The University of Southampton
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BIOL1022 Metabolism and Metabolic Disorders

Module Overview

This module provides you with an understanding of: (1) the basic metabolic pathways; (2) inborn errors of metabolism and the application of DNA technology to their study; (3) the control and integration of metabolism. This module completes the first year teaching in biochemistry, following on from the first semester module on the Macromolecules of life (BIOL 1010/1007), looking at the much smaller metabolite molecules. These modules are prerequisites for most second year biochemistry and molecular biology modules

Aims and Objectives

Module Aims

The aims of the module are to provide you with an understanding of: (1) the basic metabolic pathways; (2) inborn errors of metabolism and the application of DNA technology to their study; (3) the control and integration of metabolism.

Learning Outcomes

Learning Outcomes

Having successfully completed this module you will be able to:

  • describe the principles of metabolism and the differences between anabolism and catabolism;
  • demonstrate an ability to handle simple mathematical treatments of biological processes.
  • Having done this course, together with the course on the Macromolecules of life (BIOL1007), you should be well-prepared for future work on more complex aspects of biochemistry and molecular biology, and molecular approaches to physiology, pharmacology, cell biology and biotechnology.
  • discuss the role of coenzymes, such as NAD+, FAD and ATP, in metabolism;
  • outline the metabolic pathways involving glucose, fatty acids and amino acids;
  • show how the energy released by catabolism is recouped by substrate level and oxidative phosphorylation;
  • describe the various types of genetic mutation and inborn errors of metabolism
  • describe the methods for detecting and correcting inborn errors of metabolism
  • outline the hormonal regulation of metabolism and discuss the role of protein phosphorylation in this context;
  • describe the regulation of metabolism in physiological and pathological situations (e.g. exercise, starvation and diabetes);
  • demonstrate that you have acquired skills in data interpretation and report writing

Syllabus

This module describes the major metabolic pathways that convert macromolecules consumed in the diet into smaller molecules and ultimately energy, including how these pathways are regulated. The causes and consequences of inborn mutations in key steps in these metabolic pathways are discussed, including options for treatment with DNA technology. Having covered the core metabolic pathways, the module ends with the mechanisms by which metabolism can be altered by altered physiological and pathological scenarios such as starvation, exercise and diabetes.

Special Features

N/A.

Learning and Teaching

Teaching and learning methods

Lectures, online practicals and individual study.

TypeHours
Independent Study128
Lecture22
Total study time150

Resources & Reading list

Papachristodoulou, Snape, Elliott & Elliott. Biochemistry & Molecular Biology 6th edition. 

Berg, Tymocsko and Stryer . Biochemistry. 

Meisenberg and Simmons. Principles of Medical Biochemistry. 

Mathews, Van Holde, Appling and Anthony-Cahill. Biochemistry. 

Voet and Voet. Biochemistry . 

Assessment

Summative

MethodPercentage contribution
Computer practicals 25%
Examination 75%

Referral

MethodPercentage contribution
Coursework 25%
Exam 75%

Linked modules

Pre-requisite: BIOL1010 Macromolecules of Life 2016-17.

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