Stem Cells and RegenerationResearch themes

Clinical Bone Repair

Key examples of the clinical need for bone regeneration strategies are spinal non-union (A) and revision hip (B) and knee (C) replacement  surgery. The arrows indicate areas of significant bone loss.
Clinical need

Many clinical scenarios require the replacement of large volumes of lost bone. Bone graft substitutes have been developed using tissue engineering strategies to address these problems. Our research has focused on improving the biological and mechanical properties of existing bone graft strategies - using the principles of tissue engineering to promote bone formation. For example, by supplementing bone graft with stem cells enriched from the bone marrow, we have observed marked in bone repair in the clinic. In collaboration with orthopaedic surgeons in Southampton, we are making tentative steps towards translating these approaches into clinical practice to improve bone healing.

We applying tissue engineering principles to clinical bone grafting strategies to enhance bone formation, for example by supplementing graft with bone marrow cells (A and B) or applying trabecular met
Tissue engineering



Smith JO, Sengers BG, Aarvold A, Tayton ER, Dunlop DG, Oreffo RO.>Tantalum trabecular metal - addition of human skeletal cells to enhance bone implant interface strength and clinical application.J Tissue Eng Regen Med. 2012 Jun 4. doi: 10.1002/term.1525. [Epub ahead of print]PMID:22674820

Tayton ER, Smith JO, Aarvold A, Kalra S, Dunlop DG, Oreffo RO.Translational hurdles for tissue engineering: An in vitro analysis of commonly used local anaesthetics on skeletal stem cell survival.J Bone Joint Surg Br. 2012 Jun;94(6):848-55.PMID:22628604

Tayton E, Purcell M, Aarvold A, Smith JO, Kalra S, Briscoe A, Shakesheff K, Howdle SM, Dunlop DG, Oreffo RO.Supercritical CO2 fluid-foaming of polymers to increase porosity: a method to improve the mechanical and biocompatibility characteristics for use as a potential alternative to allografts in impaction bone grafting?Acta Biomater. 2012 May;8(5):1918-27. Epub 2012 Jan 24.PMID:22307029

Aarvold A, Smith JO, Tayton ER, Tilley S, Dawson JI, Lanham SA, Briscoe A, Dunlop DG, Oreffo RO.Taking tissue engineering principles into theatre: retrieval analysis from a clinically translated case.Regen Med. 2011 Jul;6(4):461-7.PMID:21749204

Skeletal tissue regeneration: current approaches, challenges, and novel reconstructive strategies for an aging population.Smith JO, Aarvold A, Tayton ER, Dunlop DG, Oreffo RO.Tissue Eng Part B Rev. 2011 Oct;17(5):307-20. Epub 2011 Jun 30. Review.

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