Pathophysiology of Common Cardiovascular and Respiratory and Sleep

Learning Outcomes

Knowledge and Understanding

Having successfully completed this module, you will be able to demonstrate knowledge and understanding of:

• Recognise recent advances in diagnostic and prognostic technology in the relevant fields.
• Gain an awareness of primary and secondary autonomic disorders.
• Recognise infection as the basis of disease in the respiratory tract, heart and vasculature.
• Recall the normal structure and function of the cardiac, vascular, and respiratory systems and blood cell types.
• Appreciate the underlying causes and socioeconomic implications of sleep disorders.
• The impact of psychology on causes of and survival with common cardiovascular and respiratory diseases.
• Understand how genetics is involved in the pathophysiology of common cardiovascular and respiratory diseases.
• Identify basic mechanisms responsible for diseases of the cardiac, vascular and respiratory systems concentrating on disorders of cellular proliferation and death, responses to injury including inflammation, neoplasia, normal and abnormal immune responses, atheroma, thrombosis, embolism and infarction.
• Become informed recipients of research evidence in healthcare science by critically appraising professional journals and associated literature using established appraisal tools.
• Understand how major abnormalities of physiological control of the cardiac, vascular and respiratory systems result in disease and occur during the ageing process.

Subject Specific Intellectual and Research Skills

Having successfully completed this module you will be able to:

• Integrate information from different laboratory disciplines.
• Establish a vocabulary of terminology used in the classification, investigation and description of disease.

Indicative Content

Cellular, tissue and systems response to common Cardiac, Vascular and

Respiratory diseases including:

• Tissue response to injury
• Cell death
• Inflammation
• Neoplasia
• Normal and abnormal immune responses
• Atheroma
• Thrombosis
• Embolism
• Infarction
• Anatomical airway obstruction
• Genetic Mutations
• The effect of the ageing process

Basis of common infections affecting the Cardiac, Vascular and Respiratory

Systems

Common diseases of the Cardiac, Vascular and Respiratory system including the epidemiology, public health and psychosocial aspects including:

Cardiac Disease

• Ischaemic heart disease and myocardial infarction
• Acquired valvular disease
• Hypertensive heart disease
• Cardiomyopathy
• Congenital heart disease
• Autonomic disorders

Vascular Disease

• Peripheral Arterial Disease
• Venous Disease
• Cerebrovascular disease

Respiratory Diseases

• Chronic Obstructive Pulmonary Disease
• Asthma
• Restrictive Lung Disease
• Congenital Lung Conditions
• Pneumonia
• Lung Cancer
• Cystic Fibrosis
• Obstructive sleep apnoea
• Central sleep apnoea

This module will also consider the impact of smoking on health and introduce the common risk factors for cardiovascular disease and the concept of risk assessment.

Teaching and learning methods

Students will learn by exploring material in lectures and laboratory practicals, in conjunction with directed learning. Students will be encouraged to manage their time and the development of their learning by utilising multimedia resources, and the library, and by self-directed development of the study skills necessary to access these resources.

Resources & Reading list

Textbooks

Authors: Vinay Kumar, Stanley Leonard Robbins, Editors: Vinay Kumar, Stanley Leonard Robbins. Contributor: Stanley Leonard Robbins (2007). Robbins basic pathology. Saunders/Elsevier.

Barbara J. Cohen, Jason J. Taylor, Ruth Lundeen Memmler (2005). Memmler's the structure and function of the human body. Lippincott Williams & Wilkins.

Gerard J. Tortora, Bryan Derrickson (2009). Principles of anatomy and physiology: Maintenance and continuity of the human body, Volume 1. John Wiley & Sons.

Author: Carl Clare, Janet G. Migliozzi, Muralitharan Nair, Ian Peate, Peter S. Vickers, Anthony Wheeldon Editors: Muralitharan Nair and Ian Peate (2009). Fundamentals of applied pathophysiology: An essential guide for nursing students. John Wiley and Sons Ltd.

Authors: P. John Rees, Daniel Gwyn Williams, Editors: P. John Rees, Daniel Gwyn Williams (1995). Principles of clinical medicine. Edward Arnold.

Author: Parveen June Kumar, Michael L. Clark, Editor: Parveen June Kumar (2009). Kumar and Clark clinical medicine. Saunders Elsevier.

Kathryn L. McCance, Sue E. Huether (2010). Pathophysiology: the biologic basis for disease in adults and children. Mosby Elsevier.

Rhoades, Rodney A. Bell, David R. Rodney A. Rhoades, David R. Bell. Medical physiology: Principles for clinical medicine. Lippincott Williams and Wilkins.

Barbara Janson Cohen, Jason J. Taylor, Ruth Lundeen Memmler (2008). Memmler's the human body in health and disease. Lippincott Williams & Wilkins.

Gerard J. Tortora, Bryan Derrickson (2009). Principles of anatomy and physiology: maintenance and continuity of the human body, Volume 2. John Wiley & Sons.

Author: Emanuel Rubin, Editor: Emanuel Rubin (2001). Essential pathology. Lippincott Williams & Wilkins.

Summative

This is how we’ll formally assess what you have learned in this module.

Referral

This is how we’ll assess you if you don’t meet the criteria to pass this module.

Repeat Information

Repeat type: External