The University of Southampton

MEDI6079 Eczema, Urticaria and Anaphylaxis

Module Overview

Eczema, Urticaria and Anaphylaxis covers the aetiology and pathogenesis of allergic skin disease. In addition teaches the principles of systemic allergic reactions including anaphylaxis and its causes, a serious life threatening condition. This module will enable students to clinically recognise, investigate and manage these conditions.

Aims and Objectives

Module Aims

• To understand the aetiology and pathogenesis of allergic skin disease including an understanding of normal skin structure and function and how this is altered disease • To understand the principles and causes of systemic anaphylaxis • To understand the principles of diagnosis, investigation and management of these conditions

Learning Outcomes

Knowledge and Understanding

Having successfully completed this module, you will be able to demonstrate knowledge and understanding of:

  • Differentiate between the different forms of hypersensitivity reactions (I to IV) and highlight these with specific examples.
  • Evaluate the pathogenesis, diagnosis, investigation and management of systemic allergy.
  • Discuss normal skin structure and function and contrast this with changes seen in disease, particularly with reference to urticaria, contact dermatitis and atopic eczema.
Transferable and Generic Skills

Having successfully completed this module you will be able to:

  • Solve complex clinical and scientific issues both systematically and creatively.
  • Make informed judgements in a clinical and/or scientific setting and communicate these effectively to other professionals, parents and patients.
Cognitive Skills

Having successfully completed this module you will be able to:

  • Interpret diagnostic information from clinical scenarios.
  • Determine the differential diagnoses of allergic diseases such as eczema, urticaria and anaphylaxis.


• Structure and function of skin • Type I mechanisms and pseudo Type I • Overview of Type I allergy including food, pollen, vespid drug and latex • How to recognise anaphylaxis • Investigations and management of anaphylaxis • Type II and III hypersensitivity mechanisms, overview, investigations and management • Type IV mechanisms of allergic disease • Overview of Type IV allergy • How to recognise systemic IV reactions e.g. drugs • How to recognise cutaneous Type IV reactions e.g. allergic contact dermatitis, latex • Investigation and management of cutaneous and systemic allergy • Allergic skin disease differential diagnosis • Chronic urticaria and angioedema • Urticarial variants e.g. physical • Mastocytosis • Atopic dermatitis • Clinical cases for problem solving • Anaesthetic anaphylaxis • Latex allergy • Eczema • Drug rashes and relationship to allergic mechanisms • Anaphylaxis • Drug induced angioedema e.g. ACE inhibitors • Acute urticaria • Allergic contact dermatitis

Special Features

The module will be taught by a faculty at the forefront of their respective academic disciplines and professions of national and internationally recognised standing. Adult learning methods will be used throughout and an emphasis placed upon interactive learning, practical demonstration and the interpretation of clinical scenarios to reinforce learning

Learning and Teaching

Teaching and learning methods

A variety of learning and teaching methods will be adopted to promote a wide range of skills and meet the differing learning styles of the group. The techniques will include seminars, group work, practical demonstrations and exercises surrounding interpretation of data and clinical scenarios. Specialist lecturers from a range of academic and health care professional backgrounds will be used to ensure a breadth and depth of perspective is offered, giving a good balance between background theories and principles and practical management advice.

Independent Study220
Total study time250

Resources & Reading list

Ardern-Jones, M.R., and P.S.F. Friedmann. (2008). Eczema. In Managing Allergy. A. Custovic, and T.A.E. Platts-Mills, editors.. 

Friedmann, P.S.F., M.R. Ardern-Jones, and C.A. Holden (2010). Atopic Dermatitis. In Rook’s Textbook of Dermatology T. Burns, S. Breathnach, N. Cox, and C.E.M. Griffiths, editors. 

Holgate S, Church, M and Lichtenstein L (Eds) (2007). Allergy. Chapters 6-7 and 9-12. 

Global Atlas of Allergy. EAACI have produced an online Global Atlas of Allergy. To access the atlas, visit

EAACI Food Allergy and Anaphylaxis Guidelines. EAACI have produced these useful guidelines which are free for members. To access, visit

Useful journals.  Allergy Clinical Experimental Allergy Journal of Allergy and Clinical Immunology


Assessment Strategy

The assessment for the module provides you with the opportunity to demonstrate achievement of the learning outcomes. There will be two assessed components, i) a Professional skills analysis and ii) a Written assignment.


MethodPercentage contribution
Professional Skills Analysis  (1500 words) 50%
Written assignment  (2500 words) 50%


MethodPercentage contribution
Written assignment  (2500 words) 100%

Repeat Information

Repeat type: Internal & External


Costs associated with this module

Students are responsible for meeting the cost of essential textbooks, and of producing such essays, assignments, laboratory reports and dissertations as are required to fulfil the academic requirements for each programme of study.

In addition to this, students registered for this module typically also have to pay for:


Computer: It is advisable that students provide their own laptop or personal computer, although shared facilities are available across the University campus.

Please also ensure you read the section on additional costs in the University’s Fees, Charges and Expenses Regulations in the University Calendar available at

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