The University of Southampton
Medicine
Phone:
(023) 8120 4989
Email:
s.faust@soton.ac.uk

Professor Saul Faust MA, MBBS, FRCPCH, PhD, FHEA

Professor of Paediatric Immunology and Infectious Diseases, Director, Southampton NIHR Wellcome Trust Clinical Research Facility

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Professor Saul Faust is Professor of Paediatric Immunology and Infectious Diseases within Medicine at the University of Southampton.

I combine a portfolio of active research into bridging the clinical and laboratory interface in paediatric and adult infectious diseases, immunology and respiratory medicine, together with early and late phase clinical trials; and a clinical research management and governance role as Director of the Southampton NIHR Wellcome Trust Clinical Research Facility

Saul N Faust is Professor of Paediatric Immunology & Infectious Diseases and Director of the Southampton NIHR Wellcome Trust Clinical Research Facility.

As an MRC Clinical Training Fellow in Paediatric Intensive Care & Infectious Diseases and then Clinical Lecturer at Imperial College London, he completed his PhD on the pathophysiology of coagulation abnormalities in meningococcal sepsis, work that led directly to clinical trials in paediatric intensive care. Current projects include work to bridge the clinical-laboratory interface in paediatric and adult infectious diseases, immunology and respiratory medicine (including biofilm-related clinical diseases), developing local and national collaborative clinical trials in paediatric infectious diseases, and conducting paediatric and adult vaccine trials as part of the UK academic paediatric vaccine group.

Professor Faust is currently Chair of the UK NIHR Medicines for Children Clinical Specialty Group Chairs' Forum and the Clinical Speciality Group for Allergy, Infectious Diseases and Immunity.  He is Wessex Clinical Research Network Specialty Lead for Paediatrics and co-Director of the South Central Children’s Research Network (SoCCR).

Qualifications


BA (MA) Social & Political Sciences, Cambridge University (1990 (1995))
MB BS, University of London (1993)

Membership of Royal College of Paediatrics & Child Health (1996)

Fellow of Higher Education Academy (previously Institute of Learning & Teaching in Higher Education) (2001)

PhD, Imperial College, London (2005)

Certificate of Advanced Study in Learning & Teaching, Imperial College, London (2006)

Certificate of Good Clinical Practice, Faculty of Pharmaceutical Medicine (2007)

Appointments held

Professor and Honorary Consultant of Paediatric Immunology and Infectious Diseases

Director, NIHR Wellcome Trust Clinical Research Facility, University of Southampton

Research

Responsibilities

Publications

Teaching

Contact

Research interests

Clinical biofilm research

Professor Faust is clinical lead for the University of Southampton Institute for Life Sciences Biofilm and Microbial Communities Research Group. Together with colleagues from the Faculty of Medicine (Stuart Clarke, Rami Salib), Faculty of Natural and Environmental Sciences (Jeremy Webb, Bill Keevil) and the National Centre for Advanced Tribology in the Faculty of Engineering (Paul Stoodley), the group have developed a range of methods based in the Southampton NIHR Wellcome Trust Clinical Research Facility (WTCRF) and University laboratories, including direct and confocal microscopy, live/dead stain and analysis, colony forming unit assessment, fluorescent in-situ hybridisation (FISH) and quantitative PCR, that together act as novel microbiological biomarkers to assess the response of ex-vivo biofilms before, during and after the use of novel treatments in clinical trials, and to better diagnose and understand biofilm-related diseases. As part of the Southampton National Institute for Health Research Respiratory Biomedical Research Unit we are currently investigating novel adjunctive therapies in cystic fibrosis, paediatric otitis media, adult CRS, catheter-related intravascular line infections and ventilator-associated pneumonias, as well as working on orthopaedic implant and wound infections.

Paediatric clinical trials

Professor Faust leads and participates in clinical trials aimed at understanding disease and improving the clinical management of paediatric infections and acts as Southampton principal investigator on a number of NIHR non-commercial and commercial portfolio clinical trials.

Paediatric and adult vaccine trials

Professor Faust has established the Southampton NIHR WTCRF as one of the main academic paediatric vaccine centres that form the UK Paediatric Vaccine Group. In collaboration with colleagues at Oxford, Bristol and St Georges London he shares the leadership, design, and delivery of multicentre vaccine trials and acts as Southampton PI for NIHR commercial portfolio paediatric and adult vaccine research. Professor Faust also collaborates with the Oxford Jenner Institute to enroll Southampton adults in early phase trials of novel influenza and malaria vaccines and with Professor Robert Read in Southampton to develop bacterial and viral challenge models and develop new vaccines.

With Stuart Clarke (Clinical and Experimental Sciences), Professor Faust leads the paediatric clinical component of longitudinal molecular epidemiological bacterial carriage studies to inform vaccine policy and design.

Paediatric Recurrent Infection and Immunodeficiency

Together with Tony Williams (Cancer Sciences), Professor Faust co-leads a programme of work investigating novel innate immune defects in children and families with recurrent infections but no defined immunodeficiency. The group have combined new investigative approaches that assess immune competency in innate immune pathways with participation in national and international collaborations. 

Clinical Research Management and Governance

As the Southampton NIHR WTCRF Director, Professor Faust ensures the CRF acts as the operational focus of the Southampton Centre for Biomedical Research, working with colleagues across the University and University Hospital Southampton Foundation Trust to ensure easy access to research facilities for all investigators and maximum efficiency and economy of scale across the translational research infrastructure.

Research group

Clinical and Experimental Sciences Academic Units

Affiliate research group

Infection and Immunity Research group

University of Southampton

Member of Engaged University Steering Group

Fitness to Practise Investigator

Member of child health undergraduate teaching committee

Regional responsibilities

Clinical lead for NIHR Clinical Research Network: Wessex; Division 3

National responsibilities

Chair, NIHR CRN Paediatric Theme Clinical Speciality Group Chairs' Forum

Chair, NIHR CRN Paediatric Theme Specialty Group for Allergy, Infection and Immunity (2011-)

Convenor, UK Paediatric Clinical Research Facilities Forum

British Paediatric Allergy, Immunology & Infectious Diseases Group Convenor

Articles

Review

Book Chapters

    Morris, O., Tebruegge, M., Pallett, A., Green, S., Pearson, A. D., Tuck, A., ... Faust, S. N. (2013). Clostridium difficile in children: a review of existing and recently uncovered evidence. In N. Curtis, A. Finn, & A. J. Pollard (Eds.), Hot Topics in Infection and Immunity in Children IX. (pp. 57-72). (Advances in Experimental Medicine and Biology; Vol. 764). New York, US: Springer. DOI: 10.1007/978-1-4614-4726-9_4
    Faust, S. N., Clark, J., & Clarke, N. (2011). Bone and joint infections. In M. Sharland, A. Cant, E. G. Davies, D. A. C. Elliman, S. Esposito, A. Finn, F. Gray, P. T. Heath, H. Lyall, A. J. Pollard, M. E. Ramsay, A. Riordan, ... D. Shingadia (Eds.), Manual of Childhood Infections. (pp. 38-43). Oxford, GB: Oxford University Press.
    Faust, S. N., Baguley, D. S., & Cathie, K. (2009). Aseptic meningitis. In Pediatric Textbook at eMedicine.com. eMedicine.
    Faust, S. N., Cathie, K., & Levin, M. (2009). Meningococcal infections. In Paediatric textbook at emedicine.com.
    Faust, S. N., & Nadel, S. (2009). Purpura fulminans. In J. Revez, J-C. Roujeau, F. A. Kerdal, & L. Valeyrie-Allanore (Eds.), Life-Threatening Dermatoses and Emergencies in Dermatology. (pp. 45-56). Heidelberg, DE: Springer.
    Faust, S. N., & Lyall, E. G. H. (2007). Infection. In T. Lissauer, & G. Clayden (Eds.), Illustrated Textbook of Paediatrics. (pp. 225-252). Edinburgh, UK: Mosby International.
    Levin, M., Eley, B. S., & Faust, S. (2005). Purpura fulminans. In J. Harper, A. Oranje, & N. S. Prose (Eds.), Textbook of Paediatric Dermatology. (pp. 1902-1916). Oxford, UK: Blackwell Science.
    Faust, S. N. ., Habibi, P., & Heyderman, R. S. (2005). Skin manifestations of meningococcal infection. In J. Harper, A. Oranje, & N. S. Prose (Eds.), Textbook of Paediatric Dermatology. (pp. 471-485). Oxford, UK: Blackwell Science.

Conferences

 

 

Professor Saul Faust
Faculty of Medicine, University of Southampton, University Hospital Southampton NHS Foundation Trust, Mailpoint 218, C level West Wing, Tremona Road, Southampton SO16 6YD. PA: Sue Jackson (WTCRF) tel 023 8120 6883 sj2@soton.ac.uk

Room Number:SGH/WC173/MP218

Telephone:(023) 8120 4989
Facsimile:(023) 8120 5023
Email:s.faust@soton.ac.uk

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