About
Ivo Tews uses crystallography to study molecular interactions. Particular intrests are in large dynamic macromolecular complexes and time resolved techniques. As a member of the CCP4 project for crystallographic software he chairs working group 2, and is engaged in Synchrotron Science at the Diamond Light Source and the EUropean Synchtrotron Radiation Facilty.
Research
Research groups
Research interests
- Natural products biosynthesis: a complex cascade of catalytic steps in vitamin B6 biosynthesis is characterised by structures or reaction intermediates in the large PLP syntase complexEdit
- Bacterial biofilms: understanding of RedOx regulated phosphodiesterase activity in dispersal of biofilms to address chronic infections
- Cancer immunology: together with Cancer Immunology at Southampton we use a structure based apporach in developing novel cancer therapie
Research projects
Active projects
Researchers:
Researchers:
Sponsor: Cancer Research UK
Completed projects
Researchers:
Researchers:
Sponsor: Science And Technology Facilities Council
Sponsor: Medical Research Council
Researchers:
Researchers:
Sponsor: Cancer Research UK
Researchers:
Sponsor: Wessex Medical Research
Publications
79 publications
Page 1 of 8
Hans E Pfalzgraf, Aditya G Rao, Kakali Sen, Hannah R Adams, Marcus Edwards, You Lu, Chin Yong, Sofia Jaho, Takehiko Tosha, Hiroshi Sugimoto, Sam Horrell, James Beilsten-Edmands, Robin L Owen, Colin R Andrew, Jonathan A R Worrall, Ivo Tews, Adrian J Mulholland, Michael A Hough & Thomas W Keal,
2025, Chemical Science, 16(35), 16266-16283
DOI: 10.1039/d5sc04213e
Type: article
Courtney J. Tremlett, Jack Stubbs, William S. Stuart, Patrick D. Shaw Stewart, Jonathan West, Allen M. Orville, Ivo Tews & Nicholas J. Harmer,
2025, IUCrJ, 12(3), 262-279
Type: article
Isabel G. Elliott, Hayden Fisher, H.T. Claude Chan, Tatyana Inzhelevskaya, C. Ian Mockridge, Christine A. Penfold, Patrick J. Duriez, Christian M. Orr, Julie Herniman, Kri T.J. Müller, Jonathan W. Essex, Mark S. Cragg & Ivo Tews,
2025, Nature Communications, 16(1)
Type: article
Charlotte Cordery, Jack Craddock, Martin Malý, Kieran Basavaraja, Jeremy S. Webb, Martin A. Walsh & Ivo Tews,
2024, RSC Chemical Biology, 5(10), 1052-1059
DOI: 10.1039/d4cb00113c
Type: article
Abigail S.L. Sudol, Max Crispin & Ivo Tews,
2024, The Journal of Biological Chemistry, 300(5)
Type: article
Rachel Bolton, Moritz M. Machelett, Jack Stubbs, Danny Axford, Nicolas Caramello, Lucrezia Catapano, Martin Malý, Matthew J. Rodrigues, Charlotte Cordery, Graham J. Tizzard, Fraser MacMillan, Sylvain Engilberge, David von Stetten, Takehiko Tosha, Hiroshi Sugimoto, Jonathan A.R. Worrall, Jeremy S. Webb, Mike Zubkov, Simon Coles, Eric Mathieu, Roberto A. Steiner, Garib Murshudov, Tobias E. Schrader, Allen M. Orville, Antoine Royant, Gwyndaf Evans, Michael A. Hough, Robin L. Owen & Ivo Tews,
2024, Proceedings of the National Academy of Sciences of the United States of America, 121(12), e2308478121
Type: article
Jack Stubbs, Theo Hornsey, Niall Hanrahan, Luis Blay Esteban, Rachel Bolton, Martin Malý, Shibom Basu, Julien Orlans, Daniele de Sanctis, Jung-uk Shim, Patrick D. Shaw Stewart, Allen M. Orville, Ivo Tews & Jonathan West,
2024, IUCrJ, 11
Type: article
Jon Agirre, Mihaela Atanasova, Haroldas Bagdonas, Charles B. Ballard, Arnaud Baslé, James Beilsten-Edmands, Rafael J. Borges, David G. Brown, J. Javier Burgos-Mármol, John M. Berrisford, Paul S. Bond, Iracema Caballero, Lucrezia Catapano, Grzegorz Chojnowski, Atlanta G. Cook, Kevin D. Cowtan, Tristan I. Croll, Judit Debreczeni, Nicholas E. Devenish, Eleanor J. Dodson, Tarik R. Drevon, Paul Emsley, Gwyndaf Evans, Phil R. Evans, Maria Fando, James Foadi, Luis Fuentes-Montero, Elspeth F. Garman, Markus Gerstel, Richard J. Gildea, Kaushik Hatti, Maarten L. Hekkelman, Philipp Heuser, Soon Wen Hoh, Michael A. Hough, Huw T. Jenkins, Elisabet Jiménez, Robbie P. Joosten, Ronan M. Keegan, Nicholas Keep, Eugene B. Krissinel, Petr Kolenko, Oleg Kovalevskiy, Victor S. Lamzin, David M. Lawson, Andrey A. Lebedev, Andrew G.W. Leslie, Martin Malý, Robert A. Nicholls & Ivo Tews,
2023, Acta crystallographica. Section D, Structural biology, 79(6), 449-461
Type: article
Alex Look, Daniel Burns, Ivo Tews, Ali Roghanian & Salah Mansour,
2023, Frontiers in Immunology, 14
Type: review
Biography
Prizes
- David Blow Prize (2011)
- PD, venia legendi (2011)
- David Blow Prize (2011)
- PD, venia legendi (2011)