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The University of Southampton
Biological Sciences
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Dr Paul Skipp BSc, PhD

Associate Professor in Proteomics, Head of Proteomics, Centre for Proteomic Research

Dr Paul Skipp's photo

Dr Paul Skipp is an Associate Professor in Proteomics within Biological Sciences at the University of Southampton.

Career history

2016-present: Associate Professor. University of Southampton, UK.
2013-2016: Lecturer. University of Southampton, UK.
1990-2014:Experimental Officer. University of Southampton, UK.

Research interests


The term proteome defines the entire protein complement in a given cell, tissue or organism. In its wider sense, proteomics research also assesses protein activities, modifications and localization, and interactions of proteins in complexes. By studying global patterns of protein content and activity and how these change during development or in response to disease, proteomics research is poised to boost our understanding of systems-level cellular behaviour. Clinical research is also benefiting from proteomics by both the identification of new drug targets and the development of new diagnostic markers.

Our research at the Centre for Proteomic Research combines in-depth expertise with internationally competitive facilities for the large-scale characterization of proteins expressed in health and disease. This involves the application of a number of analytical proteomic technologies to a range of biological problems in a wide variety of organisms/tissues.

Research group

Plants and Food Security

Affiliate research groups

Neuroscience, Computational and Systems Biology, Developmental Biology, Molecular and Cellular Biosciences, Microbiology

Research project(s)

Mechanistic insight into the regulatory role of the key kinetochore protein Spc105/KNL1 in chromosome segregation

A large and mostly unstructured protein Spc105/KNL1 is an essential element of the eukaryotic kinetochore. The project addresses a question of how this protein performs its function as a binding platform for multiple regulatory components to control the proper chromosome segregation during mitosis.

Uncovering the molecular mechanisms of asymmetric cell divisions in the adult mammary epithelium

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Book Chapter

  • O'Connor, C. D., Clarke, I. N., & Skipp, P. (2006). Quest for complete proteome coverage. In I. Humphery-Smith, & M. Hecker (Eds.), Microbial Proteomics: Functional Biology of Whole Organisms (pp. 27-38). (Methods of Biochemical Analysis; Vol. 49). Hoboken, US: John Wiley & Sons. DOI: 10.1002/0471973165.ch3



Additional publications

Parkinson, E., Skipp, P.J., Aleksic, M., Scott, D.J., Clough, G and O'Connor, C.D. (2009) Quantitative Proteomic Analysis of SDS-induced Responses in Human Skin. Molecular and Cellular Proteomics (submitted)

Jones, B.M., Edwards, R.J, Skipp, P.J., O’Connor, C.D., Iglesias-Rodriguez, M.D., (2009) Shotgun proteomic analysis of Emiliania huxleyi, a marine phytoplankton species of major biogeochemical importance. Proteomics (submitted)

Mary I, Law A, Skipp P, Holland R, Topping J, Tarran G, Scanlan, DJ, O’Connor CD, Burkill PH and Zubkov MV (2009). Flow cytometric sorting of microwave fixed microbial cells for genomic and proteomic analyses. Limnology and Oceanography (submitted)

O'Connor, C.D., Clarke, I.N. and Skipp, P. (2006) Quest for complete proteome coverage. In: Microbial Proteomics: Functional Biology of Whole Organisms. Wiley, New York . Edited by I. Humphery-Smith and M. Hecker. pp. 27-38.

O'Connor, C.D., Clarke, I.N. and Skipp, P. (2006) Quest for complete proteome coverage. Methods Biochem Anal, 49, 27-38.

Skipp, P., Farooqui, M., Pickard, K., Li, Y., Evans, A.G.R. and O'Connor, C.D. (2004) . Expanding the information window to increase proteomic sensitivity and selectivity. In: Proceedings of NATO Advanced workshop on Proteomics and Toxicogenomics. Edited by J.J. Valdes and J.W. Sekowski. IOS Press, Amsterdam, The Netherlands , pp. 33-42.

Skipp, P., Farooqui, M., Evans, A. and O'Connor, C.D. (2002) Desorption/Ionisation on Silicon (DIOS): Highly reproducible, enhanced surfaces for proteomics. Molec. Cell. Proteomics 1, 690.

O'Connor, C.D., Adams, P., Alefounder, P., Farris, M., Kinsella, N., Li, Y., Payot , S., and Skipp, P. (2000) The analysis of microbial proteomes: strategies and data exploitation. Electrophoresis. 21, 1178 - 1186

University of Southampton

Centre Manager Centre for Proteomic Research

Dr Paul Skipp
School of Biological Sciences
Faculty of Environmental and Life Sciences
Life Sciences Building 85
University of Southampton
Highfield Campus
SO17 1BJ

Room Number: 85/5143

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