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The University of Southampton
Medicine
Phone:
(023) 8120 6085
Email:
D.Boche@soton.ac.uk

Professor Delphine Boche PhD

Professor of Neuroimmunopathology

Professor Delphine Boche's photo
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Delphine Boche is a Professor of Neuroimmunopathology within Medicine at the University of Southampton. Her research focuses on understanding neuroinflammation and its consequences in patients affected by neurological disease.  She was the recipient of a European Marie Curie Individual Fellowship (2000) and of a MRC New Investigator Award (2006).

Microglia, the Dr Jekyll and Mr Hyde of the brain

Her main interest is to develop a greater understanding of the role of neuroinflammation in relation with ageing, neurological diseases and systemic inflammation, using the complementary approaches of human brain analysis and animal models. Her work is located at the junction between clinical neurodegenerative disease, human neuropathology and experimental neuroscience where she has developed expertise in neuroimmunopathology.

Delphine serves on: (i) International grant review boards for France, Canada, Spain and Belgium including The Weston Brain Institute, US Alzheimer’s Association, ERA-NET scheme of the European Commission, “La Caixa” Foundation; (ii) International editorial boards: Neuropathology and Applied Neurobiology, Scientific Reports; (iii) International conference committees: US Alzheimer’s Association co-chair of the Scientific Program, International Society to Advance Alzheimer's Research and Treatment (ISTAART); (iv) Grant review boards: Alzheimer’s Research UK, Hearing loss/ARUK, Wellcome Trust Cellular and Molecular Neuroscience Expert Review Group. Delphine sits on the BRAIN UK committee, Sheffield Brain bank committee, the Cambridge Brain Bank Committee and the British Neuropathological Society Academic committee. She was the external examiner for the MSc in Translational Neuropathology (Neuroscience) for Sheffield University (2015-2019).  In 2014, as the co-chair of the Southampton Neuroscience Group (SoNG) - a platform for collaborative, interdisciplinary and applied neuroscience- she initiated the Spring Event and Prizes for the best neuroscience project delivered by an undergraduate and a master’s students.  Since 2019, Delphine is chair of the PostDoctoral Association with the aim to enhance the development of the Early Career Researchers (ECRs) and represents the Faculty Concordat Champion, ensuring that the Principles of the Concordat with a particular focus on ECRs are implemented within the Faculty.

 

Qualifications

BSc Cell Biology and Physiology, University Paris 12, France (1991)
MSc Cell Biology, University Paris 12, France (1992)
MRes Neurosciences, College de France and University 6, France (1993)
PhD in Neurosciences, University Paris 6, France (1997)
Fellow of the Higher Education Academy, UK (2010)

Appointments held

Bourse Roux (Fellowship) Institut Pasteur Paris (France): 1998-1999
Marie Curie Fellow (European Community), School of Biological Sciences, University of Southampton (UK): 2000-2001
Post-Doctoral Research Fellow, School of Biological Sciences, University of Southampton (UK): 2001-2004
Post-Doctoral Research Fellow, School of Medicine, University of Southampton (UK): 2004-2006
MRC New Investigator, School of Medicine, University of Southampton (UK): 2006-2009
Lecturer, Faculty of Medicine, University of Southampton (UK): 2009-2013
Associate Professor, Faculty of Medicine, University of Southampton (UK): 2013-2017
Professor of Neuroimmunopathology, Faculty of Medicine, University of Southampton (UK): 2017-present

Research interests

Delphine serves as PI and Co-PI on a range of neuroscience research projects focusing on neuroinflammation and neurodegeneration.  Her research investigates the role of microglia, the immune cells of the brain, in neurodegenerative diseases using the complementary approaches of human brain tissue analysis and animal models. 

 

Immunophenotyping microglia in neurological conditions such as: Alzheimer’s disease, dementia with Lewy bodies, Frontotemporal dementia, schizophrenia, glioblastoma


Neuroinflammation in age-related dementia


Exploring the impact of systemic inflammation on the brain pathology and inflammation


Aβ immunotherapy in human Alzheimer’s disease

Department(s)

Clinical and Experimental Sciences

Affiliate Department(s)

Clinical Neuroscience Research group

International grant review boards

  • Agence Nationale de la Recherche (French governmental Agency for Scientific Research) – Member of the Scientific Committee section Neuroscience CES16 (2021 on)
  • Member of the Research Foundation – Flanders (FWO) Review College (2021-2023)
  • The Royal Society - Member of the Society’s Newton International Fellowships Committee: Biological Sciences (2021-2023)
  • “La Caixa” Foundation Health Research Selection Committee - Neuroscience High Level Expert panel (Spain, 2020)
  • “Network of European Funding for Neuroscience Research” (NEURON) under the ERA-NET scheme of the European Commission, Member of the Peer Review Panel for the "Transnational Research Projects on Mental Disorders" call (2018)
  • Canadian Weston Brain Institute, grant review panel (2015 on)
  • US Alzheimer’s Association, Canadian Weston Brain Institute and Alzheimer’s Research UK joint grant review panel for “Mechanisms of Cellular Death in Neurodegeneration” (MCDN) call (2015)

 

International editorial boards

  • Frontiers in Neuroscience – Neurodegeneration and Molecular Neuroscience, Review Editor (2018 on)
  • Scientific Reports (Neurology, Nature Publishing Group), Editorial Board (2015 on)
  • Neuropathology and Applied Neurobiology, Editorial Board (2015 on)
  • Brain Pathology, Senior Editor, special review issue on the “Inflammasome” (2017)
  • Neuropathology and Applied Neurobiology, Guest Editor, special review issue on “Neuroinflammation in ageing and neurodegenerative disease” (2013)

 

International conference committees

  • US Alzheimer’s Association, Co-chair of the Scientific Program Committee, International Conference (2019 on)
  • US Alzheimer’s Association, Lead for the “Basic and Translational Science” Theme, Scientific Program Committee, International Conference (2017-2019)
  • US Alzheimer's Association, International Society to Advance Alzheimer's Research and Treatment (ISTAART), Executive Committee member of the Professional Interest Area “Immunity and Neurodegeneration” (2015 on)
  • The Alzheimer’s Disease Congress, Advisory Board (2014-2015)

 

International (other activities)

  • European Alzheimer’s Disease Consortium, Southampton lead (2013-2018)
  • International Conference on Alzheimer’s Disease (ICAD), selected for media/press presentation (2010)
  • Nominated expert for: US Alzheimer’s Association; France Alzheimer; “Agence Nationale de la Recherche”; Israel Science Foundation; Research Foundation Flanders (FWO), Hong Kong Council, L’Oreal-UNESCO, National University of Singapore.

 

National grant review boards

  • Wellcome Trust Cellular and Molecular Neuroscience Expert Review Group (2020)
  • Action of Hearing Loss - Alzheimer’s Research UK, Grant Review Board (2018 on)
  • Medical Research Council, Grant Review Board for the “Human Cell Atlas” Initiative (2018)
  • Alzheimer’s Research UK, Grant Review Board (2016 on)
  • Alzheimer’s Society, UK, PhD review panel (2015-2018)

 

National Examining

  • External Examiner, MSc in Translational Neuropathology (Neuroscience), Faculty of Medicine, Dentistry and Health, University of Sheffield (2015-2019)

 

National administration

  • BRAIN UK User Representative on the Committee (2019 on)
  • British Neuropathological Society Academic Committee (2018 on)
  • Sheffield Brain bank, Committee member (2018 on)
  • UK Brains for Dementia Research, Steering Committee member (2014-2018)
  • The Cambridge Brain Bank, University of Cambridge, Committee member (2014 on)
  • Alzheimer’s Research UK National Network, South Coast Regional Chair (2008-2014), included hosting the national conference in Southampton (2010)

 

Local

  • University of Southampton, Faculty of Medicine, Chair of the PostDoctoral Association Steering Committee (2019 on)
  • University of Southampton, Faculty of Medicine, Concordat Champion (2019 on)
  • University of Southampton, Southampton Neurosciences Group (SoNG), co-chair, (2013-2016)

 

National examining

  • External Examiner, MSc in Translational Pathology (Neuroscience), Faculty of Medicine, Dentistry and Health, University of Sheffield (2015-2019)

 

Supervision

35 BMEdSc

21 MMEdSc / MSc

7 PhD

7 Academic Clinical Fellows completed

11 International visitors

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Articles

Book Chapters

Conferences

Reviews

BM5. Lectures on the Locomotor & Nervous Systems Courses

BM4. Facilitator

BIOL3037/BIOL6038 Immunology. Lectures on Neuroimmunology

BMedSc/MMedSc. project supervisor

BIOL6084. Workpackage on Human Neuropathology and Brain Banks

BIOL6092. MSc Neuroscience Research Project

Personal Academic Tutor for students

Professor Delphine Boche
Faculty of Medicine Clinical and Experimental Sciences University of Southampton Southampton General Hospital Mailpoint 806 Southampton SO16 6YD

Room Number: SGH/LD62/MP806

Telephone:(023) 8120 6085
Email:D.Boche@soton.ac.uk

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