The University of Southampton
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BIOL1014 Integrative Mammalian Physiology

Module Overview

This module gives an introduction to the principles underlying cell communication in animal systems. It shows how the integration of various physiological systems occurs and how these communication and signalling methods maybe modified pharmacologically.

Aims and Objectives

Module Aims

The aim of this module is to introduce the principles and some of the mechanisms cell communication in animal systems. Endocrine, paracrine and cell-matrix interactions are described. It will then study how these maybe integrated into whole animal physiology for instance in functioning of the reproductive and immune systems. Finally these mechanisms will the viewed in a pharmacological setting. The lecture programme is supported by a series of 4 tutorials.

Learning Outcomes

Learning Outcomes

Having successfully completed this module you will be able to:

  • explain why cells need to communicate and to give examples of some of the processes involved in animals.
  • to understand the principles of immune recognition
  • to describe fertilisation and reproduction
  • to understand the principals of the mechanisms of action of drugs on tissues and some ways in which their effects might be tested in vitro and in vivo
  • to define the terms agonist and antagonist, competitive and non-competitive and partial agonist and antagonist
  • define and distinguish the roles of membrane bound, secreted and diffusible signalling molecules and relate this to their functions,
  • to describe the major components of the extracellular matrix and how cells adhere to it
  • to describe forms of cell-cell contact such as cadherin junctions and gap junctions and to appreciate the functions which these serve
  • describe the regulation systems of the major endocrine systems
  • describe the main endocrine systems axis between the hypothalamus and pituitary
  • understand the roles of the adrenal medulla and cortex, ,
  • explain the importance of , and mechanisms underlying the control of blood glucose insulin
  • understand the response of the mammalian body to acute and chronic stress

Syllabus

• Physiological Principles and Cellular Physiology • Cell and Tissue communication • Neurophysiology/Electrophysiology - Nerve, Muscle, Synapse • Endocrine function • Introduction to Immune System • Reproductive physiology

Learning and Teaching

Teaching and learning methods

The module will be taught via lectures, tutorials and self-assessment. Feedback is provided through coursework returns, tutorial session and asking staff for advice.

TypeHours
Lecture24
Tutorial4
Independent Study122
Total study time150

Assessment

Assessment Strategy

Examination: 2-hour paper requiring three questions to be answered. Two essays (from a choice of four) and a true/false paper containing approximately 50 sub-questions Continuous assessment derived from marks derived from work set through the module

Summative

MethodPercentage contribution
Coursework 25%
Written exam  (2 hours) 75%

Referral

MethodPercentage contribution
Coursework 25%
Written exam  (2 hours) 75%
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