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Dr Matthew Carter

Senior Research Fellow

Research interests

  • Antibody Immunotherapy
  • Hypoxia
  • Molecular Cell Biology

More research

Accepting applications from PhD students.

Connect with Matthew

Email: M.J.Carter@soton.ac.uk

Profile photo 
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Name 
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Job title 
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Research interests (for researchers only) 
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In Pure (opens in a new tab), select ‘Edit profile’. Under the heading 'Curriculum and research description', select 'Add profile information'. In the dropdown menu, select 'Research interests: use separate lines'.

Contact details 
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ORCID ID 
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Accepting PhD applicants (for researchers only) 
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About Research Publications Supervision Teaching External roles and responsibilities Biography
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About

Dr. Carter earned a First-Class Honours degree in Biochemistry from the University of Southampton in 2008. He then pursued a PhD under the guidance of Professor Mark Cragg, focusing on the molecular regulation of apoptosis in B-cell malignancies. This research deepened his understanding of complex cell survival mechanisms, particularly the role of BH3-only members of the BCL-2 family.

Following his PhD, Dr. Carter continued his research as a postdoctoral fellow in the same lab, investigating the impact of isoform-selective PI3 kinase inhibitors on antibody therapeutics in B-cell cancers. These studies uncovered that the mechanism of action of PI3 kinase inhibitors was linked to increased cellular apoptosis, mediated by the BIM BH3-only protein. Accordingly, a novel combinational therapeutic strategy was devised, based on this new understanding, which reduced tumour burden by 96% in pre-clinical models. More recently, Dr. Carter has explored the mechanisms of action of innovative antibody immunotherapies and bromodomain inhibitors targeting the BET family.

You can update this in Pure (opens in a new tab). Select ‘Edit profile’. Under the heading and then ‘Curriculum and research description’, select ‘Add profile information’. In the dropdown menu, select - ‘About’.

Write about yourself in the third person. Aim for 100 to 150 words covering the main points about who you are and what you currently do. Clear, simple language is best. You can include specialist or technical terms.

You’ll be able to add details about your research, publications, career and academic history to other sections of your staff profile.

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