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The University of Southampton

HPRS2022 Pathophysiology of Common Cardiovascular and Respiratory and Sleep

Module Overview

This module is designed to ensure that students know the pathophysiology of common Cardiovascular and Respiratory and Sleep conditions that are likely to result in referral for investigation to a Cardiovascular, Respiratory or Sleep service where, as accredited physiologists they will be expected to perform diagnostic procedures.

Aims and Objectives

Learning Outcomes

Knowledge and Understanding

Having successfully completed this module, you will be able to demonstrate knowledge and understanding of:

  • Recall the normal structure and function of the cardiac, vascular, and respiratory systems and blood cell types.
  • Become informed recipients of research evidence in healthcare science by critically appraising professional journals and associated literature using established appraisal tools.
  • Understand how major abnormalities of physiological control of the cardiac, vascular and respiratory systems result in disease and occur during the ageing process.
  • Identify basic mechanisms responsible for diseases of the cardiac, vascular and respiratory systems concentrating on disorders of cellular proliferation and death, responses to injury including inflammation, neoplasia, normal and abnormal immune responses, atheroma, thrombosis, embolism and infarction.
  • Recognise infection as the basis of disease in the respiratory tract, heart and vasculature.
  • Understand how genetics is involved in the pathophysiology of common cardiovascular and respiratory diseases.
  • Appreciate the underlying causes and socioeconomic implications of sleep disorders.
  • The impact of psychology on causes of and survival with common cardiovascular and respiratory diseases.
  • Recognise recent advances in diagnostic and prognostic technology in the relevant fields.
  • Gain an awareness of primary and secondary autonomic disorders.
Subject Specific Intellectual and Research Skills

Having successfully completed this module you will be able to:

  • Establish a vocabulary of terminology used in the classification, investigation and description of disease.
  • Integrate information from different laboratory disciplines.


Indicative Content Cellular, tissue and systems response to common Cardiac, Vascular and Respiratory diseases including: • Tissue response to injury • Cell death • Inflammation • Neoplasia • Normal and abnormal immune responses • Atheroma • Thrombosis • Embolism • Infarction • Anatomical airway obstruction • Genetic Mutations • The effect of the ageing process Basis of common infections affecting the Cardiac, Vascular and Respiratory Systems Common diseases of the Cardiac, Vascular and Respiratory system including the epidemiology, public health and psychosocial aspects including: Cardiac Disease • Ischaemic heart disease and myocardial infarction • Acquired valvular disease • Hypertensive heart disease • Cardiomyopathy • Congenital heart disease • Autonomic disorders Vascular Disease • Peripheral Arterial Disease • Venous Disease • Cerebrovascular disease Respiratory Diseases • Chronic Obstructive Pulmonary Disease • Asthma • Restrictive Lung Disease • Congenital Lung Conditions • Pneumonia • Lung Cancer • Cystic Fibrosis • Obstructive sleep apnoea • Central sleep apnoea This module will also consider the impact of smoking on health and introduce the common risk factors for cardiovascular disease and the concept of risk assessment.

Learning and Teaching

Teaching and learning methods

Students will learn by exploring material in lectures and laboratory practicals, in conjunction with directed learning. Students will be encouraged to manage their time and the development of their learning by utilising multimedia resources, and the library, and by self-directed development of the study skills necessary to access these resources.

Completion of assessment task3
Wider reading or practice50
Practical classes and workshops3
Preparation for scheduled sessions75
Total study time187

Resources & Reading list

Barbara J. Cohen, Jason J. Taylor, Ruth Lundeen Memmler (2005). Memmler's the structure and function of the human body. 

Author: Emanuel Rubin, Editor: Emanuel Rubin (2001). Essential pathology. 

Authors: P. John Rees, Daniel Gwyn Williams, Editors: P. John Rees, Daniel Gwyn Williams (1995). Principles of clinical medicine. 

Authors: Vinay Kumar, Stanley Leonard Robbins, Editors: Vinay Kumar, Stanley Leonard Robbins. Contributor: Stanley Leonard Robbins (2007). Robbins basic pathology. 

Gerard J. Tortora, Bryan Derrickson (2009). Principles of anatomy and physiology: maintenance and continuity of the human body, Volume 2. 

Gerard J. Tortora, Bryan Derrickson (2009). Principles of anatomy and physiology: Maintenance and continuity of the human body, Volume 1. 

Author: Carl Clare, Janet G. Migliozzi, Muralitharan Nair, Ian Peate, Peter S. Vickers, Anthony Wheeldon Editors: Muralitharan Nair and Ian Peate (2009). Fundamentals of applied pathophysiology: An essential guide for nursing students. 

Author: Parveen June Kumar, Michael L. Clark, Editor: Parveen June Kumar (2009). Kumar and Clark clinical medicine. 

Kathryn L. McCance, Sue E. Huether (2010). Pathophysiology: the biologic basis for disease in adults and children. 

Barbara Janson Cohen, Jason J. Taylor, Ruth Lundeen Memmler (2008). Memmler's the human body in health and disease. 

Rhoades, Rodney A. Bell, David R. Rodney A. Rhoades, David R. Bell. Medical physiology: Principles for clinical medicine. 



MethodPercentage contribution
Essay  (3000 words) 100%


MethodPercentage contribution
Essay 100%

Repeat Information

Repeat type: External

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