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The University of Southampton
Medicine
Email:
M.J.Carter@soton.ac.uk

Dr Matthew J Carter Senior Research Fellow

BSc, MRes, PhD

Dr Matthew J Carter's photo

Dr Matthew Carter is a senior research fellow within the Faculty of Medicine.

My research lies at the interface between cell biology and immunology. Via utilisation of small molecule signalling inhibitors, I aim to enhance the ability of the immune system to respond to immunotherapy approaches and deliver maximal therapeutic responses for patients.

Dr Carter completed an MRC-funded integrated PhD in cancer cell biology and immunology at the University of Southampton in 2012. Specifically, he studied the molecular regulation of apoptosis in B-cell neoplasms and utilised this knowledge to devise novel treatment strategies for cancer. He subsequently studied, and identified the mechanisms of, novel therapeutics for the treatment of B-cell leukaemia and lymphoma in collaboration with industrial partners (Gilead Sciences, Pfizer, Roche, Plexxikon). In combination with his doctoral studies, this work culminated in publications in prestigious journals including Blood, Leukemia, and Cell Death and Differentiation. Following these publications, Dr Carter was awarded the Catovsky prize from the UK CLL Forum (2015) in addition to the John Marsden prize (2016), and a Faculty of Medicine Career Track Fellowship (2015) both from the University of Southampton.

Dr Carter continues to work in the laboratory of Prof. Mark Cragg and focuses upon understanding the complex interplay between tumour cells and the immune system and how this impacts responses to therapy. Dr Carter’s research overlaps the disciplines of cell biology and immunology, combining complex genetic, epigenetic, and gene expression studies with cell biology and immunology approaches. He is focused upon understanding how small molecule signalling inhibitors may be applied to augment the immune system and maximise responses to novel and existing immunotherapy approaches.

Qualifications:

BSc (hons), Biochemistry (1st Class), University of Southampton (2008)

MRes, Cell Biology & Immunology of Cancer (2009)

PhD, University of Southampton (2012)

Appointments Held:

Research Fellow, Cancer Sciences Unit, University of Southampton (2012-2015)

Career Track Fellow, Cancer Sciences Unit, University of Southampton (2015-2017)

Research Fellow, Cancer Sciences Unit, University of Southampton (2017-2020)

Senior Research Fellow, Cancer Sciences Unit, University of Southampton (2020-present).

Research interests

My research focuses upon understanding the molecular mechanisms of novel and established therapeutics, with a particular focus upon apoptosis regulation. It is anticipated that this increased knowledge will inform best-use of these agents and maximise patient responses to therapy.

PhD Supervision

Dr Carter has recently completed supervision of doctoral studies for a clinical research fellow and has recruited a new PhD student, commencing autumn 2020.

Research group

Cancer Sciences

Faculty of Medicine Postdoctoral association committee member

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Articles

Book Chapter

Laboratory supervision of PhD and BSc students in the research group of Prof. Mark Cragg

Dr Matthew J Carter
Antibody & Vaccine Group,
Centre for Cancer Immunology,
Cancer Sciences Unit,
Southampton General Hospital (MP217),
Tremona Road,
Southampton,
SO16 6YD,
UK

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